Detailed information NTG0585035

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU509_RS01990
• Genome accession: NZ_CP077917
• Coordinates: 375898..376941 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 280
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 370898..381941

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU509_RS01960 (KU509_01955)	-	371316..372572 (-)	1257	WP_001789555.1	aminopeptidase	-
KU509_RS01965 (KU509_01960)	-	372575..372775 (-)	201	WP_000180460.1	DUF1128 family protein	-
KU509_RS01970 (KU509_01965)	-	372922..373386 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU509_RS01975 (KU509_01970)	-	373393..373668 (+)	276	WP_000428171.1	hypothetical protein	-
KU509_RS01980 (KU509_01975)	-	373946..375163 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU509_RS01985 (KU509_01980)	vraR	375279..375908 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
KU509_RS01990 (KU509_01985)	vraS	375898..376941 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU509_RS01995 (KU509_01990)	liaF	376938..377639 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU509_RS02000 (KU509_01995)	-	377654..378040 (-)	387	WP_001110179.1	hypothetical protein	-
KU509_RS02005 (KU509_02000)	map	378257..379015 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU509_RS02010 (KU509_02005)	-	379546..380532 (+)	987	WP_000999716.1	FUSC family protein	-
KU509_RS02015 (KU509_02010)	-	381022..381435 (-)	414	WP_001670387.1	hypothetical protein	-
KU509_RS02020 (KU509_02015)	-	381464..381574 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=585035 KU509_RS01990 WP_001017131.1 375898..376941(-) (vraS) [Staphylococcus aureus strain 280]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=585035 KU509_RS01990 WP_001017131.1 375898..376941(-) (vraS) [Staphylococcus aureus strain 280]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1