Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | KFV28_RS12665 | Genome accession | NZ_CP073824 |
| Coordinates | 2599932..2601278 (+) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain B1200599 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 2599932..2648593 | 2599932..2601278 | within | 0 |
Gene organization within MGE regions
Location: 2599932..2648593
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KFV28_RS12665 (KFV28_12675) | ccrA | 2599932..2601278 (+) | 1347 | WP_000816499.1 | recombinase family protein | Machinery gene |
| KFV28_RS12670 (KFV28_12680) | ccrB | 2601299..2602927 (+) | 1629 | WP_001186596.1 | recombinase family protein | Machinery gene |
| KFV28_RS12675 (KFV28_12685) | - | 2603398..2603748 (+) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV28_RS12680 (KFV28_12690) | - | 2603833..2604144 (+) | 312 | WP_000833212.1 | DUF960 family protein | - |
| KFV28_RS12685 (KFV28_12695) | - | 2604163..2604684 (+) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| KFV28_RS12690 (KFV28_12700) | - | 2604686..2604892 (+) | 207 | WP_001077283.1 | hypothetical protein | - |
| KFV28_RS12695 (KFV28_12705) | - | 2604885..2605208 (+) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| KFV28_RS12700 (KFV28_12710) | - | 2605403..2607295 (+) | 1893 | WP_002485298.1 | site-specific integrase | - |
| KFV28_RS12705 (KFV28_12715) | - | 2607302..2607679 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| KFV28_RS12710 (KFV28_12720) | - | 2607917..2608282 (+) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV28_RS12715 (KFV28_12725) | - | 2608275..2610689 (+) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| KFV28_RS12720 (KFV28_12730) | - | 2610770..2611386 (+) | 617 | Protein_2488 | CadD family cadmium resistance transporter | - |
| KFV28_RS12730 (KFV28_12740) | - | 2611660..2612298 (-) | 639 | Protein_2489 | sulfite exporter TauE/SafE family protein | - |
| KFV28_RS12735 (KFV28_12745) | cstR | 2612298..2612558 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| KFV28_RS12740 (KFV28_12750) | - | 2612694..2613758 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| KFV28_RS12745 (KFV28_12755) | cstB | 2613791..2615125 (+) | 1335 | Protein_2492 | persulfide dioxygenase-sulfurtransferase CstB | - |
| KFV28_RS12750 (KFV28_12760) | - | 2615239..2616348 (-) | 1110 | WP_000943131.1 | ROK family transcriptional regulator | - |
| KFV28_RS12755 (KFV28_12765) | psm-mec | 2616703..2616771 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| KFV28_RS12760 (KFV28_12770) | mecI | 2616856..2617227 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| KFV28_RS12765 (KFV28_12775) | mecR1 | 2617227..2618984 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| KFV28_RS12770 (KFV28_12780) | mecA | 2619081..2621090 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| KFV28_RS12775 (KFV28_12785) | - | 2621136..2621564 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| KFV28_RS12780 (KFV28_12790) | - | 2621661..2622404 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| KFV28_RS12785 (KFV28_12795) | - | 2623201..2623590 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| KFV28_RS12790 (KFV28_12800) | - | 2623626..2624300 (+) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| KFV28_RS12795 (KFV28_12805) | - | 2624745..2626001 (-) | 1257 | WP_000566670.1 | DUF3578 domain-containing protein | - |
| KFV28_RS12800 (KFV28_12810) | - | 2626444..2626989 (-) | 546 | WP_031869236.1 | YdhK family protein | - |
| KFV28_RS12805 (KFV28_12815) | - | 2627007..2627216 (-) | 210 | Protein_2504 | heavy metal translocating P-type ATPase | - |
| KFV28_RS12810 (KFV28_12820) | - | 2627386..2628144 (-) | 759 | WP_000623679.1 | sulfite exporter TauE/SafE family protein | - |
| KFV28_RS12815 (KFV28_12825) | - | 2628141..2628296 (-) | 156 | Protein_2506 | metal-sensing transcriptional repressor | - |
| KFV28_RS12825 (KFV28_12835) | - | 2628519..2628809 (-) | 291 | WP_012086558.1 | hypothetical protein | - |
| KFV28_RS12830 (KFV28_12840) | - | 2628861..2629733 (-) | 873 | WP_012086560.1 | HTH domain-containing protein | - |
| KFV28_RS12835 (KFV28_12845) | - | 2629903..2630349 (-) | 447 | WP_012086562.1 | JAB domain-containing protein | - |
| KFV28_RS12840 (KFV28_12850) | - | 2630377..2630883 (-) | 507 | WP_012086564.1 | DUF1643 domain-containing protein | - |
| KFV28_RS12845 (KFV28_12855) | - | 2630899..2631210 (-) | 312 | WP_001083109.1 | DUF960 family protein | - |
| KFV28_RS12850 (KFV28_12860) | - | 2631306..2631644 (-) | 339 | WP_012086569.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| KFV28_RS12855 (KFV28_12865) | - | 2631750..2633426 (-) | 1677 | WP_012086571.1 | recombinase family protein | - |
| KFV28_RS12860 (KFV28_12870) | - | 2633653..2635296 (-) | 1644 | WP_012086574.1 | DUF5906 domain-containing protein | - |
| KFV28_RS12865 (KFV28_12875) | - | 2635293..2635664 (-) | 372 | WP_001058157.1 | hypothetical protein | - |
| KFV28_RS12870 (KFV28_12880) | - | 2635657..2636757 (-) | 1101 | WP_000449985.1 | DNA polymerase | - |
| KFV28_RS12875 (KFV28_12885) | - | 2636984..2638459 (-) | 1476 | WP_001138664.1 | DUF6038 family protein | - |
| KFV28_RS12880 (KFV28_12890) | - | 2638567..2639430 (-) | 864 | WP_000680579.1 | hypothetical protein | - |
| KFV28_RS12885 (KFV28_12895) | - | 2639628..2639933 (-) | 306 | WP_000677987.1 | hypothetical protein | - |
| KFV28_RS12890 (KFV28_12900) | - | 2641185..2643110 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| KFV28_RS12895 (KFV28_12905) | - | 2643440..2643766 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| KFV28_RS12900 (KFV28_12910) | - | 2643973..2644332 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| KFV28_RS12905 (KFV28_12915) | - | 2644444..2644782 (-) | 339 | Protein_2523 | recombinase family protein | - |
| KFV28_RS12910 (KFV28_12920) | - | 2644791..2645420 (+) | 630 | Protein_2524 | hypothetical protein | - |
| KFV28_RS12915 (KFV28_12925) | ccrA | 2645607..2646968 (+) | 1362 | WP_001631036.1 | recombinase family protein | Machinery gene |
| KFV28_RS12920 (KFV28_12930) | ccrB | 2646965..2648593 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=561070 KFV28_RS12665 WP_000816499.1 2599932..2601278(+) (ccrA) [Staphylococcus epidermidis strain B1200599]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=561070 KFV28_RS12665 WP_000816499.1 2599932..2601278(+) (ccrA) [Staphylococcus epidermidis strain B1200599]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |