Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   L3475_RS03185 Genome accession   NZ_CP091451
Coordinates   600292..602139 (+) Length   615 a.a.
NCBI ID   WP_001061144.1    Uniprot ID   B2IMT4
Organism   Streptococcus pneumoniae strain 3238/09     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 595292..607139
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L3475_RS03165 (L3475_03125) - 596124..596903 (+) 780 WP_000290013.1 alpha/beta hydrolase family protein -
  L3475_RS03170 (L3475_03130) murM 597015..598235 (+) 1221 WP_000286563.1 peptidoglycan bridge formation alanyltransferase MurM -
  L3475_RS03175 (L3475_03135) murN 598240..599472 (+) 1233 WP_001229509.1 peptidoglycan bridge formation alanyltransferase MurN -
  L3475_RS03180 (L3475_03140) - 599551..600252 (+) 702 WP_001267410.1 M57 family metalloprotease -
  L3475_RS03185 (L3475_03145) uvrC 600292..602139 (+) 1848 WP_001061144.1 excinuclease ABC subunit UvrC Machinery gene
  L3475_RS03190 (L3475_03150) - 602129..602962 (+) 834 Protein_626 metallophosphoesterase family protein -
  L3475_RS03195 (L3475_03155) - 603146..603946 (-) 801 WP_000714633.1 amino acid ABC transporter substrate-binding protein -
  L3475_RS03200 (L3475_03160) - 604117..604722 (+) 606 WP_000670163.1 nitroreductase family protein -
  L3475_RS03205 (L3475_03165) pepV 604735..606135 (+) 1401 WP_000125044.1 dipeptidase PepV -
  L3475_RS03210 (L3475_03170) - 606189..606767 (+) 579 WP_000078149.1 uracil-DNA glycosylase family protein -

Sequence

Protein


Download         Length: 615 a.a.        Molecular weight: 70595.25 Da        Isoelectric Point: 9.2183

>NTDB_id=561503 L3475_RS03185 WP_001061144.1 600292..602139(+) (uvrC) [Streptococcus pneumoniae strain 3238/09]
MNNLIKSKLELLPTSPGCYIHKDKNGTIIYVGKAKNLRNRVRSYFRGSHDTKTEALVSEIVDFEFIVTESNIEALLLEIN
LIKENKPKYNIMLKDDKSYPFIKITNERYPRLIITRQVKKDGGLYFGPYPDVGAANEIKRLLDRIFPFRKCTNPPSKVCF
YYHIGQCMAHTICKKDEIYFKSMAQEVSDFLKGQDNKIIDELKGKMAAAAQTMEFERAAEYRDLIQAIGTLRTKQRVMAK
DLQNRDVFGYYVDKGWMCVQVFFVRQGKLIERDVNLFPYFNDPDEDFLTYVGQFYQEKSHLVPNEVLIPQDIDEEAVKAL
VDSKILKPQRGEKKQLVNLAIKNARVSLEQKFNLLEKSVEKTQGAIENLGRLLQIPTPVRIESFDNSNIMGTSPVSAMVV
FVNGKPSKKDYRKYKIKTVVGPDDYASMREVIRRRYGRVQREALTPPDLIVIDGGQGQVNIAKQVIQEELGLDIPIAGLQ
KNDKHQTHELLFGDPLEVVDLSRNSQEFFLLQRIQDEVHRFAITFHRQLRSKNSFSSQLDGIDGLGPKRKQNLMRHFKSL
TKIKEASVDEIVEVGVPRAVAEAVQTKLNPQETEILLQVAEERVDYQTEGNHNKP

