Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD49_RS10095 Genome accession   NZ_CP100927
Coordinates   2025344..2026000 (+) Length   218 a.a.
NCBI ID   WP_000611335.1    Uniprot ID   Q3Z2T8
Organism   Escherichia coli strain ET729     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2020344..2031000
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD49_RS10060 (NMD49_10005) dcyD 2021223..2022209 (+) 987 WP_085440702.1 D-cysteine desulfhydrase -
  NMD49_RS10065 (NMD49_10010) tcyL 2022224..2022892 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  NMD49_RS10070 (NMD49_10015) tcyN 2022889..2023641 (+) 753 WP_001272991.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NMD49_RS10075 (NMD49_10020) sdiA 2023871..2024593 (+) 723 WP_001152713.1 transcriptional regulator SdiA -
  NMD49_RS10080 (NMD49_10025) yecF 2024661..2024885 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  NMD49_RS10085 (NMD49_10030) yecU 2024872..2025048 (-) 177 WP_000590344.1 protein YecU -
  NMD49_RS10090 - 2025086..2025202 (-) 117 Protein_1973 transcriptional regulator -
  NMD49_RS10095 (NMD49_10035) letA 2025344..2026000 (+) 657 WP_000611335.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NMD49_RS10100 (NMD49_10040) uvrC 2025997..2027829 (+) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  NMD49_RS10105 (NMD49_10045) pgsA 2027886..2028434 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NMD49_RS10125 (NMD49_10065) - 2029128..2029867 (-) 740 Protein_1977 hypothetical protein -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23892.65 Da        Isoelectric Point: 6.9614

>NTDB_id=607044 NMD49_RS10095 WP_000611335.1 2025344..2026000(+) (letA) [Escherichia coli strain ET729]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRTNAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=607044 NMD49_RS10095 WP_000611335.1 2025344..2026000(+) (letA) [Escherichia coli strain ET729]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGCCGGACAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-115)

Bacterial regulatory proteins, luxR family (GerE)

(149-204)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q3Z2T8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

51.208

94.954

0.486
  letA Legionella pneumophila strain ERS1305867

51.208

94.954

0.486