Detailed information
Bioinformatically predicted
Overview
| Name | comM | Type | Regulator |
| Locus tag | J4Q32_RS09230 | Genome accession | NZ_CP071916 |
| Coordinates | 1786359..1786979 (-) | Length | 206 a.a. |
| NCBI ID | WP_000839909.1 | Uniprot ID | A0A098Z2X2 |
| Organism | Streptococcus pneumoniae strain 19A-19087 | ||
| Function | fratricide immunity (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1774814..1818733 | 1786359..1786979 | within | 0 |
Gene organization within MGE regions
Location: 1774814..1818733
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| J4Q32_RS09165 (J4Q32_09165) | - | 1775111..1775662 (-) | 552 | WP_233923012.1 | hypothetical protein | - |
| J4Q32_RS09170 (J4Q32_09170) | - | 1775652..1776647 (-) | 996 | WP_233922961.1 | hypothetical protein | - |
| J4Q32_RS09175 (J4Q32_09175) | - | 1777055..1777480 (-) | 426 | WP_233922962.1 | hypothetical protein | - |
| J4Q32_RS09180 (J4Q32_09180) | - | 1777609..1777968 (-) | 360 | WP_000749821.1 | ImmA/IrrE family metallo-endopeptidase | - |
| J4Q32_RS09185 (J4Q32_09185) | - | 1778014..1778220 (-) | 207 | WP_000366088.1 | hypothetical protein | - |
| J4Q32_RS09190 (J4Q32_09190) | - | 1778207..1778368 (-) | 162 | WP_000289348.1 | helix-turn-helix domain-containing protein | - |
| J4Q32_RS09195 (J4Q32_09195) | lytA | 1778727..1779683 (-) | 957 | WP_000405240.1 | N-acetylmuramoyl-L-alanine amidase LytA | - |
| J4Q32_RS09200 (J4Q32_09200) | - | 1780059..1781429 (-) | 1371 | WP_001036271.1 | MATE family efflux transporter | - |
| J4Q32_RS09205 (J4Q32_09205) | recA | 1781736..1782902 (-) | 1167 | WP_001085462.1 | recombinase RecA | Machinery gene |
| J4Q32_RS09210 (J4Q32_09210) | cinA | 1782957..1784213 (-) | 1257 | WP_000642704.1 | competence/damage-inducible protein A | Machinery gene |
| J4Q32_RS09215 (J4Q32_09215) | brpA | 1784298..1785314 (-) | 1017 | WP_000239278.1 | biofilm formation/cell division transcriptional regulator BrpA | - |
| J4Q32_RS09220 (J4Q32_09220) | - | 1785322..1785840 (-) | 519 | WP_000455536.1 | GNAT family N-acetyltransferase | - |
| J4Q32_RS09225 (J4Q32_09225) | tsaE | 1785830..1786273 (-) | 444 | WP_000288230.1 | tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE | - |
| J4Q32_RS09230 (J4Q32_09230) | comM | 1786359..1786979 (-) | 621 | WP_000839909.1 | hypothetical protein | Regulator |
| J4Q32_RS09235 (J4Q32_09235) | - | 1787285..1788148 (-) | 864 | WP_001093609.1 | helix-turn-helix domain-containing protein | - |
| J4Q32_RS11350 | - | 1788340..1788510 (+) | 171 | WP_001227863.1 | PhrA family quorum-sensing system peptide | - |
| J4Q32_RS09240 (J4Q32_09240) | - | 1788912..1789226 (+) | 315 | WP_000420682.1 | YdcP family protein | - |
| J4Q32_RS09245 (J4Q32_09245) | - | 1789242..1789628 (+) | 387 | WP_000985015.1 | YdcP family protein | - |
