Detailed information    

insolico Bioinformatically predicted

Overview

Name   comFA/cflA   Type   Machinery gene
Locus tag   GGS_RS08000 Genome accession   NC_018712
Coordinates   1636965..1638290 (-) Length   441 a.a.
NCBI ID   WP_015017291.1    Uniprot ID   A0A9X8T4I6
Organism   Streptococcus dysgalactiae subsp. equisimilis RE378     
Function   ssDNA transport into the cell (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1631965..1643290
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  GGS_RS07960 (GGS_1511) - 1632337..1632636 (-) 300 WP_000129105.1 hypothetical protein -
  GGS_RS07965 - 1633019..1633216 (-) 198 WP_000208122.1 helix-turn-helix transcriptional regulator -
  GGS_RS07970 - 1633213..1633398 (-) 186 WP_000938679.1 hypothetical protein -
  GGS_RS07975 (GGS_1512) - 1633400..1634425 (-) 1026 WP_000822468.1 replication initiator protein A -
  GGS_RS11035 - 1634427..1634591 (-) 165 WP_000166480.1 hypothetical protein -
  GGS_RS07980 (GGS_1513) - 1634698..1635141 (-) 444 WP_000447421.1 hypothetical protein -
  GGS_RS07985 - 1635407..1635664 (-) 258 WP_000191926.1 DUF3850 domain-containing protein -
  GGS_RS07990 (GGS_1514) - 1635848..1636219 (-) 372 WP_001282475.1 hypothetical protein -
  GGS_RS11340 (GGS_1515) - 1636328..1636993 (-) 666 WP_012767419.1 ComF family protein -
  GGS_RS08000 (GGS_1516) comFA/cflA 1636965..1638290 (-) 1326 WP_015017291.1 DEAD/DEAH box helicase Machinery gene
  GGS_RS08005 (GGS_1517) - 1638346..1638984 (+) 639 WP_015017292.1 YigZ family protein -
  GGS_RS08010 (GGS_1518) cysK 1639088..1640023 (+) 936 WP_003062335.1 cysteine synthase A -
  GGS_RS08015 (GGS_1519) - 1640175..1640534 (-) 360 WP_015017293.1 S1 RNA-binding domain-containing protein -
  GGS_RS08020 (GGS_1520) - 1640534..1641934 (-) 1401 WP_042357970.1 bifunctional Cof-type HAD-IIB family hydrolase/peptidylprolyl isomerase -
  GGS_RS08025 (GGS_1521) - 1641971..1642612 (-) 642 WP_014612503.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 49283.45 Da        Isoelectric Point: 9.7069

>NTDB_id=53970 GGS_RS08000 WP_015017291.1 1636965..1638290(-) (comFA/cflA) [Streptococcus dysgalactiae subsp. equisimilis RE378]
MEGIENSYGRLFLKHQLPKEVNHLAKTLESIVAIKGKVTCQRCHYQITAEARLPSGTYYCRFCLVFGRNQADRPLYYIPP
HPFPIANYLQWKGILTPYQESISNQLVKNVHAKKPTLVHAVTGAGKTEMIYGAIAAVVNAGGWVCLASPRVDVCIELANR
LKAAFSCRVTLLHADSEAYQRSPIIVATTHQLLTFYKAFDLLIIDEVDAFPFVNNHQLQYAAQQAAKEGASSIVLTATST
KELEEQVKSGELEKLTLARRFHDNPLILPKFIRSFGLLKKIHCQKLPRALVKSISQQRKTGCPLLIFLPIIAMAELVTEL
LKLAFPEEQIACVSSQSADRVKDIDAFRQGKKGILVTTTILERGVTFPGVDVFVLMAQHRGYSSQSLVQIAGRVGRSIER
PTGKVYFFHDGISQAMRNARKEIKEMNQKGYLNDMPPMSTI

