Detailed information NTG0584557

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: KU519_RS00890
• Genome accession: NZ_CP077888
• Coordinates: 147174..148217 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 334
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 142174..153217

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KU519_RS00860 (KU519_00865)	-	142592..143848 (-)	1257	WP_001795438.1	aminopeptidase	-
KU519_RS00865 (KU519_00870)	-	143851..144051 (-)	201	WP_000180461.1	DUF1128 family protein	-
KU519_RS00870 (KU519_00875)	-	144198..144662 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
KU519_RS00875 (KU519_00880)	-	144669..144944 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
KU519_RS00880 (KU519_00885)	-	145222..146439 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
KU519_RS00885 (KU519_00890)	vraR	146555..147184 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
KU519_RS00890 (KU519_00895)	vraS	147174..148217 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
KU519_RS00895 (KU519_00900)	liaF	148214..148915 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
KU519_RS00900 (KU519_00905)	-	148930..149316 (-)	387	WP_001110179.1	hypothetical protein	-
KU519_RS00905 (KU519_00910)	map	149533..150291 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
KU519_RS00910 (KU519_00915)	-	150878..151850 (+)	973	Protein_142	FUSC family protein	-
KU519_RS00915 (KU519_00920)	-	152281..152694 (-)	414	WP_001549145.1	hypothetical protein	-
KU519_RS00920 (KU519_00925)	-	152723..152833 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=584557 KU519_RS00890 WP_001017131.1 147174..148217(-) (vraS) [Staphylococcus aureus strain 334]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=584557 KU519_RS00890 WP_001017131.1 147174..148217(-) (vraS) [Staphylococcus aureus strain 334]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTGAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1