Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SMUNUM_RS10030 Genome accession   NZ_AP014571
Coordinates   2022144..2024099 (-) Length   651 a.a.
NCBI ID   WP_019805529.1    Uniprot ID   -
Organism   Streptococcus mutans LP13     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2017144..2029099
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUNUM_RS10005 (SMNUM_1897) spx 2017643..2018041 (-) 399 WP_002262391.1 transcriptional regulator Spx -
  SMUNUM_RS10010 (SMNUM_1898) recA 2018126..2019277 (-) 1152 WP_002262392.1 recombinase RecA Machinery gene
  SMUNUM_RS10015 (SMNUM_1899) cinA 2019317..2020573 (-) 1257 WP_002270966.1 competence/damage-inducible protein A Machinery gene
  SMUNUM_RS10020 (SMNUM_1900) - 2020722..2021282 (-) 561 WP_002268198.1 DNA-3-methyladenine glycosylase I -
  SMUNUM_RS10025 (SMNUM_1901) ruvA 2021364..2021957 (-) 594 WP_002266975.1 Holliday junction branch migration protein RuvA Machinery gene
  SMUNUM_RS10030 (SMNUM_1902) hexB 2022144..2024099 (-) 1956 WP_019805529.1 DNA mismatch repair endonuclease MutL Machinery gene
  SMUNUM_RS10035 - 2024324..2024602 (+) 279 Protein_1926 transposase -
  SMUNUM_RS10040 (SMNUM_1903) hexA 2024597..2027146 (-) 2550 WP_002262398.1 DNA mismatch repair protein MutS Machinery gene
  SMUNUM_RS10045 (SMNUM_1904) - 2027139..2027486 (-) 348 WP_002297103.1 YlbF family regulator -
  SMUNUM_RS10050 (SMNUM_1905) argR 2027483..2027920 (-) 438 WP_002262400.1 arginine repressor -
  SMUNUM_RS10055 (SMNUM_1906) - 2028317..2028841 (-) 525 WP_002270968.1 Crp/Fnr family transcriptional regulator -

Sequence

Protein


Download         Length: 651 a.a.        Molecular weight: 73795.48 Da        Isoelectric Point: 6.4647

>NTDB_id=55605 SMUNUM_RS10030 WP_019805529.1 2022144..2024099(-) (hexB) [Streptococcus mutans LP13]
MSKIIELPEVLANQIAAGEVIERPASVVKELVENAIDADSSQITIEIEESGLKKIQVIDNGQGIEQADVIMSLRRHATSK
IKKQSDLFRIRTLGFRGEALPSIASISRLTLKTATKGEIHGTLVIANGGKIEKEEAISTPIGTKVSVENLFFNTPARLKY
MKSLQAELAHIIDVINRLSLAHPEIAFTLINDGRELTKTSGKGDLRHALAGIYGVTTAKKMVEISNADLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIQIDPYLADVNVHPTKQEVRISKEKELMNLISS
AIADSLREQELIPDALENLAKTSTNKKQKFEQTQLPLKQSNLYYDKTQNDFFLKETTVSEASSEFTVVDKAVNITDNVSG
HSSVKYAQRQMRTCENKEHPSLTMTDKQQKRQLSRIVESLENEEKSTFPELEYFGQMHGTYLFAQGEGGLYIIDQHAAQE
RVKYEYYRDKIGEVDNSLQQLLVPYLFEFPANDFMTLQEKMSILNEVGVHLENYGENTFILREHPIWLQEKEIESAVYEM
CDMLLLTNEVSIKKYRAELAIMMSCKRSIKANHTLDDYSARNLLIQLSQCKNPYNCPHGRPVLVNFTKADMEKMFRRIQE
NHTSLRELGKY

