NTDB

Overview

Name	clpC	Type	Regulator
Locus tag	LGS58_RS18775	Genome accession	NZ_CP084683
Coordinates	3892896..3895469 (+)	Length	857 a.a.
NCBI ID	WP_001235102.1	Uniprot ID	P63286
Organism	Escherichia coli strain BL21(RP)
Function	degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 3887896..3900469

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LGS58_RS18745 (LGS58_18745)	pheA	3888165..3889325 (-)	1161	WP_000200120.1	bifunctional chorismate mutase/prephenate dehydratase	-
LGS58_RS18750 (LGS58_18750)	pheL	3889423..3889470 (-)	48	WP_001386991.1	pheA operon leader peptide PheL	-
LGS58_RS18755 (LGS58_18755)	raiA	3889574..3889915 (-)	342	WP_000178456.1	ribosome-associated translation inhibitor RaiA	-
LGS58_RS18760 (LGS58_18760)	comL	3890186..3890923 (-)	738	WP_000197686.1	outer membrane protein assembly factor BamD	Machinery gene
LGS58_RS18765 (LGS58_18765)	rluD	3891058..3892038 (+)	981	WP_000079100.1	23S rRNA pseudouridine(1911/1915/1917) synthase RluD	-
LGS58_RS18770 (LGS58_18770)	yfiH	3892035..3892766 (+)	732	WP_000040127.1	purine nucleoside phosphorylase YfiH	-
LGS58_RS18775 (LGS58_18775)	clpC	3892896..3895469 (+)	2574	WP_001235102.1	ATP-dependent chaperone ClpB	Regulator
LGS58_RS18780 (LGS58_18780)	yjdN	3895800..3896243 (+)	444	WP_001131339.1	VOC family metalloprotein YjdN	-
LGS58_RS18785 (LGS58_18785)	phnC	3896376..3897164 (+)	789	WP_001193397.1	phosphonate ABC transporter ATP-binding protein	-
LGS58_RS18790 (LGS58_18790)	phnD	3897189..3898205 (+)	1017	WP_000992000.1	phosphonate ABC transporter substrate-binding protein	-
LGS58_RS18795 (LGS58_18795)	phnE	3898311..3899090 (+)	780	WP_001193500.1	phosphonate ABC transporter, permease protein PhnE	-
LGS58_RS18800 (LGS58_18800)	phnF	3899111..3899836 (+)	726	WP_001295387.1	phosphonate metabolism transcriptional regulator PhnF	-
LGS58_RS18805 (LGS58_18805)	phnG	3899837..3900289 (+)	453	WP_000542785.1	phosphonate C-P lyase system protein PhnG	-

Sequence

Protein

Download Length: 857 a.a. Molecular weight: 95585.02 Da Isoelectric Point: 5.1899

                                >NTDB_id=535155 LGS58_RS18775 WP_001235102.1 3892896..3895469(+) (clpC) [Escherichia coli strain BL21(RP)]

MRLDRLTNKFQLALADAQSLALGHDNQFIEPLHLMSALLNQEGGSVSPLLTSAGINAGQLRTDINQALNRLPQVEGTGGD

VQPSQDLVRVLNLCDKLAQKRGDNFISSELFVLAALESRGTLADILKAAGATTANITQAIEQMRGGESVNDQGAEDQRQA

LKKYTIDLTERAEQGKLDPVIGRDEEIRRTIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIINGEVPEGLKGRRVLAL

DMGALVAGAKYRGEFEERLKGVLNDLAKQEGNVILFIDELHTMVGAGKADGAMDAGNMLKPALARGELHCVGATTLDEYR

QYIEKDAALERRFQKVFVAEPSVEDTIAILRGLKERYELHHHVQITDPAIVAAATLSHRYIADRQLPDKAIDLIDEAASS

IRMQIDSKPEELDRLDRRIIQLKLEQQALMKESDEASKKRLDMLNEELSDKERQYSELEEEWKAEKASLSGTQTIKAELE

QAKIAIEQARRVGDLARMSELQYGKIPELEKQLEAATQLEGKTMRLLRNKVTDAEIAEVLARWTGIPVSRMMESEREKLL

RMEQELHHRVIGQNEAVDAVSNAIRRSRAGLADPNRPIGSFLFLGPTGVGKTELCKALANFMFDSDEAMVRIDMSEFMEK

HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHPDVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL

