Detailed information NTG0058553

Bioinformatically predicted

Overview

• Name: braR
• Type: Regulator
• Locus tag: MDRSPN_RS07090
• Genome accession: NZ_AP018391
• Coordinates: 1367451..1368128 (-)
• Length: 225 a.a.
• NCBI ID: WP_000548959.1
• Uniprot ID: Q9S1K2
• Organism: Streptococcus pneumoniae strain MDRSPN001
• Function: promote expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1362451..1373128

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MDRSPN_RS07055 (MDRSPN_01343)	-	1362614..1363243 (-)	630	WP_000762091.1	NAD(P)-dependent oxidoreductase	-
MDRSPN_RS07060 (MDRSPN_01344)	-	1363481..1363681 (+)	201	WP_001814296.1	hypothetical protein	-
MDRSPN_RS07070 (MDRSPN_01345)	-	1364111..1364251 (+)	141	WP_000422775.1	MazG-like protein	-
MDRSPN_RS07075	-	1364258..1364434 (+)	177	WP_000166031.1	MazG-like protein	-
MDRSPN_RS07080 (MDRSPN_01346)	thrS	1364492..1366435 (+)	1944	WP_000608349.1	threonine--tRNA ligase	-
MDRSPN_RS07085 (MDRSPN_01347)	-	1366484..1367458 (-)	975	WP_000887953.1	HAMP domain-containing histidine kinase	-
MDRSPN_RS07090 (MDRSPN_01348)	braR	1367451..1368128 (-)	678	WP_000548959.1	response regulator transcription factor	Regulator
MDRSPN_RS07095 (MDRSPN_01349)	-	1368284..1369357 (+)	1074	WP_001273823.1	DUF2974 domain-containing protein	-
MDRSPN_RS07100 (MDRSPN_01350)	-	1369448..1369750 (-)	303	WP_120164252.1	hypothetical protein	-
MDRSPN_RS07105 (MDRSPN_01351)	-	1369819..1370256 (-)	438	WP_120164253.1	Rrf2 family transcriptional regulator	-
MDRSPN_RS07110 (MDRSPN_01352)	-	1370332..1371174 (-)	843	WP_172581573.1	metallophosphoesterase	-
MDRSPN_RS07115 (MDRSPN_01353)	-	1371287..1371937 (+)	651	WP_120164255.1	metal-dependent transcriptional regulator	-
MDRSPN_RS11635	-	1371918..1372109 (+)	192	WP_001816503.1	hypothetical protein	-
MDRSPN_RS07125 (MDRSPN_01354)	-	1372135..1372810 (+)	676	Protein_1362	nicotinamide mononucleotide transporter	-
MDRSPN_RS11730	-	1372912..1372983 (+)	72	Protein_1363	glutamine ABC transporter permease	-

Sequence

Protein

• Length: 225 a.a.
• Molecular weight: 25964.16 Da
• Isoelectric Point: 5.1362

>NTDB_id=58553 MDRSPN_RS07090 WP_000548959.1 1367451..1368128(-) (braR) [Streptococcus pneumoniae strain MDRSPN001]
MHKILLIEDDQVIRQQIGKMLSEWGFEVVLVEDFMEVLSLFVQSEPHLVLMDIGLPLFNGYHWCQEIRKISKVPIMFLSS
RDQAMDIVMAINMGADDFVTKPFDQQVLLAKVQGLLRRSYEFGRDESLLEYAGVILNTKSMDLHYQGQVLNLTKNEFQIL
RVLFEHAGNIVARDDLMRELWNSDFFIDDNTLSVNVARLRKKLEEQGLVGFIETKKGIGYGLKHA

Nucleotide

• Length: 678 bp

>NTDB_id=58553 MDRSPN_RS07090 WP_000548959.1 1367451..1368128(-) (braR) [Streptococcus pneumoniae strain MDRSPN001]
ATGCACAAGATTTTATTAATAGAAGATGATCAGGTCATTCGTCAACAGATTGGGAAAATGCTCTCTGAATGGGGATTTGA
AGTGGTCCTGGTAGAAGACTTTATGGAAGTTTTGAGTCTATTTGTTCAGTCGGAACCTCATCTGGTCCTCATGGATATTG
GTTTGCCCTTGTTTAATGGTTATCACTGGTGTCAGGAAATCCGCAAGATTTCCAAGGTACCTATCATGTTTCTTTCTTCG
AGAGACCAGGCTATGGATATTGTCATGGCAATCAATATGGGGGCGGATGACTTTGTGACCAAGCCTTTTGACCAGCAGGT
TCTTTTAGCTAAGGTTCAGGGCTTGTTGCGTCGTTCCTATGAGTTTGGGCGTGATGAGAGTTTGCTGGAATATGCTGGTG
TTATCCTCAATACCAAATCCATGGATTTACATTATCAAGGGCAAGTCTTGAATTTGACCAAGAATGAATTCCAGATTTTA
CGCGTGTTATTTGAGCATGCAGGCAACATCGTAGCACGTGACGACCTGATGCGGGAACTTTGGAACAGTGACTTTTTCAT
TGATGATAATACCCTCTCTGTCAATGTGGCTCGTTTGCGTAAAAAGTTGGAGGAGCAGGGATTGGTAGGATTTATCGAGA
CCAAGAAAGGAATAGGGTACGGATTGAAGCATGCTTGA

Domains

Predicted by InterProScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (147-221)

3D structure

• AlphaFold DB: Q9S1K2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
braR	Staphylococcus aureus N315	48.624	96.889	0.471
vicR	Streptococcus mutans UA159	35.319	100	0.369