Detailed information NTG0608946

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: LCR03_RS08680
• Genome accession: NZ_CP084008
• Coordinates: 1867155..1868201 (-)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain NBRC 113846
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1862155..1873201

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LCR03_RS08650 (LCR03_08650)	-	1862539..1863780 (-)	1242	WP_002457094.1	aminopeptidase	-
LCR03_RS08655 (LCR03_08655)	-	1863782..1863997 (-)	216	WP_001830421.1	DUF1128 domain-containing protein	-
LCR03_RS08660 (LCR03_08660)	-	1864138..1864602 (+)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
LCR03_RS08665 (LCR03_08665)	-	1864610..1864894 (+)	285	WP_001830401.1	YtxH domain-containing protein	-
LCR03_RS08670 (LCR03_08670)	-	1865301..1866479 (+)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
LCR03_RS08675 (LCR03_08675)	vraR	1866536..1867165 (-)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
LCR03_RS08680 (LCR03_08680)	vraS	1867155..1868201 (-)	1047	WP_001830374.1	sensor histidine kinase	Regulator
LCR03_RS08685 (LCR03_08685)	liaF	1868198..1868899 (-)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
LCR03_RS08690 (LCR03_08690)	-	1868914..1869300 (-)	387	WP_001830382.1	hypothetical protein	-
LCR03_RS08695 (LCR03_08695)	map	1869458..1870213 (-)	756	WP_001830397.1	type I methionyl aminopeptidase	-
LCR03_RS08700 (LCR03_08700)	-	1870387..1871373 (+)	987	WP_020368335.1	aromatic acid exporter family protein	-
LCR03_RS08705 (LCR03_08705)	isaB	1871524..1872060 (-)	537	WP_001830372.1	immunodominant staphylococcal antigen IsaB family protein	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=608946 LCR03_RS08680 WP_001830374.1 1867155..1868201(-) (vraS) [Staphylococcus epidermidis strain NBRC 113846]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=608946 LCR03_RS08680 WP_001830374.1 1867155..1868201(-) (vraS) [Staphylococcus epidermidis strain NBRC 113846]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GATTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92