Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   HLV54_RS10045 Genome accession   NZ_CP080770
Coordinates   2025389..2026018 (-) Length   209 a.a.
NCBI ID   WP_000153526.1    Uniprot ID   -
Organism   Staphylococcus aureus strain HL23187     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2020389..2031018
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HLV54_RS10015 (HLV54_002003) - 2020809..2021339 (-) 531 WP_000184381.1 acyl-CoA thioesterase -
  HLV54_RS10020 (HLV54_002004) - 2021429..2022685 (-) 1257 WP_078065149.1 aminopeptidase -
  HLV54_RS10025 (HLV54_002005) - 2022688..2022888 (-) 201 WP_000180460.1 DUF1128 family protein -
  HLV54_RS10030 (HLV54_002006) - 2023035..2023499 (+) 465 WP_000228666.1 low molecular weight protein-tyrosine-phosphatase -
  HLV54_RS10035 (HLV54_002007) - 2023506..2023781 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  HLV54_RS10040 (HLV54_002008) - 2024059..2025276 (+) 1218 WP_000037087.1 YihY/virulence factor BrkB family protein -
  HLV54_RS10045 (HLV54_002009) vraR 2025389..2026018 (-) 630 WP_000153526.1 two-component system response regulator VraR Regulator
  HLV54_RS10050 (HLV54_002010) vraS 2026008..2027051 (-) 1044 WP_001017131.1 sensor histidine kinase Regulator
  HLV54_RS10055 (HLV54_002011) liaF 2027048..2027749 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  HLV54_RS10060 (HLV54_002012) - 2027764..2028150 (-) 387 WP_001110179.1 hypothetical protein -
  HLV54_RS10065 (HLV54_002013) map 2028367..2029125 (-) 759 WP_000636142.1 type I methionyl aminopeptidase -
  HLV54_RS10070 (HLV54_002014) - 2029654..2030640 (+) 987 WP_000999708.1 aromatic acid exporter family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23628.43 Da        Isoelectric Point: 5.6972

>NTDB_id=594881 HLV54_RS10045 WP_000153526.1 2025389..2026018(-) (vraR) [Staphylococcus aureus strain HL23187]
MTIKVLFVDDHEMVRIGISSYLSTQRDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=594881 HLV54_RS10045 WP_000153526.1 2025389..2026018(-) (vraR) [Staphylococcus aureus strain HL23187]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGGGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCCCATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAGTCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGCGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

99.522

100

0.995
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373