Detailed information NTG0541954

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: JYA46_RS00510
• Genome accession: NZ_CP070991
• Coordinates: 91559..92602 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain CBS2016-05
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86559..97602

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
JYA46_RS00480 (JYA46_000096)	-	87290..87401 (+)	112	Protein_96	hypothetical protein	-
JYA46_RS00485 (JYA46_000097)	-	87430..87843 (+)	414	WP_072491843.1	hypothetical protein	-
JYA46_RS00490 (JYA46_000098)	-	88032..89018 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
JYA46_RS00495 (JYA46_000099)	map	89485..90243 (+)	759	WP_061732059.1	type I methionyl aminopeptidase	-
JYA46_RS00500 (JYA46_000100)	-	90460..90846 (+)	387	WP_210994220.1	hypothetical protein	-
JYA46_RS00505 (JYA46_000101)	liaF	90861..91562 (+)	702	WP_098818122.1	cell wall-active antibiotics response protein LiaF	-
JYA46_RS00510 (JYA46_000102)	vraS	91559..92602 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
JYA46_RS00515 (JYA46_000103)	vraR	92592..93221 (+)	630	WP_072491830.1	two-component system response regulator VraR	Regulator
JYA46_RS00520 (JYA46_000104)	-	93334..94551 (-)	1218	WP_210994221.1	YihY/virulence factor BrkB family protein	-
JYA46_RS00525 (JYA46_000105)	-	94829..95104 (-)	276	WP_072491832.1	YtxH domain-containing protein	-
JYA46_RS00530 (JYA46_000106)	-	95111..95575 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
JYA46_RS00535 (JYA46_000107)	-	95722..95922 (+)	201	WP_000180460.1	DUF1128 family protein	-
JYA46_RS00540 (JYA46_000108)	-	95925..97181 (+)	1257	WP_001793428.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=541954 JYA46_RS00510 WP_001017131.1 91559..92602(+) (vraS) [Staphylococcus aureus strain CBS2016-05]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=541954 JYA46_RS00510 WP_001017131.1 91559..92602(+) (vraS) [Staphylococcus aureus strain CBS2016-05]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1