Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   NMD58_RS09460 Genome accession   NZ_CP100890
Coordinates   1947216..1947872 (+) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain ET881     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1942216..1952872
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NMD58_RS09425 (NMD58_09370) dcyD 1943096..1944082 (+) 987 WP_032291442.1 D-cysteine desulfhydrase -
  NMD58_RS09430 (NMD58_09375) tcyL 1944097..1944765 (+) 669 WP_001158220.1 cystine ABC transporter permease -
  NMD58_RS09435 (NMD58_09380) tcyN 1944762..1945514 (+) 753 WP_001272991.1 L-cystine ABC transporter ATP-binding protein TcyN -
  NMD58_RS09440 (NMD58_09385) sdiA 1945744..1946466 (+) 723 WP_032291441.1 transcriptional regulator SdiA -
  NMD58_RS09445 (NMD58_09390) yecF 1946533..1946757 (-) 225 WP_000106474.1 DUF2594 family protein YecF -
  NMD58_RS09450 (NMD58_09395) yecU 1946744..1946920 (-) 177 WP_000590344.1 protein YecU -
  NMD58_RS09455 - 1946958..1947074 (-) 117 WP_001302039.1 hypothetical protein -
  NMD58_RS09460 (NMD58_09400) letA 1947216..1947872 (+) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  NMD58_RS09465 (NMD58_09405) uvrC 1947869..1949701 (+) 1833 WP_001283424.1 excinuclease ABC subunit UvrC Machinery gene
  NMD58_RS09470 (NMD58_09410) pgsA 1949758..1950306 (+) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  NMD58_RS09490 (NMD58_09430) yecA 1950955..1951620 (+) 666 WP_000847902.1 UPF0149 family protein YecA -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=606386 NMD58_RS09460 WP_000611328.1 1947216..1947872(+) (letA) [Escherichia coli strain ET881]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=606386 NMD58_RS09460 WP_000611328.1 1947216..1947872(+) (letA) [Escherichia coli strain ET881]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAGTGGTGTCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGTGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGACATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482