Nucleotide


Download         Length: 1848 bp        

>NTDB_id=561503 L3475_RS03185 WP_001061144.1 600292..602139(+) (uvrC) [Streptococcus pneumoniae strain 3238/09]
ATGAACAACTTGATTAAATCAAAACTAGAGCTCTTGCCGACCAGCCCTGGTTGCTACATTCATAAGGATAAAAATGGCAC
CATTATCTATGTAGGAAAGGCTAAAAATCTGCGTAATCGAGTACGGTCCTATTTTCGTGGAAGTCATGATACCAAGACAG
AGGCTCTGGTGTCTGAAATTGTGGATTTTGAATTTATTGTTACGGAGTCTAATATTGAGGCACTTCTCCTAGAAATCAAC
CTGATCAAGGAAAACAAGCCCAAGTACAATATCATGCTCAAGGATGACAAGTCCTATCCTTTCATCAAAATCACCAATGA
GCGCTATCCACGCTTGATTATCACTCGTCAGGTCAAAAAGGACGGAGGTCTTTATTTTGGACCCTATCCCGATGTGGGGG
CAGCCAATGAAATCAAGCGGTTGCTGGATCGGATATTCCCTTTTCGTAAGTGTACCAACCCGCCCTCTAAGGTCTGTTTT
TATTACCATATCGGTCAATGCATGGCCCACACCATCTGTAAGAAGGATGAGATTTATTTCAAGTCTATGGCCCAGGAGGT
TTCTGATTTTCTGAAAGGGCAGGATAACAAAATCATTGATGAGCTAAAGGGCAAAATGGCAGCGGCAGCCCAGACTATGG
AGTTTGAACGTGCGGCGGAATACCGTGACCTGATTCAGGCTATTGGAACGCTTCGAACCAAGCAACGGGTCATGGCTAAG
GATCTCCAAAATCGCGATGTCTTTGGCTACTATGTGGATAAGGGCTGGATGTGTGTGCAGGTTTTCTTTGTCCGTCAGGG
TAAGCTCATCGAGCGCGATGTCAATCTCTTCCCCTACTTCAATGATCCAGATGAGGATTTTTTGACCTATGTAGGACAAT
TCTATCAAGAAAAATCCCATCTAGTTCCCAATGAGGTACTGATTCCGCAAGATATTGACGAAGAGGCTGTCAAGGCCTTG
GTGGATTCCAAGATTCTTAAGCCTCAACGTGGAGAGAAAAAGCAGCTGGTCAATTTAGCTATAAAAAATGCCCGTGTTAG
CCTAGAGCAGAAGTTCAACCTGCTAGAGAAATCTGTCGAGAAGACCCAAGGAGCTATTGAAAATCTAGGACGCTTGCTTC
AAATCCCAACCCCAGTTCGCATCGAGTCCTTCGATAACTCCAACATCATGGGAACTAGTCCTGTTTCAGCCATGGTGGTC
TTTGTCAACGGCAAGCCTAGTAAGAAGGATTACCGTAAGTATAAAATCAAGACCGTAGTCGGGCCAGACGACTATGCCAG
TATGCGAGAGGTCATTCGCAGACGCTATGGTCGAGTACAGCGTGAGGCTTTGACTCCTCCAGATTTGATTGTGATTGATG
GGGGGCAAGGTCAAGTCAATATTGCTAAGCAAGTCATCCAAGAAGAACTGGGCTTGGATATTCCAATTGCAGGTCTGCAA
AAGAATGATAAGCACCAAACCCATGAATTGCTCTTTGGAGATCCGCTGGAAGTGGTGGACTTGTCTCGCAATTCTCAGGA
ATTTTTCCTCCTCCAACGCATTCAAGATGAGGTCCACCGCTTTGCCATTACCTTCCACCGCCAACTGCGCTCCAAAAATT
CTTTCTCATCTCAATTGGATGGGATTGATGGTCTGGGACCTAAACGCAAGCAAAATCTCATGAGGCACTTCAAGTCTCTG
ACCAAAATCAAGGAAGCCAGTGTGGATGAGATTGTCGAAGTTGGAGTACCAAGAGCAGTAGCAGAGGCTGTGCAAACCAA
GTTGAACCCGCAGGAAACAGAAATCTTGCTTCAAGTGGCGGAAGAAAGAGTAGATTACCAAACGGAAGGAAACCACAATA
AACCATAA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(197-228)

GIY-YIG catalytic domain (GIY-YIG)

(17-90)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(372-523)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B2IMT4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae R6

97.724

100

0.977
  uvrC Streptococcus pneumoniae D39

97.724

100

0.977
  uvrC Streptococcus pneumoniae TIGR4

97.724

100

0.977