Detailed information NTG0594882

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HLV54_RS10050
• Genome accession: NZ_CP080770
• Coordinates: 2026008..2027051 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain HL23187
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2021008..2032051

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HLV54_RS10020 (HLV54_002004)	-	2021429..2022685 (-)	1257	WP_078065149.1	aminopeptidase	-
HLV54_RS10025 (HLV54_002005)	-	2022688..2022888 (-)	201	WP_000180460.1	DUF1128 family protein	-
HLV54_RS10030 (HLV54_002006)	-	2023035..2023499 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
HLV54_RS10035 (HLV54_002007)	-	2023506..2023781 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
HLV54_RS10040 (HLV54_002008)	-	2024059..2025276 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
HLV54_RS10045 (HLV54_002009)	vraR	2025389..2026018 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
HLV54_RS10050 (HLV54_002010)	vraS	2026008..2027051 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
HLV54_RS10055 (HLV54_002011)	liaF	2027048..2027749 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
HLV54_RS10060 (HLV54_002012)	-	2027764..2028150 (-)	387	WP_001110179.1	hypothetical protein	-
HLV54_RS10065 (HLV54_002013)	map	2028367..2029125 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
HLV54_RS10070 (HLV54_002014)	-	2029654..2030640 (+)	987	WP_000999708.1	aromatic acid exporter family protein	-
HLV54_RS10075 (HLV54_002015)	-	2031073..2031486 (-)	414	WP_025174552.1	hypothetical protein	-
HLV54_RS10080 (HLV54_002016)	-	2031515..2031625 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=594882 HLV54_RS10050 WP_001017131.1 2026008..2027051(-) (vraS) [Staphylococcus aureus strain HL23187]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=594882 HLV54_RS10050 WP_001017131.1 2026008..2027051(-) (vraS) [Staphylococcus aureus strain HL23187]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1