Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | J4Q31_RS09490 | Genome accession | NZ_CP071918 |
| Coordinates | 1823083..1823703 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain 19A-19343 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1811538..1855444 | 1823083..1823703 | within | 0 |
Gene organization within MGE regions
Location: 1811538..1855444
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4Q31_RS09425 (J4Q31_09430) | - | 1811835..1812386 (-) | 552 | WP_233923012.1 | hypothetical protein | - |
| J4Q31_RS09430 (J4Q31_09435) | - | 1812376..1813371 (-) | 996 | WP_233922961.1 | hypothetical protein | - |
| J4Q31_RS09435 (J4Q31_09440) | - | 1813779..1814204 (-) | 426 | WP_233922962.1 | hypothetical protein | - |
| J4Q31_RS09440 (J4Q31_09445) | - | 1814333..1814692 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| J4Q31_RS09445 (J4Q31_09450) | - | 1814738..1814944 (-) | 207 | WP_000366088.1 | hypothetical protein | - |
| J4Q31_RS09450 (J4Q31_09455) | - | 1814931..1815092 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| J4Q31_RS09455 (J4Q31_09460) | lytA | 1815451..1816407 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| J4Q31_RS09460 (J4Q31_09465) | - | 1816783..1818153 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| J4Q31_RS09465 (J4Q31_09470) | recA | 1818460..1819626 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| J4Q31_RS09470 (J4Q31_09475) | cinA | 1819681..1820937 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| J4Q31_RS09475 (J4Q31_09480) | brpA | 1821022..1822038 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| J4Q31_RS09480 (J4Q31_09485) | - | 1822046..1822564 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| J4Q31_RS09485 (J4Q31_09490) | tsaE | 1822554..1822997 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| J4Q31_RS09490 (J4Q31_09495) | comM | 1823083..1823703 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| J4Q31_RS09495 (J4Q31_09500) | - | 1824009..1824872 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| J4Q31_RS11610 | - | 1825051..1825221 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| J4Q31_RS09500 (J4Q31_09505) | - | 1825623..1825937 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| J4Q31_RS09505 (J4Q31_09510) | - | 1825953..1826339 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| J4Q31_RS09510 (J4Q31_09515) | - | 1826368..1827753 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| J4Q31_RS09515 (J4Q31_09520) | - | 1827756..1827908 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| J4Q31_RS09520 (J4Q31_09525) | mobT | 1827931..1829193 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| J4Q31_RS09525 (J4Q31_09530) | - | 1829138..1829350 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| J4Q31_RS09530 (J4Q31_09535) | - | 1829399..1829482 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| J4Q31_RS09535 (J4Q31_09540) | erm(B) | 1829607..1830344 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| J4Q31_RS09540 (J4Q31_09545) | - | 1830601..1831848 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| J4Q31_RS09545 (J4Q31_09550) | - | 1832028..1832249 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| J4Q31_RS09550 (J4Q31_09555) | - | 1832366..1832863 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| J4Q31_RS09555 (J4Q31_09560) | - | 1832952..1833344 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| J4Q31_RS09560 (J4Q31_09565) | - | 1833328..1835775 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| J4Q31_RS09565 (J4Q31_09570) | - | 1835778..1837955 (+) | 2178 | WP_000804748.1 | CD3337/EF1877 family mobilome membrane protein | - |
| J4Q31_RS09570 (J4Q31_09575) | - | 1837952..1838953 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| J4Q31_RS09575 (J4Q31_09580) | - | 1838950..1839882 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| J4Q31_RS11860 | - | 1840196..1840243 (+) | 48 | Protein_1899 | hypothetical protein | - |
| J4Q31_RS09585 (J4Q31_09590) | tet(M) | 1840259..1842178 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| J4Q31_RS09590 (J4Q31_09595) | - | 1842542..1842787 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| J4Q31_RS09595 (J4Q31_09600) | - | 1842784..1843119 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| J4Q31_RS09600 (J4Q31_09605) | - | 1843132..1843500 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| J4Q31_RS09605 (J4Q31_09610) | - | 1843487..1843786 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| J4Q31_RS09610 (J4Q31_09615) | msr(D) | 1843904..1845367 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| J4Q31_RS09615 (J4Q31_09620) | mef(A) | 1845487..1846704 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| J4Q31_RS09620 (J4Q31_09625) | - | 1847090..1847260 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| J4Q31_RS09625 (J4Q31_09630) | - | 1847782..1847973 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| J4Q31_RS09630 (J4Q31_09635) | - | 1848033..1848386 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| J4Q31_RS09635 (J4Q31_09640) | - | 1848891..1849313 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| J4Q31_RS09640 (J4Q31_09645) | - | 1849310..1849540 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| J4Q31_RS09645 | - | 1849766..1850017 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| J4Q31_RS09650 (J4Q31_09650) | - | 1850001..1850204 (+) | 204 | WP_000814511.1 | excisionase | - |
| J4Q31_RS09655 (J4Q31_09655) | - | 1850286..1851503 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| J4Q31_RS09660 (J4Q31_09660) | - | 1852394..1854409 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| J4Q31_RS09665 (J4Q31_09665) | - | 1854411..1855043 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=549129 J4Q31_RS09490 WP_000839909.1 1823083..1823703(-) (comM) [Streptococcus pneumoniae strain 19A-19343]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=549129 J4Q31_RS09490 WP_000839909.1 1823083..1823703(-) (comM) [Streptococcus pneumoniae strain 19A-19343]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |