Detailed information NTG0057882

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: SPN032672_RS06040
• Genome accession: NC_021003
• Coordinates: 1128297..1129334 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae SPN032672
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1123297..1134334

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SPN032672_RS06000	yidC	1123332..1124258 (-)	927	WP_000835941.1	membrane protein insertase YidC	-
SPN032672_RS06005	-	1124336..1124614 (-)	279	WP_001174613.1	acylphosphatase	-
SPN032672_RS06010	-	1124648..1125388 (+)	741	WP_000152678.1	TrmH family RNA methyltransferase	-
SPN032672_RS06015	-	1125444..1126127 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
SPN032672_RS06025	asnA	1126239..1127231 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
SPN032672_RS06030	rsmD	1127296..1127835 (+)	540	WP_000706964.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
SPN032672_RS06035	coaD	1127825..1128313 (+)	489	WP_001280723.1	pantetheine-phosphate adenylyltransferase	-
SPN032672_RS06040	sepM	1128297..1129334 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
SPN032672_RS06045	-	1129392..1129622 (+)	231	WP_000250391.1	DUF1146 family protein	-
SPN032672_RS06050	murA	1129646..1130929 (+)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
SPN032672_RS06055	-	1130922..1131110 (+)	189	WP_001818955.1	DNA-directed RNA polymerase subunit beta	-
SPN032672_RS06060	endA	1131149..1131973 (+)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
SPN032672_RS06065	-	1132264..1133595 (+)	1332	WP_000390043.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=57882 SPN032672_RS06040 WP_000727277.1 1128297..1129334(+) (sepM) [Streptococcus pneumoniae SPN032672]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=57882 SPN032672_RS06040 WP_000727277.1 1128297..1129334(+) (sepM) [Streptococcus pneumoniae SPN032672]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGGAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591