| J4Q32_RS09250 (J4Q32_09250) | - | 1789657..1791042 (+) | 1386 | WP_000813494.1 | FtsK/SpoIIIE domain-containing protein | - |
| J4Q32_RS09255 (J4Q32_09255) | - | 1791045..1791197 (+) | 153 | WP_000879507.1 | hypothetical protein | - |
| J4Q32_RS09260 (J4Q32_09260) | mobT | 1791220..1792482 (+) | 1263 | WP_001814870.1 | MobT family relaxase | - |
| J4Q32_RS09265 (J4Q32_09265) | - | 1792427..1792639 (+) | 213 | WP_029645760.1 | peptide-binding protein | - |
| J4Q32_RS09270 (J4Q32_09270) | - | 1792688..1792771 (+) | 84 | WP_001814874.1 | 23S rRNA methyltransferase attenuation leader peptide | - |
| J4Q32_RS09275 (J4Q32_09275) | erm(B) | 1792896..1793633 (+) | 738 | WP_001038795.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(B) | - |
| J4Q32_RS09280 (J4Q32_09280) | - | 1793890..1795137 (-) | 1248 | WP_000019067.1 | ISL3 family transposase | - |
| J4Q32_RS09285 (J4Q32_09285) | - | 1795317..1795538 (+) | 222 | WP_001009056.1 | hypothetical protein | - |
| J4Q32_RS09290 (J4Q32_09290) | - | 1795655..1796152 (+) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| J4Q32_RS09295 (J4Q32_09295) | - | 1796241..1796633 (+) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| J4Q32_RS09300 (J4Q32_09300) | - | 1796617..1799064 (+) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| J4Q32_RS09305 (J4Q32_09305) | - | 1799067..1801244 (+) | 2178 | WP_000804748.1 | CD3337/EF1877 family mobilome membrane protein | - |
| J4Q32_RS09310 (J4Q32_09310) | - | 1801241..1802242 (+) | 1002 | WP_000769868.1 | lysozyme family protein | - |
| J4Q32_RS09315 (J4Q32_09315) | - | 1802239..1803171 (+) | 933 | WP_001224318.1 | conjugal transfer protein | - |
| J4Q32_RS11600 | - | 1803485..1803532 (+) | 48 | Protein_1846 | hypothetical protein | - |
| J4Q32_RS09325 (J4Q32_09325) | tet(M) | 1803548..1805467 (+) | 1920 | WP_000691729.1 | tetracycline resistance ribosomal protection protein Tet(M) | - |
| J4Q32_RS09330 (J4Q32_09330) | - | 1805831..1806076 (+) | 246 | WP_001813542.1 | hypothetical protein | - |
| J4Q32_RS09335 (J4Q32_09335) | - | 1806073..1806408 (+) | 336 | WP_000806926.1 | hypothetical protein | - |
| J4Q32_RS09340 (J4Q32_09340) | - | 1806421..1806789 (+) | 369 | WP_000567222.1 | hypothetical protein | - |
| J4Q32_RS09345 (J4Q32_09345) | - | 1806776..1807075 (+) | 300 | WP_001072467.1 | DUF5960 family protein | - |
| J4Q32_RS09350 (J4Q32_09350) | msr(D) | 1807193..1808656 (-) | 1464 | WP_000420313.1 | ABC-F type ribosomal protection protein Msr(D) | - |
| J4Q32_RS09355 (J4Q32_09355) | mef(A) | 1808776..1809993 (-) | 1218 | WP_000417519.1 | macrolide efflux MFS transporter Mef(A) | - |
| J4Q32_RS09360 (J4Q32_09360) | - | 1810379..1810549 (-) | 171 | WP_000873143.1 | hypothetical protein | - |
