Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   LTK19_RS12415 Genome accession   NZ_CP089156
Coordinates   2458382..2460163 (+) Length   593 a.a.
NCBI ID   WP_000390514.1    Uniprot ID   Q9ZEH3
Organism   Staphylococcus aureus strain UNC_SaCF35     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2453382..2465163
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  LTK19_RS12395 (LTK19_12395) polX 2453501..2455213 (+) 1713 WP_000161937.1 DNA polymerase/3'-5' exonuclease PolX -
  LTK19_RS12400 (LTK19_12400) mutS/mutS2 2455223..2457571 (+) 2349 WP_001249264.1 endonuclease MutS2 Machinery gene
  LTK19_RS12405 (LTK19_12405) trxA 2457744..2458058 (+) 315 WP_001018928.1 thioredoxin -
  LTK19_RS12410 (LTK19_12410) - 2458121..2458216 (-) 96 WP_001791491.1 hypothetical protein -
  LTK19_RS12415 (LTK19_12415) uvrC 2458382..2460163 (+) 1782 WP_000390514.1 excinuclease ABC subunit UvrC Machinery gene
  LTK19_RS12420 (LTK19_12420) - 2460487..2461101 (+) 615 WP_000079317.1 succinate dehydrogenase cytochrome b558 subunit -
  LTK19_RS12425 (LTK19_12425) sdhA 2461153..2462919 (+) 1767 WP_232043953.1 succinate dehydrogenase flavoprotein subunit -
  LTK19_RS12430 (LTK19_12430) sdhB 2462919..2463734 (+) 816 WP_000139709.1 succinate dehydrogenase iron-sulfur subunit -
  LTK19_RS12435 (LTK19_12435) racE 2463973..2464773 (+) 801 WP_001039660.1 glutamate racemase -

Sequence

Protein


Download         Length: 593 a.a.        Molecular weight: 68644.38 Da        Isoelectric Point: 9.8180

>NTDB_id=549200 LTK19_RS12415 WP_000390514.1 2458382..2460163(+) (uvrC) [Staphylococcus aureus strain UNC_SaCF35]
MEDYKKRIKNKLNVVPMEPGCYLMKDRNDQVIYVGKAKKLRNRLRSYFTGAHDAKTTRLVGEIRRFEFIVTSSETESLLL
ELNLIKQYQPRYNILLKDDKSYPFIKITKEKYPRLLVTRTVKQGTGKYFGPYPNAYSAQETKKLLDRIYPYRKCDKMPDK
LCLYYHIGQCLGPCVYDVDLSKYAQMTKEITDFLNGEDKTILKSLEERMLTASESLDFERAKEYRDLIQHIQNLTNKQKI
MSSDKTIRDVFGYSVDKGWMCIQVFFIRQGNMIKRDTTMIPLQQTEEEEFYTFIGQFYSLNQHILPKEVHVPRNLDKEMI
QSVVDTKIVQPARGPKKDMVDLAAHNAKVSLNNKFELISRDESRTIKAIEELGTQMGIQTPIRIEAFDNSNIQGVDPVSA
MVTFVDGKPDKKNYRKYKIKTVKGPDDYKSMREVVRRRYSRVLNEGLPLPDLIIVDGGKGHMNGVIDVLQNELGLDIPVA
GLQKNDKHQTSELLYGASAEIVPLKKNSQAFYLLHRIQDEVHRFAITFHRQTRQKTGLKSILDDIDGIGSKRKTLLLRSF
GSIKKMKEATLEDFKNIGIPENVAKNLHEQLHK

