Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   CA347_RS10165 Genome accession   NC_021554
Coordinates   2022943..2023572 (-) Length   209 a.a.
NCBI ID   WP_000153535.1    Uniprot ID   W8TS97
Organism   Staphylococcus aureus CA-347     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 2017943..2028572
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  CA347_RS10135 (CA347_1965) - 2018363..2018893 (-) 531 WP_000184383.1 acyl-CoA thioesterase -
  CA347_RS10140 (CA347_1966) - 2018983..2020230 (-) 1248 WP_001622131.1 aminopeptidase -
  CA347_RS10145 (CA347_1967) - 2020242..2020442 (-) 201 WP_000180459.1 DUF1128 family protein -
  CA347_RS10150 (CA347_1968) - 2020589..2021053 (+) 465 WP_000228668.1 low molecular weight protein-tyrosine-phosphatase -
  CA347_RS10155 (CA347_1969) - 2021060..2021335 (+) 276 WP_000428172.1 YtxH domain-containing protein -
  CA347_RS10160 (CA347_1970) - 2021613..2022830 (+) 1218 WP_000037083.1 YihY/virulence factor BrkB family protein -
  CA347_RS10165 (CA347_1971) vraR 2022943..2023572 (-) 630 WP_000153535.1 two-component system response regulator VraR Regulator
  CA347_RS10170 (CA347_1972) vraS 2023562..2024605 (-) 1044 WP_016528753.1 sensor histidine kinase Regulator
  CA347_RS10175 (CA347_1973) liaF 2024602..2025303 (-) 702 WP_000149064.1 cell wall-active antibiotics response protein LiaF -
  CA347_RS10180 (CA347_1974) - 2025318..2025704 (-) 387 WP_001110184.1 hypothetical protein -
  CA347_RS10185 (CA347_1975) map 2025921..2026679 (-) 759 WP_000636137.1 type I methionyl aminopeptidase -
  CA347_RS10195 (CA347_1976) - 2027322..2028308 (+) 987 WP_000999713.1 FUSC family protein -

Sequence

Protein


Download         Length: 209 a.a.        Molecular weight: 23559.32 Da        Isoelectric Point: 5.3935

>NTDB_id=59326 CA347_RS10165 WP_000153535.1 2022943..2023572(-) (vraR) [Staphylococcus aureus CA-347]
MTIKVLFVDDHEMVRIGISSYLSTQSDIEVVGEGASGKEAIAKAHELKPDLILMDLLMEDMDGVEATTQIKKDLPQIKVL
MLTSFIEDKEVYRALDAGVDSYILKTTSAKDIADAVRKTSRGESVFEPEVLVKMRNRMKKRAELYEMLTEREMEILLLIA
KGYSNQEIASASHITIKTVKTHVSNILSKLEVQDRTQAVIYAFQHNLIQ

Nucleotide


Download         Length: 630 bp        

>NTDB_id=59326 CA347_RS10165 WP_000153535.1 2022943..2023572(-) (vraR) [Staphylococcus aureus CA-347]
ATGACGATTAAAGTATTGTTTGTGGATGATCATGAAATGGTACGTATAGGAATTTCAAGTTATCTATCAACGCAAAGTGA
TATTGAAGTAGTTGGTGAAGGCGCTTCTGGTAAAGAAGCAATTGCCAAAGCACATGAGTTGAAGCCAGATTTAATTTTAA
TGGATTTACTTATGGAAGACATGGATGGTGTAGAAGCGACGACTCAGATTAAAAAAGATTTACCGCAAATTAAAGTATTA
ATGTTAACTAGTTTTATTGAAGATAAAGAGGTATATCGTGCATTAGATGCAGGTGTCGATAGTTACATTTTAAAAACAAC
AAGTGCAAAAGATATCGCCGATGCAGTTCGTAAAACTTCTAGAGGAGAATCTGTTTTTGAACCGGAAGTTTTAGTGAAAA
TGCGTAACCGTATGAAAAAGCGTGCAGAGTTATATGAAATGCTTACAGAACGAGAAATGGAAATATTATTATTGATTGCG
AAAGGTTACTCAAATCAAGAAATTGCTAGTGCATCGCATATTACTATTAAAACGGTTAAGACACATGTGAGTAACATTTT
AAGTAAGTTAGAAGTGCAAGATAGAACACAAGCTGTTATCTATGCATTCCAACATAATTTAATTCAATAG

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-116)

Bacterial regulatory proteins, luxR family (GerE)

(147-202)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB W8TS97

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

100

100

1
  degU Bacillus subtilis subsp. subtilis str. 168

34.821

100

0.373

Multiple sequence alignment