Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | KFV42_RS12660 | Genome accession | NZ_CP073836 |
| Coordinates | 2603950..2605578 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186596.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain B1262351 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2602583..2651244 | 2603950..2605578 | within | 0 |
Gene organization within MGE regions
Location: 2602583..2651244
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV42_RS12655 (KFV42_12665) | ccrA | 2602583..2603929 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV42_RS12660 (KFV42_12670) | ccrB | 2603950..2605578 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV42_RS12665 (KFV42_12675) | - | 2606049..2606399 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV42_RS12670 (KFV42_12680) | - | 2606484..2606795 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV42_RS12675 (KFV42_12685) | - | 2606814..2607335 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV42_RS12680 (KFV42_12690) | - | 2607337..2607543 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV42_RS12685 (KFV42_12695) | - | 2607536..2607859 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV42_RS12690 (KFV42_12700) | - | 2608054..2609946 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV42_RS12695 (KFV42_12705) | - | 2609953..2610330 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV42_RS12700 (KFV42_12710) | - | 2610568..2610933 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV42_RS12705 (KFV42_12715) | - | 2610926..2613340 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV42_RS12710 (KFV42_12720) | - | 2613421..2614037 (+) | 617 | Protein_2485 | CadD family cadmium resistance transporter | - |
| KFV42_RS12720 (KFV42_12730) | - | 2614311..2614949 (-) | 639 | Protein_2486 | sulfite exporter TauE/SafE family protein | - |
| KFV42_RS12725 (KFV42_12735) | cstR | 2614949..2615209 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV42_RS12730 (KFV42_12740) | - | 2615345..2616409 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV42_RS12735 (KFV42_12745) | cstB | 2616442..2617776 (+) | 1335 | Protein_2489 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV42_RS12740 (KFV42_12750) | - | 2617890..2618999 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV42_RS12745 (KFV42_12755) | psm-mec | 2619354..2619422 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV42_RS12750 (KFV42_12760) | mecI | 2619507..2619878 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV42_RS12755 (KFV42_12765) | mecR1 | 2619878..2621635 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV42_RS12760 (KFV42_12770) | mecA | 2621732..2623741 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV42_RS12765 (KFV42_12775) | - | 2623787..2624215 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV42_RS12770 (KFV42_12780) | - | 2624312..2625055 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV42_RS12775 (KFV42_12785) | - | 2625852..2626241 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV42_RS12780 (KFV42_12790) | - | 2626277..2626951 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV42_RS12785 (KFV42_12795) | - | 2627396..2628652 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV42_RS12790 (KFV42_12800) | - | 2629095..2629640 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV42_RS12795 (KFV42_12805) | - | 2629658..2629867 (-) | 210 | Protein_2501 | heavy metal translocating P-type ATPase | - |
| KFV42_RS12800 (KFV42_12810) | - | 2630037..2630795 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV42_RS12805 (KFV42_12815) | - | 2630792..2630947 (-) | 156 | Protein_2503 | metal-sensing transcriptional repressor | - |
