Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   L1A14_RS02185 Genome accession   NZ_CP090883
Coordinates   410270..410902 (+) Length   210 a.a.
NCBI ID   WP_000698438.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain LE4448     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 405270..415902
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L1A14_RS02160 (L1A14_02160) mvaD 405547..406500 (+) 954 WP_000373456.1 diphosphomevalonate decarboxylase -
  L1A14_RS02165 (L1A14_02165) - 406487..407494 (+) 1008 WP_000562427.1 phosphomevalonate kinase -
  L1A14_RS02170 (L1A14_02170) fni 407478..408488 (+) 1011 WP_000210616.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  L1A14_RS02175 (L1A14_02175) liaF 408566..409264 (+) 699 WP_001224637.1 cell wall-active antibiotics response protein LiaF -
  L1A14_RS02180 (L1A14_02180) - 409261..410256 (+) 996 WP_000743662.1 sensor histidine kinase -
  L1A14_RS02185 (L1A14_02185) vraR 410270..410902 (+) 633 WP_000698438.1 response regulator transcription factor Regulator
  L1A14_RS02190 (L1A14_02190) - 410978..411672 (+) 695 Protein_417 DNA alkylation repair protein -
  L1A14_RS02195 (L1A14_02195) - 411822..412061 (+) 240 WP_000754501.1 hypothetical protein -
  L1A14_RS02200 (L1A14_02200) cbpG 412142..412732 (+) 591 Protein_419 choline-binding protein CbpG -
  L1A14_RS02205 (L1A14_02205) - 413034..413426 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  L1A14_RS02210 (L1A14_02210) tig 413587..414870 (+) 1284 WP_000116468.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23583.06 Da        Isoelectric Point: 4.5791

>NTDB_id=556472 L1A14_RS02185 WP_000698438.1 410270..410902(+) (vraR) [Streptococcus pneumoniae strain LE4448]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQATVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=556472 L1A14_RS02185 WP_000698438.1 410270..410902(+) (vraR) [Streptococcus pneumoniae strain LE4448]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGACTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-114)

Bacterial regulatory proteins, luxR family (GerE)

(145-199)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41