| J4Q32_RS09365 (J4Q32_09365) | - | 1811071..1811262 (+) | 192 | WP_001860868.1 | cysteine-rich KTR domain-containing protein | - |
| J4Q32_RS09370 (J4Q32_09370) | - | 1811322..1811675 (-) | 354 | WP_001227347.1 | helix-turn-helix transcriptional regulator | - |
| J4Q32_RS09375 (J4Q32_09375) | - | 1812180..1812602 (+) | 423 | WP_000804885.1 | sigma-70 family RNA polymerase sigma factor | - |
| J4Q32_RS09380 (J4Q32_09380) | - | 1812599..1812829 (+) | 231 | WP_000857133.1 | helix-turn-helix domain-containing protein | - |
| J4Q32_RS09385 | - | 1813055..1813306 (-) | 252 | WP_001845478.1 | hypothetical protein | - |
| J4Q32_RS09390 (J4Q32_09385) | - | 1813290..1813493 (+) | 204 | WP_000814511.1 | excisionase | - |
| J4Q32_RS09395 (J4Q32_09390) | - | 1813575..1814792 (+) | 1218 | WP_001291561.1 | tyrosine-type recombinase/integrase | - |
| J4Q32_RS09400 (J4Q32_09395) | - | 1815683..1817698 (+) | 2016 | WP_000732395.1 | DUF1430 domain-containing protein | - |
| J4Q32_RS09405 (J4Q32_09400) | - | 1817700..1818332 (+) | 633 | WP_000571425.1 | ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 206 a.a. Molecular weight: 23540.66 Da Isoelectric Point: 10.1254
>NTDB_id=548969 J4Q32_RS09230 WP_000839909.1 1786359..1786979(-) (comM) [Streptococcus pneumoniae strain 19A-19087]
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
MKSMRILFLLALIQISLSSCFLWKECILSFKQSTAFFIGSMVFVSGICAGVNYLYTRKQEVHSVLASKKSVKLFYSMLLL
INLLGAVLVLSDNLFIKNTLQQELVDFLLPSFFFLFGLDLLIFLPLKKYVRDFLAMLDRKKTVLVTILATLLFLRNPMTI
VSLLIYTGLGLFFAAYLVPNSVKKEVSFYGHIFRDLVLVIVTLIFF
Nucleotide
Download Length: 621 bp
>NTDB_id=548969 J4Q32_RS09230 WP_000839909.1 1786359..1786979(-) (comM) [Streptococcus pneumoniae strain 19A-19087]
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
ATGAAATCAATGAGAATCTTATTTTTGTTAGCTTTAATTCAAATCAGTTTGAGTAGCTGTTTCCTATGGAAGGAATGCAT
CTTGTCCTTTAAACAAAGTACAGCTTTTTTCATCGGAAGCATGGTTTTCGTTTCAGGAATCTGTGCTGGAGTAAATTATC
TTTATACCCGTAAGCAAGAAGTCCATAGTGTCCTAGCCAGTAAGAAGTCGGTGAAGCTTTTTTACAGTATGTTACTCTTA
ATTAATTTGTTAGGAGCTGTTCTTGTTTTGTCAGATAACTTGTTCATCAAAAATACGCTGCAGCAAGAATTAGTTGACTT
TTTATTGCCATCCTTCTTTTTCCTATTTGGGCTAGATTTGCTGATTTTTTTACCCTTGAAAAAATACGTGCGCGATTTTC
TTGCTATGCTAGACAGAAAAAAGACAGTGTTGGTGACTATTTTAGCAACACTTCTTTTCTTAAGAAATCCAATGACCATT
GTCTCACTTCTGATTTATACTGGACTGGGCTTGTTTTTTGCAGCCTATCTTGTCCCAAATTCGGTTAAGAAGGAAGTTTC
CTTTTATGGTCATATTTTCCGAGATCTTGTATTGGTCATTGTTACGCTCATTTTCTTTTAG
Domains
No domain identified.
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comM | Streptococcus pneumoniae D39 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae R6 |
99.515 |
100 |
0.995 |
| comM | Streptococcus pneumoniae TIGR4 |
99.515 |
100 |
0.995 |
| comM | Streptococcus mitis NCTC 12261 |
38.462 |
94.66 |
0.364 |
| comM | Streptococcus mitis SK321 |
38.462 |
94.66 |
0.364 |