Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   MDRSPN_RS00825 Genome accession   NZ_AP018391
Coordinates   151907..153856 (+) Length   649 a.a.
NCBI ID   WP_120164156.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain MDRSPN001     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 146907..158856
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MDRSPN_RS00795 (MDRSPN_00145) - 148335..149621 (+) 1287 WP_120164151.1 response regulator transcription factor -
  MDRSPN_RS00800 (MDRSPN_00146) - 149682..150215 (+) 534 WP_120164152.1 ABC transporter permease -
  MDRSPN_RS00805 (MDRSPN_00147) nrdI 150293..150757 (+) 465 WP_120164153.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  MDRSPN_RS00810 (MDRSPN_00148) - 150805..151263 (-) 459 WP_120164154.1 DUF3021 domain-containing protein -
  MDRSPN_RS00815 (MDRSPN_00149) - 151260..151700 (-) 441 WP_120164155.1 LytTR family DNA-binding domain-containing protein -
  MDRSPN_RS00825 (MDRSPN_00150) hexB 151907..153856 (+) 1950 WP_120164156.1 DNA mismatch repair endonuclease MutL Machinery gene
  MDRSPN_RS00830 (MDRSPN_00151) ruvA 153872..154465 (+) 594 WP_120164157.1 Holliday junction branch migration protein RuvA Machinery gene
  MDRSPN_RS00835 (MDRSPN_00152) - 154475..155038 (+) 564 WP_120164158.1 DNA-3-methyladenine glycosylase I -
  MDRSPN_RS00840 (MDRSPN_00153) - 155122..155385 (-) 264 WP_000166114.1 SemiSWEET family transporter -
  MDRSPN_RS00845 (MDRSPN_00154) - 155491..156525 (-) 1035 WP_049487390.1 S66 peptidase family protein -
  MDRSPN_RS00850 (MDRSPN_00155) - 156687..157034 (-) 348 WP_000331824.1 hypothetical protein -
  MDRSPN_RS00855 (MDRSPN_00156) - 157050..157727 (-) 678 WP_042751760.1 DUF1129 domain-containing protein -
  MDRSPN_RS00860 (MDRSPN_00157) - 157739..158683 (-) 945 WP_000815623.1 magnesium transporter CorA family protein -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73318.66 Da        Isoelectric Point: 5.2300

>NTDB_id=58497 MDRSPN_RS00825 WP_120164156.1 151907..153856(+) (hexB) [Streptococcus pneumoniae strain MDRSPN001]
MSHIIELPEVLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKIQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLASAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGYGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNRQKAEQTILPLKENTLYYEKTEPTRPSQAEVADYQVELADEGQDLTLFAKETLD
QLTKPAKLHFAERKPANYDQLDHPELDLASLDKAYDKLEREESSSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGDVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=58497 MDRSPN_RS00825 WP_120164156.1 151907..153856(+) (hexB) [Streptococcus pneumoniae strain MDRSPN001]
ATGTCTCATATTATTGAATTGCCAGAGGTGTTGGCAAACCAGATCGCGGCAGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCTATTGATGCGGGATCTAGTCAGATTATCATTGAGATTGAGGAAGCAGGTCTCAAGA
AGATTCAAATTACGGATAATGGTCACGGAATTGCCCACGATGAGGTAGAGCTGGCTCTGCGCCGCCATGCGACTAGTAAG
ATAAAAAATCAAGCAGACCTCTTTCGAATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATCGCTTCTGTTAG
TGTTCTGACTCTGTTAACGGCGGTGGATGGTGCAAGTCATGGGACTAAGTTAGTCGCGCGTGGAGGAGAAGTAGAAGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGACCTCTTTTTCAACACGCCTGCCCGCCTCAAATAT
ATGAAGAGCCAGCAAGCGGAGCTGTCTCATATCATTGATATCGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGTTTAATCAGTGATGGCAAGGAAATGACACGGACAGCTGGGACTGGGCAACTGCGCCAAGCTATTGCAGGGATTTATG
GTTTGGCGAGTGCTAAGAAGATGATTGAAATTGAGAACTCTGACTTAGATTTCGAAATTTCAGGTTTTGTGTCTCTGCCT
GAGTTAACTCGGGCTAATCGCAACTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTCTTGCTCAACCGTGC
TATTTTAGATGGTTATGGCAGCAAGCTTATGGTTGGCCGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCGACCAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACGCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAGCAAACCCTGATACCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TCAAAAGGCGGAGCAGACCATTCTCCCACTCAAAGAAAATACACTCTACTATGAGAAAACAGAGCCGACAAGACCAAGTC
AAGCTGAAGTAGCTGATTATCAGGTGGAATTGGCTGATGAAGGACAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CAATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTATGACCAACTAGACCATCCAGAGCTAGA
TCTAGCTAGTCTTGATAAGGCCTATGACAAGCTGGAGCGAGAAGAATCTTCAAGCTTCCCAGAGTTGGAATTTTTCGGGC
AAATGCACGGGACTTATCTCTTTGCCCAGGGGCGAGATGGGCTCTACATCATAGACCAGCACGCGGCTCAGGAACGGGTC
AAGTATGAGGAATACCGTGAAAGCATTGGCGATGTTGACCAGAGTCAGCAGCAACTCTTAGTACCTTATATCTTTGAATT
TCCTGCGGATGATGCCCTTCGTCTCAAGGAAAGAATGCCTCTTTTGGAGGAAGTGGGTGTCTTTCTAGCAGAGTACGGGG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAGGAGGAGATTGAGTCAGGTATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATATCGAGCAGAGTTGGCCATTATGATGTCCTGCAAGCGGTCTAT
CAAGGCCAACCATCGTATCGATGACCATTCGGCTAGACAACTCCTCTATCAACTTTCTCAATGTGACAATCCCTACAACT
GTCCCCACGGACGTCCTGTTTTGGTGCATTTCACTAAGTCGGATATGGAAAAGATGTTTCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAGTATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

97.997

100

0.98

Multiple sequence alignment