Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   J5Z97_RS06280 Genome accession   NZ_CP072112
Coordinates   1231828..1234110 (+) Length   760 a.a.
NCBI ID   WP_002983882.1    Uniprot ID   A0A6C2WI15
Organism   Streptococcus pyogenes strain M08500     
Function   repress competence development (at the early growth phase) (predicted from homology)   
Competence regulation

Genomic Context

Location: 1226828..1239110
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  J5Z97_RS06255 (J5Z97_06255) - 1227188..1228186 (+) 999 WP_208769250.1 IS30-like element IS1239 family transposase -
  J5Z97_RS06260 (J5Z97_06260) - 1228196..1229605 (-) 1410 WP_023611773.1 deoxyribodipyrimidine photo-lyase -
  J5Z97_RS06265 (J5Z97_06265) - 1229753..1230487 (-) 735 WP_002983889.1 amino acid ABC transporter ATP-binding protein -
  J5Z97_RS06270 (J5Z97_06270) - 1230487..1231173 (-) 687 WP_011054708.1 amino acid ABC transporter permease -
  J5Z97_RS06275 (J5Z97_06275) - 1231300..1231530 (-) 231 WP_002983885.1 YkuJ family protein -
  J5Z97_RS06280 (J5Z97_06280) clpE 1231828..1234110 (+) 2283 WP_002983882.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  J5Z97_RS06285 (J5Z97_06285) - 1234239..1234694 (+) 456 WP_002989103.1 NUDIX domain-containing protein -
  J5Z97_RS06290 (J5Z97_06290) - 1234745..1235047 (+) 303 WP_023611790.1 DUF1827 family protein -
  J5Z97_RS06295 (J5Z97_06295) ileS 1235312..1238113 (-) 2802 WP_208769251.1 isoleucine--tRNA ligase -

Sequence

Protein


Download         Length: 760 a.a.        Molecular weight: 84718.88 Da        Isoelectric Point: 5.0123

>NTDB_id=550486 J5Z97_RS06280 WP_002983882.1 1231828..1234110(+) (clpE) [Streptococcus pyogenes strain M08500]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide


Download         Length: 2283 bp        

>NTDB_id=550486 J5Z97_RS06280 WP_002983882.1 1231828..1234110(+) (clpE) [Streptococcus pyogenes strain M08500]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTGTTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAGCCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCCGCGGTGAATT
GCAGTTGGTCGGCGCTACCACCTTAAATGAATATCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGACCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCCTATTCGTTGGACCGACTGGGGTTGGTAAAACAGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCATAT
TCACTTATTCTCTTAGATGAGGTGGAAAAGGCTCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGACGGTCG
CTTAACAGACGGTCAAGGGCGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAGCATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATCGAAGATGCCATTACA
GACTATTATTTAGAACACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAACATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTAGATTAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(300-397)

ATPase family associated with various cellular activities (AAA) (AAA)

(162-281)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(656-729)

AAA domain (Cdc48 subfamily) (AAA_2)

(485-648)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6C2WI15

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus mutans UA159

84.759

98.421

0.834
  clpE Streptococcus pneumoniae Rx1

82.69

98.816

0.817
  clpE Streptococcus pneumoniae D39

82.69

98.816

0.817
  clpE Streptococcus pneumoniae R6

82.69

98.816

0.817
  clpE Streptococcus pneumoniae TIGR4

82.557

98.816

0.816
  clpC Lactococcus lactis subsp. cremoris KW2

75.164

100

0.753
  clpC Bacillus subtilis subsp. subtilis str. 168

51.593

86.711

0.447
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46

85.526

0.393
  clpC Streptococcus pneumoniae Rx1

47.84

82.237

0.393
  clpC Streptococcus pneumoniae D39

47.84

82.237

0.393
  clpC Streptococcus pneumoniae TIGR4

47.84

82.237

0.393
  clpC Streptococcus mutans UA159

47.573

81.316

0.387
  clpC Streptococcus thermophilus LMD-9

47.115

82.105

0.387
  clpC Streptococcus thermophilus LMG 18311

46.795

82.105

0.384