Detailed information    

insolico Bioinformatically predicted

Overview

Name   vraR   Type   Regulator
Locus tag   LXA49_RS02195 Genome accession   NZ_CP089949
Coordinates   408077..408709 (+) Length   210 a.a.
NCBI ID   WP_000698434.1    Uniprot ID   Q9S1J7
Organism   Streptococcus pneumoniae strain SN75752     
Function   repress expression of competence genes (predicted from homology)   
Competence regulation

Genomic Context

Location: 403077..413709
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LXA49_RS02170 (LXA49_02165) mvaD 403355..404308 (+) 954 WP_000373458.1 diphosphomevalonate decarboxylase -
  LXA49_RS02175 (LXA49_02170) - 404295..405302 (+) 1008 WP_000562431.1 phosphomevalonate kinase -
  LXA49_RS02180 (LXA49_02175) fni 405286..406296 (+) 1011 WP_000210618.1 type 2 isopentenyl-diphosphate Delta-isomerase -
  LXA49_RS02185 (LXA49_02180) liaF 406373..407071 (+) 699 WP_001224636.1 cell wall-active antibiotics response protein LiaF -
  LXA49_RS02190 (LXA49_02185) - 407068..408063 (+) 996 WP_000743672.1 sensor histidine kinase -
  LXA49_RS02195 (LXA49_02190) vraR 408077..408709 (+) 633 WP_000698434.1 response regulator transcription factor Regulator
  LXA49_RS02200 (LXA49_02195) - 408785..409478 (+) 694 Protein_436 DNA alkylation repair protein -
  LXA49_RS02205 (LXA49_02200) - 409628..409867 (+) 240 WP_061747464.1 hypothetical protein -
  LXA49_RS02210 (LXA49_02205) cbpG 409948..410538 (+) 591 Protein_438 choline-binding protein CbpG -
  LXA49_RS02215 (LXA49_02210) - 410840..411232 (+) 393 WP_000378125.1 tyrosine-type recombinase/integrase -
  LXA49_RS02220 (LXA49_02215) tig 411393..412676 (+) 1284 WP_000116465.1 trigger factor -

Sequence

Protein


Download         Length: 210 a.a.        Molecular weight: 23553.03 Da        Isoelectric Point: 4.5791

>NTDB_id=552773 LXA49_RS02195 WP_000698434.1 408077..408709(+) (vraR) [Streptococcus pneumoniae strain SN75752]
MKILLVDDHEMVRLGLKSYFDLQDDVEVVGEASNGSQGIDLALELRPDVIVMDIVMPEMNGIDATLAILKEWPEAKILIV
TSYLDNEKIMPVLDAGAKGYMLKTSSADELLHAVSKVAAGELAIEQEVSKKVEYHRNHMELHEELTARERDVLQLIAKGY
ENQRIADDLFISLKTVKTHVSNILAKLEVSDRTQAAVYAFQHHLVGQEEF

Nucleotide


Download         Length: 633 bp        

>NTDB_id=552773 LXA49_RS02195 WP_000698434.1 408077..408709(+) (vraR) [Streptococcus pneumoniae strain SN75752]
ATGAAAATTTTACTAGTAGATGACCATGAAATGGTCCGATTGGGCTTGAAAAGCTACTTTGACCTCCAAGACGATGTAGA
AGTTGTGGGTGAGGCGTCCAACGGGTCTCAAGGGATTGACTTGGCCTTGGAACTGCGTCCAGATGTCATTGTCATGGATA
TTGTCATGCCTGAGATGAATGGGATTGACGCGACCTTAGCAATCCTTAAAGAATGGCCTGAAGCCAAGATTTTGATTGTG
ACCTCTTATTTGGACAATGAAAAAATCATGCCAGTCTTAGATGCTGGTGCCAAAGGCTATATGCTCAAGACTTCTAGTGC
AGATGAATTGCTTCATGCCGTCAGTAAGGTAGCTGCTGGCGAGCTGGCCATTGAGCAAGAGGTTAGCAAGAAGGTTGAAT
ACCACCGCAATCATATGGAACTTCATGAAGAATTGACTGCGCGTGAGCGAGATGTTCTCCAACTCATCGCCAAGGGCTAC
GAAAATCAGCGCATCGCAGATGACCTCTTTATCTCTCTCAAGACGGTCAAGACCCACGTGTCCAATATTCTTGCCAAACT
TGAAGTCAGCGATCGTACCCAGGCGGCTGTCTATGCCTTTCAGCACCATTTGGTGGGGCAAGAGGAGTTTTAG

Domains

Predicted by InterProScan.

Bacterial regulatory proteins, luxR family (GerE)

(145-199)

Response regulator receiver domain (Response_reg)

(3-114)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9S1J7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vraR Staphylococcus aureus N315

52.153

99.524

0.519
  degU Bacillus subtilis subsp. subtilis str. 168

38.393

100

0.41