Detailed information NTG0054192

Bioinformatically predicted

Overview

• Name: clpX
• Type: Regulator
• Locus tag: A20_RS03500
• Genome accession: NC_018936
• Coordinates: 691694..692923 (+)
• Length: 409 a.a.
• NCBI ID: WP_002984948.1
• Uniprot ID: A0A4U7GJW1
• Organism: Streptococcus pyogenes A20
• Function: require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 686694..697923

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
A20_RS03475 (A20_0727c)	-	687310..688587 (-)	1278	WP_010922170.1	hydroxymethylglutaryl-CoA reductase, degradative	-
A20_RS03480 (A20_0728c)	-	688574..689749 (-)	1176	WP_010922171.1	hydroxymethylglutaryl-CoA synthase	-
A20_RS03485 (A20_0729)	-	689958..690797 (+)	840	WP_010922172.1	thymidylate synthase	-
A20_RS03490 (A20_0730)	-	690877..691374 (+)	498	WP_011285487.1	dihydrofolate reductase	-
A20_RS09385 (A20_0731)	-	691394..691564 (+)	171	WP_002984950.1	hypothetical protein	-
A20_RS03500 (A20_0732)	clpX	691694..692923 (+)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
A20_RS03505 (A20_0733)	yihA	692933..693532 (+)	600	WP_002984945.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
A20_RS03510 (A20_0734)	-	693680..694423 (+)	744	WP_002984942.1	hypothetical protein	-
A20_RS03515 (A20_0735c)	-	694481..696580 (-)	2100	WP_010922175.1	AAA family ATPase	-
A20_RS03520 (A20_0736)	rpiA	696959..697642 (+)	684	WP_010922176.1	ribose-5-phosphate isomerase RpiA	-

Sequence

Protein

• Length: 409 a.a.
• Molecular weight: 44991.44 Da
• Isoelectric Point: 4.5775

>NTDB_id=54192 A20_RS03500 WP_002984948.1 691694..692923(+) (clpX) [Streptococcus pyogenes A20]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIQI
LTEPRNALVKQYQALLSYDGVELAFDKEALEAIANKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide

• Length: 1230 bp

>NTDB_id=54192 A20_RS03500 WP_002984948.1 691694..692923(+) (clpX) [Streptococcus pyogenes A20]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCCAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATCGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCAAATT
TTGACAGAACCAAGAAATGCCCTGGTCAAGCAATATCAGGCTCTTCTTTCTTACGATGGCGTCGAATTGGCATTTGATAA
GGAAGCCTTAGAAGCCATTGCCAATAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (110-305)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (312-391)

• ClpX C4-type zinc finger (zf-C4_ClpX) (12-48)

3D structure

• AlphaFold DB: A0A4U7GJW1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpX	Streptococcus mutans UA159	88.998	100	0.89
clpX	Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819	58.603	98.044	0.575