Nucleotide


Download         Length: 1956 bp        

>NTDB_id=55605 SMUNUM_RS10030 WP_019805529.1 2022144..2024099(-) (hexB) [Streptococcus mutans LP13]
ATGTCAAAAATTATTGAACTGCCAGAAGTTTTAGCCAATCAAATTGCTGCTGGAGAGGTTATTGAAAGACCAGCTAGTGT
CGTAAAAGAACTAGTTGAGAATGCTATTGACGCTGATAGCAGCCAAATTACAATAGAAATTGAAGAATCAGGACTGAAAA
AAATTCAAGTGATTGATAATGGTCAAGGAATAGAACAAGCGGATGTAATTATGAGCTTACGTCGCCATGCAACTAGTAAG
ATTAAAAAACAATCCGATCTTTTTAGAATTAGGACCTTAGGTTTTAGAGGTGAGGCCCTTCCATCAATTGCTTCTATTAG
CAGACTAACATTAAAAACAGCAACAAAAGGGGAAATACATGGCACTTTAGTAATCGCAAATGGAGGTAAAATTGAAAAAG
AAGAAGCCATTAGTACCCCTATTGGAACCAAAGTGAGTGTTGAAAATCTTTTCTTCAATACCCCTGCTCGCCTTAAATAT
ATGAAAAGTTTGCAGGCAGAGCTTGCTCATATTATTGATGTTATTAACCGTCTTAGCTTGGCGCATCCCGAAATTGCTTT
CACGCTTATTAATGATGGCCGTGAATTAACAAAGACGTCAGGTAAAGGCGATCTGCGTCACGCTTTAGCAGGTATTTATG
GGGTAACCACTGCTAAAAAAATGGTCGAAATTTCAAATGCAGATCTTGATTTTGAGGTATCTGGTTATATTAGTTTGCCT
GAATTAACCCGAGCTAATCGCAATTATATTACCATTCTTATTAATGGGCGTTATATCAAAAATTTTTTGCTCAATCGTGC
TATTCTTGATGGTTATGGTTCAAAATTAATGGTGGGACGTTTTCCAATTGCTGTTATTGATATTCAGATTGACCCTTACT
TAGCAGATGTTAATGTTCATCCAACTAAGCAGGAAGTTCGTATTTCTAAAGAAAAAGAGTTAATGAATCTCATTAGTTCG
GCAATTGCAGATAGTTTAAGAGAACAAGAGTTAATTCCTGATGCTTTGGAAAATCTTGCTAAAACTAGCACAAACAAGAA
ACAAAAGTTTGAACAAACACAACTTCCTCTTAAACAATCAAATCTTTACTATGATAAGACTCAAAATGACTTCTTTCTCA
AAGAAACGACAGTTTCAGAAGCATCAAGCGAGTTTACAGTAGTTGATAAAGCTGTAAATATTACTGATAATGTATCAGGA
CATAGCAGTGTAAAATATGCTCAACGTCAAATGAGAACTTGTGAAAACAAAGAGCATCCAAGTCTTACTATGACAGATAA
GCAACAAAAGCGACAGCTTAGTAGAATTGTTGAAAGTCTAGAAAATGAAGAAAAGTCAACTTTTCCTGAGTTAGAATATT
TTGGTCAAATGCATGGAACTTACCTCTTTGCTCAAGGTGAAGGGGGGCTTTATATTATAGATCAACATGCTGCTCAAGAA
CGTGTTAAATATGAATATTATCGTGATAAAATTGGAGAAGTAGACAATAGTTTACAGCAGCTTTTAGTACCTTATCTTTT
TGAATTTCCTGCTAATGATTTTATGACCTTACAAGAAAAAATGAGCATTTTAAATGAGGTTGGAGTTCACTTAGAAAACT
ATGGAGAGAATACTTTTATTTTGAGAGAACATCCTATTTGGTTACAGGAAAAAGAAATTGAATCAGCCGTTTATGAGATG
TGTGACATGTTGCTGTTGACAAATGAAGTCTCCATTAAGAAATATCGAGCGGAATTAGCTATTATGATGTCTTGCAAGCG
TTCTATCAAGGCTAATCATACTTTGGATGATTATTCTGCCAGAAATCTCTTAATTCAATTATCACAGTGCAAAAATCCTT
ACAATTGTCCTCATGGACGTCCTGTGCTTGTGAATTTCACAAAAGCTGATATGGAAAAGATGTTTCGTCGCATTCAGGAA
AACCATACTAGTTTGAGGGAATTAGGGAAATACTGA

Domains

Predicted by InterProScan.

MutL C terminal dimerisation domain (MutL_C)

(453-595)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-135)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(210-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

69.757

100

0.705

Multiple sequence alignment