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=53970 GGS_RS08000 WP_015017291.1 1636965..1638290(-) (comFA/cflA) [Streptococcus dysgalactiae subsp. equisimilis RE378]
ATGGAAGGTATCGAAAACAGTTACGGTCGTTTATTTTTAAAACATCAATTGCCAAAAGAAGTAAATCATCTGGCAAAGAC
CTTGGAAAGTATAGTAGCCATAAAAGGTAAAGTCACTTGTCAACGCTGTCATTATCAGATAACCGCAGAAGCGAGATTAC
CAAGTGGCACTTACTACTGCCGCTTCTGTCTCGTTTTTGGCCGAAATCAAGCTGATAGGCCTCTTTATTATATACCTCCA
CATCCTTTTCCTATAGCCAATTATCTTCAATGGAAGGGGATATTAACGCCCTACCAAGAAAGTATTTCAAACCAATTAGT
CAAGAATGTTCATGCTAAAAAACCTACTTTAGTGCATGCTGTTACCGGAGCCGGCAAGACAGAGATGATTTATGGAGCCA
TAGCAGCAGTTGTTAATGCTGGAGGTTGGGTTTGTTTAGCCAGCCCAAGGGTCGATGTTTGTATAGAACTTGCTAATCGC
TTAAAAGCTGCTTTTTCTTGCCGGGTTACTCTTTTACATGCTGACTCAGAAGCTTATCAAAGAAGTCCTATTATAGTAGC
TACTACCCATCAATTACTGACCTTTTATAAGGCTTTTGATCTTTTAATCATTGATGAAGTTGATGCTTTTCCTTTTGTCA
ATAATCATCAACTACAATATGCAGCGCAGCAAGCCGCTAAAGAAGGCGCTAGTAGTATCGTATTGACCGCGACATCGACC
AAAGAACTGGAAGAGCAGGTCAAAAGTGGGGAACTAGAGAAGTTGACATTAGCTAGACGATTCCACGATAATCCTTTGAT
TCTTCCGAAATTTATCAGGAGTTTTGGTCTATTAAAAAAAATTCACTGTCAAAAACTTCCTCGAGCTCTTGTTAAATCTA
TCAGTCAACAAAGGAAAACAGGATGTCCACTGCTAATTTTCCTTCCTATTATTGCCATGGCAGAATTAGTTACTGAATTA
TTAAAGTTAGCTTTTCCAGAGGAACAAATTGCCTGTGTCTCTAGCCAATCAGCTGACAGAGTTAAAGACATTGATGCCTT
TCGTCAAGGAAAGAAAGGTATTTTGGTGACCACCACAATATTGGAAAGGGGTGTTACTTTCCCAGGCGTGGATGTCTTTG
TGCTTATGGCACAGCATCGAGGATACAGTTCTCAAAGCTTGGTTCAAATCGCAGGTCGTGTGGGGAGATCTATCGAAAGG
CCAACAGGGAAGGTGTATTTCTTTCACGATGGGATTAGCCAAGCAATGCGCAATGCAAGAAAAGAAATTAAAGAAATGAA
TCAGAAAGGTTATTTGAATGATATGCCTCCTATGTCAACAATTTAG

Domains

Predicted by InterproScan.

Helicase conserved C-terminal domain (Helicase_C)

(289-396)

DEAD/DEAH box helicase (DEAD)

(99-244)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comFA/cflA Streptococcus pneumoniae Rx1

53.302

96.145

0.512
  comFA/cflA Streptococcus pneumoniae D39

53.302

96.145

0.512
  comFA/cflA Streptococcus pneumoniae R6

53.302

96.145

0.512
  comFA/cflA Streptococcus pneumoniae TIGR4

53.302

96.145

0.512
  comFA/cflA Streptococcus mitis NCTC 12261

51.852

97.959

0.508
  comFA/cflA Streptococcus mitis SK321

52.214

97.279

0.508
  comFA Lactococcus lactis subsp. cremoris KW2

46.465

89.796

0.417
  comFA Latilactobacillus sakei subsp. sakei 23K

37.587

97.732

0.367

Multiple sequence alignment