Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD46_RS08930 Genome accession   NZ_CP100936
Coordinates   1812121..1812777 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain ET650     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1807121..1817777
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD46_RS08895 (NMD46_08855) dcyD 1808000..1808986 (+) 987 WP_001128215.1 D-cysteine desulfhydrase -
  NMD46_RS08900 (NMD46_08860) tcyL 1809001..1809669 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  NMD46_RS08905 (NMD46_08865) tcyN 1809666..1810418 (+) 753 WP_001272994.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NMD46_RS08910 (NMD46_08870) sdiA 1810648..1811370 (+) 723 WP_001154273.1 transcriptional regulator SdiA -
  NMD46_RS08915 (NMD46_08875) yecF 1811438..1811662 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  NMD46_RS08920 (NMD46_08880) yecU 1811649..1811825 (-) 177 WP_000590344.1 protein YecU -
  NMD46_RS08925 - 1811863..1811979 (-) 117 WP_001302039.1 hypothetical protein -
  NMD46_RS08930 (NMD46_08885) letA 1812121..1812777 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NMD46_RS08935 (NMD46_08890) uvrC 1812774..1814606 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  NMD46_RS08940 (NMD46_08895) pgsA 1814663..1815211 (+) 549 WP_032278420.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NMD46_RS08960 (NMD46_08915) - 1815910..1816646 (-) 737 Protein_1744 hypothetical protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=607288 NMD46_RS08930 WP_000611328.1 1812121..1812777(+) (letA) [Escherichia coli strain ET650]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=607288 NMD46_RS08930 WP_000611328.1 1812121..1812777(+) (letA) [Escherichia coli strain ET650]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482