| KFV42_RS12815 (KFV42_12825) | - | 2631170..2631460 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV42_RS12820 (KFV42_12830) | - | 2631512..2632384 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV42_RS12825 (KFV42_12835) | - | 2632554..2633000 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV42_RS12830 (KFV42_12840) | - | 2633028..2633534 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV42_RS12835 (KFV42_12845) | - | 2633550..2633861 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV42_RS12840 (KFV42_12850) | - | 2633957..2634295 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV42_RS12845 (KFV42_12855) | - | 2634401..2636077 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV42_RS12850 (KFV42_12860) | - | 2636304..2637947 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV42_RS12855 (KFV42_12865) | - | 2637944..2638315 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV42_RS12860 (KFV42_12870) | - | 2638308..2639408 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV42_RS12865 (KFV42_12875) | - | 2639635..2641110 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV42_RS12870 (KFV42_12880) | - | 2641218..2642081 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV42_RS12875 (KFV42_12885) | - | 2642279..2642584 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV42_RS12880 (KFV42_12890) | - | 2643836..2645761 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV42_RS12885 (KFV42_12895) | - | 2646091..2646417 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV42_RS12890 (KFV42_12900) | - | 2646624..2646983 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV42_RS12895 (KFV42_12905) | - | 2647095..2647433 (-) | 339 | Protein_2520 | recombinase family protein | - |
| KFV42_RS12900 (KFV42_12910) | - | 2647442..2648071 (+) | 630 | Protein_2521 | hypothetical protein | - |
| KFV42_RS12905 (KFV42_12915) | ccrA | 2648258..2649619 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV42_RS12910 (KFV42_12920) | ccrB | 2649616..2651244 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62274.15 Da Isoelectric Point: 9.7334
>NTDB_id=561223 KFV42_RS12660 WP_001186596.1 2603950..2605578(+) (ccrB) [Staphylococcus epidermidis strain B1262351]
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
MQQLKQKRVGIYVRVSTEIQSTEGYSIDGQINQIREYCDFNNFVVVDVYADRGISGKSMNRPELQRLLKDANEGQIDSVM
VYKTNRLARNTSDLLKIVEDLHRQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSIGSVTYILSNPFYVGKIQFAK
YKDWNEKRRKGLNDKPIIAEGKHSPIIIQDLWDKVQLRKKQVSQKPQVHGKGTNLLTGIVHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEKYVMDQILEIVKSDKVINQVLERVNQENKVDIGALNHDIAYKQQQYD
EVSGKLHNLVKTIEDNPDLTSALKATIHQYETQLNDITNQMNQLKQQQNQEKLSYDTKQIAALLQRIFQNIESMDKAQLK
ALYLTVIDRIDIRKDGNHKKQFYVTLKLNNEIIKQLFNNTPLDEVLLSTSSLFLPQTLFLQI
Nucleotide
Download Length: 1629 bp
>NTDB_id=561223 KFV42_RS12660 WP_001186596.1 2603950..2605578(+) (ccrB) [Staphylococcus epidermidis strain B1262351]
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
ATGCAACAACTCAAACAAAAACGTGTCGGTATCTATGTTCGTGTATCAACGGAAATCCAAAGTACTGAAGGCTATAGTAT
CGATGGACAAATCAATCAAATTCGAGAATATTGTGATTTCAATAACTTTGTTGTTGTAGATGTATACGCGGATAGAGGTA
TCTCTGGAAAATCTATGAACCGACCAGAACTACAACGTTTGTTAAAAGATGCGAACGAAGGTCAGATTGATTCTGTTATG
GTCTACAAAACAAACCGACTAGCACGTAACACTTCTGACTTACTCAAAATTGTTGAAGACCTTCATCGTCAAAATGTCGA
ATTCTTCAGCTTATCTGAGCGTATGGAAGTCAATACAAGCAGTGGTAAATTGATGCTACAAATTCTAGCGAGTTTTTCAG
AATTTGAAAGAAATAATATTGTCGAAAATGTATTCATGGGTCAAACCCGACGCGCTCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCGGATAGCAAGCATGAACTCATGATAAACCAACATGAAGCGAATATTGTCAAATA
TATATTTGAGTCATATGCTAAAGGCCACGGATATCGTAAAATTGCGAATGCACTCAATCACAAAGGATACGTGACTAAAA
AAGGAAAGCCTTTCAGTATTGGTTCAGTGACCTATATCTTATCTAATCCATTCTATGTTGGTAAAATTCAATTCGCAAAG
TACAAAGATTGGAATGAAAAGCGTCGTAAAGGGCTGAATGATAAACCAATAATAGCTGAAGGTAAGCATTCCCCTATTAT
TATTCAAGACTTATGGGATAAAGTCCAATTACGTAAAAAACAAGTCAGTCAAAAACCTCAAGTCCACGGTAAAGGAACTA
ATCTATTAACAGGTATCGTTCATTGTCCACAATGTGGTGCACCAATGGCAGCTAGTAACACAACGAACACATTGAAAGAT
GGTACCAAGAAGCGAATACGTTATTATTCTTGCAGTAACTTCCGAAACAAAGGCTCAAAAGTATGTTCTGCGAATAGCGT
TAGAGCTGATGTGATTGAGAAATACGTCATGGATCAAATACTCGAAATTGTCAAAAGTGATAAAGTCATTAACCAAGTCT
TAGAACGTGTCAATCAAGAAAATAAAGTCGATATTGGTGCATTGAACCACGATATCGCTTATAAACAACAACAATACGAT
GAAGTCAGCGGGAAACTCCATAATTTAGTTAAAACCATTGAAGATAATCCGGACCTAACATCTGCATTGAAAGCAACTAT
TCATCAATATGAAACACAACTCAATGACATTACAAATCAAATGAATCAACTCAAACAGCAACAAAATCAAGAGAAACTAT
CTTATGATACGAAACAAATCGCTGCCCTATTACAACGAATATTTCAAAATATAGAATCAATGGATAAAGCACAACTCAAA
GCATTATATCTTACAGTCATTGACCGTATTGATATTCGTAAAGACGGTAATCATAAAAAACAGTTCTACGTTACACTAAA
ACTCAATAATGAAATTATTAAACAACTTTTCAATAATACCCCTCTCGACGAAGTGCTCCTCAGCACTTCGTCTTTATTTT
TGCCTCAAACGCTCTTTCTTCAAATCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
86.531 |
100 |
0.865 |