Detailed information    

insolico Bioinformatically predicted

Overview

Name   letA   Type   Regulator
Locus tag   MW404_RS12465 Genome accession   NZ_CP095520
Coordinates   2480643..2481299 (-) Length   218 a.a.
NCBI ID   WP_000611328.1    Uniprot ID   P66797
Organism   Escherichia coli strain GN04171     
Function   regulate competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2475643..2486299
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  MW404_RS12420 (MW404_12440) - 2475985..2476167 (+) 183 WP_000916334.1 hypothetical protein -
  MW404_RS12430 (MW404_12445) - 2476377..2476640 (+) 264 WP_000833838.1 DUF4224 domain-containing protein -
  MW404_RS12435 (MW404_12450) - 2476609..2477625 (+) 1017 WP_001531780.1 tyrosine-type recombinase/integrase -
  MW404_RS12455 (MW404_12470) pgsA 2478209..2478757 (-) 549 WP_001160187.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  MW404_RS12460 (MW404_12475) uvrC 2478814..2480646 (-) 1833 WP_001283421.1 excinuclease ABC subunit UvrC Machinery gene
  MW404_RS12465 (MW404_12480) letA 2480643..2481299 (-) 657 WP_000611328.1 UvrY/SirA/GacA family response regulator transcription factor Regulator
  MW404_RS12470 (MW404_12485) yecU 2481595..2481771 (+) 177 WP_001307856.1 protein YecU -
  MW404_RS12475 (MW404_12490) yecF 2481758..2481982 (+) 225 WP_000106474.1 DUF2594 family protein YecF -
  MW404_RS12480 (MW404_12495) sdiA 2482050..2482772 (-) 723 WP_001154255.1 transcriptional regulator SdiA -
  MW404_RS12485 (MW404_12500) tcyN 2483002..2483754 (-) 753 WP_001273000.1 L-cystine ABC transporter ATP-binding protein TcyN -
  MW404_RS12490 (MW404_12505) tcyL 2483751..2484419 (-) 669 WP_001158220.1 cystine ABC transporter permease -
  MW404_RS12495 (MW404_12510) dcyD 2484434..2485420 (-) 987 WP_001128232.1 D-cysteine desulfhydrase -

Sequence

Protein


Download         Length: 218 a.a.        Molecular weight: 23862.63 Da        Isoelectric Point: 6.9614

>NTDB_id=583584 MW404_RS12465 WP_000611328.1 2480643..2481299(-) (letA) [Escherichia coli strain GN04171]
MINVLLVDDHELVRAGIRRILEDIKGIKVVGEASCGEDAVKWCRANAVDVVLMDMSMPGIGGLEATRKIARSTADVKIIM
LTVHTENPLPAKVMQAGAAGYLSKGAAPQEVVSAIRSVYSGQRYIASDIAQQMALSQIEPEKTESPFASLSERELQIMLM
ITKGQKVNEISEQLNLSPKTVNSYRYRMFSKLNIHGDVELTHLAIRHGLCNAETLSSQ

Nucleotide


Download         Length: 657 bp        

>NTDB_id=583584 MW404_RS12465 WP_000611328.1 2480643..2481299(-) (letA) [Escherichia coli strain GN04171]
TTGATCAACGTTCTACTTGTTGATGACCACGAACTGGTGCGCGCAGGGATACGACGCATTCTGGAAGATATAAAGGGTAT
AAAAGTCGTCGGTGAGGCATCGTGCGGTGAAGACGCCGTTAAATGGTGCCGGGCAAATGCCGTTGACGTGGTGCTAATGG
ACATGAGTATGCCGGGCATTGGCGGTCTTGAGGCGACGCGTAAAATCGCGCGTTCCACAGCTGATGTCAAAATCATCATG
CTTACCGTCCATACAGAAAACCCTTTACCAGCGAAAGTCATGCAGGCCGGAGCTGCGGGCTACCTCAGCAAAGGCGCGGC
TCCGCAGGAAGTCGTGAGTGCGATTCGTTCTGTCTATTCAGGGCAGCGTTACATTGCTTCTGATATCGCTCAACAAATGG
CGTTAAGCCAGATCGAACCAGAAAAAACAGAAAGCCCATTTGCCAGTTTGTCTGAACGTGAATTGCAGATTATGCTGATG
ATCACCAAGGGCCAGAAGGTCAATGAGATCTCAGAACAGCTCAATCTCAGTCCGAAAACGGTGAACAGCTACCGCTATCG
TATGTTCAGTAAACTAAACATTCATGGCGATGTTGAGCTGACTCACCTGGCAATTCGCCATGGTCTGTGTAATGCGGAGA
CATTATCAAGTCAGTGA

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(149-204)

Response regulator receiver domain (Response_reg)

(4-115)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P66797

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  letA Legionella pneumophila str. Paris

50.725

94.954

0.482
  letA Legionella pneumophila strain ERS1305867

50.725

94.954

0.482