Nucleotide


Download         Length: 1782 bp        

>NTDB_id=549200 LTK19_RS12415 WP_000390514.1 2458382..2460163(+) (uvrC) [Staphylococcus aureus strain UNC_SaCF35]
TTGGAAGACTATAAGAAACGAATTAAAAATAAATTAAATGTCGTACCTATGGAACCAGGCTGCTATTTAATGAAAGATCG
TAACGATCAAGTGATATATGTTGGCAAAGCTAAAAAGCTAAGAAATCGATTGCGATCATATTTTACGGGCGCTCATGATG
CTAAAACAACGAGACTGGTTGGTGAAATACGTCGCTTTGAGTTTATTGTCACGTCTAGTGAAACAGAGTCACTTTTACTT
GAATTAAATCTGATTAAACAATATCAACCAAGATATAATATATTATTAAAGGATGATAAAAGTTATCCATTTATTAAAAT
TACGAAGGAAAAATATCCTAGACTACTAGTGACGAGAACTGTAAAACAAGGTACTGGTAAATATTTCGGACCGTATCCGA
ATGCATATTCTGCTCAAGAAACTAAAAAGTTATTAGACAGAATATATCCATATCGCAAATGTGATAAGATGCCAGATAAA
TTATGTCTTTATTACCATATTGGACAATGTTTAGGACCATGTGTATATGACGTTGATTTGAGTAAATACGCACAAATGAC
GAAGGAAATTACTGATTTTCTGAATGGGGAAGACAAAACAATTTTAAAAAGTTTAGAAGAGAGAATGTTAACTGCAAGTG
AATCACTTGATTTTGAACGAGCTAAAGAATACAGAGATTTAATTCAACATATTCAAAATCTAACTAACAAACAAAAAATT
ATGTCATCAGATAAAACGATTCGTGATGTCTTTGGTTATAGTGTTGATAAAGGATGGATGTGTATCCAAGTTTTCTTTAT
AAGACAAGGTAATATGATAAAGCGAGATACAACGATGATTCCATTACAGCAAACAGAAGAAGAAGAATTTTATACATTTA
TTGGACAATTTTATAGCTTAAACCAACATATTTTACCTAAGGAAGTTCATGTACCACGTAATTTGGATAAAGAAATGATT
CAATCTGTTGTGGACACTAAAATCGTTCAACCCGCGCGAGGTCCCAAAAAAGATATGGTTGACTTAGCTGCACATAACGC
TAAAGTATCCTTAAATAATAAATTTGAATTAATATCACGTGATGAGTCCAGAACAATTAAAGCTATTGAAGAACTTGGAA
CACAAATGGGAATTCAAACACCAATTAGAATTGAAGCATTCGATAATTCTAATATTCAAGGTGTGGATCCAGTGTCAGCA
ATGGTTACATTTGTCGACGGTAAACCAGACAAGAAAAATTATAGAAAGTATAAAATCAAAACGGTTAAAGGTCCAGATGA
TTACAAATCAATGAGAGAAGTAGTAAGACGACGATATTCTCGCGTTTTAAACGAAGGATTACCATTACCTGATTTAATAA
TAGTAGATGGTGGTAAAGGACATATGAACGGGGTTATTGATGTGCTACAAAACGAATTAGGTCTTGATATCCCTGTTGCA
GGTTTGCAGAAAAATGATAAACACCAAACATCTGAATTATTATATGGCGCTAGTGCAGAAATTGTACCACTGAAGAAAAA
TAGCCAAGCATTTTATTTGTTGCACCGTATCCAAGATGAGGTTCACAGATTCGCAATCACATTTCATAGACAAACACGTC
AAAAGACAGGCTTGAAATCAATCCTTGATGATATAGATGGTATCGGTAGCAAACGTAAAACATTATTATTGCGTTCATTC
GGTTCAATCAAGAAAATGAAGGAAGCTACACTTGAAGATTTTAAAAATATAGGTATTCCTGAAAACGTTGCAAAGAACCT
ACATGAACAATTGCATAAATAA

Domains

Predicted by InterProScan.

UvrB/uvrC motif (UVR)

(200-233)

GIY-YIG catalytic domain (GIY-YIG)

(19-93)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(379-526)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9ZEH3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Streptococcus pneumoniae TIGR4

57.436

98.651

0.567
  uvrC Streptococcus pneumoniae R6

57.436

98.651

0.567
  uvrC Streptococcus pneumoniae D39

57.436

98.651

0.567