GSDLIQERFGELDYAHMKELVLGVVSHNFRPEFINRIDEVVVFHPLGEQHIASIAQIQLKRLYKRLEERGYEIHISDEAL

KLLSENGYDPVYGARPLKRAIQQQIENPLAQQILSGELVPGKVIRLEVNEDRIVAVQ

Nucleotide

Download Length: 2574 bp

                                >NTDB_id=535155 LGS58_RS18775 WP_001235102.1 3892896..3895469(+) (clpC) [Escherichia coli strain BL21(RP)]

ATGCGTCTGGATCGTCTTACTAATAAATTCCAGCTTGCTCTTGCCGATGCCCAATCACTTGCACTCGGGCACGACAACCA

ATTCATCGAACCACTTCATTTAATGAGCGCCCTGCTGAATCAGGAAGGGGGTTCGGTTAGTCCTTTGTTAACATCAGCTG

GCATAAATGCTGGCCAGTTGCGCACAGATATCAATCAGGCATTAAATCGTTTACCGCAGGTTGAAGGTACTGGTGGTGAT

GTCCAGCCATCACAGGATCTGGTGCGCGTTCTTAATCTTTGCGACAAGCTGGCGCAAAAACGTGGTGATAACTTTATCTC

GTCAGAACTGTTCGTTCTGGCGGCACTTGAGTCTCGCGGCACGCTGGCCGACATCCTGAAAGCAGCAGGGGCGACCACCG

CCAACATTACTCAAGCGATTGAACAAATGCGTGGAGGTGAAAGCGTGAACGATCAAGGTGCTGAAGACCAACGTCAGGCT

TTGAAAAAATATACCATCGACCTTACCGAACGAGCCGAACAGGGCAAACTCGATCCGGTGATTGGTCGTGATGAAGAAAT

TCGCCGTACCATTCAGGTGCTGCAACGTCGTACTAAAAATAACCCGGTACTGATTGGTGAACCCGGCGTCGGTAAAACTG

CCATCGTTGAAGGTCTGGCGCAGCGTATTATCAACGGCGAAGTGCCGGAAGGGTTGAAAGGCCGCCGGGTACTGGCGCTG

GATATGGGCGCGCTGGTGGCTGGGGCGAAATATCGCGGTGAGTTTGAAGAACGTTTAAAAGGCGTGCTTAACGATCTTGC

CAAACAGGAAGGCAACGTCATCCTGTTTATCGACGAATTACATACCATGGTCGGCGCGGGTAAAGCCGATGGCGCAATGG

ACGCCGGAAACATGCTGAAACCGGCGCTGGCGCGTGGTGAATTGCACTGCGTAGGTGCCACGACGCTTGACGAATATCGC

CAGTACATCGAAAAAGATGCTGCGCTGGAACGTCGTTTCCAGAAAGTGTTTGTTGCCGAGCCTTCTGTTGAAGATACCAT

TGCGATTCTGCGTGGCCTGAAAGAACGTTACGAATTGCACCACCATGTGCAAATTACTGACCCGGCAATTGTTGCAGCGG

CGACGTTGTCTCATCGCTACATTGCTGACCGTCAGCTGCCGGATAAAGCCATCGACCTGATCGATGAAGCAGCATCCAGC

ATTCGTATGCAGATTGACTCAAAACCAGAAGAACTCGACCGACTCGATCGTCGTATCATCCAGCTCAAACTGGAACAACA

GGCGTTAATGAAAGAGTCTGATGAAGCCAGTAAAAAACGCCTGGATATGCTCAACGAAGAACTGAGCGACAAAGAACGTC

AATACTCCGAGTTAGAAGAAGAGTGGAAAGCAGAGAAGGCATCGCTTTCTGGTACGCAGACCATTAAAGCGGAACTGGAA

CAGGCGAAAATCGCTATTGAACAGGCTCGCCGTGTGGGGGACCTGGCGCGGATGTCTGAACTGCAATACGGCAAAATCCC

GGAACTGGAAAAGCAACTGGAAGCCGCAACGCAGCTCGAAGGCAAAACTATGCGTCTGTTGCGTAATAAAGTGACCGACG

CCGAAATTGCTGAAGTGCTGGCGCGTTGGACGGGGATTCCGGTTTCTCGCATGATGGAAAGCGAGCGCGAAAAACTGCTG

CGTATGGAGCAAGAACTGCACCATCGCGTAATTGGTCAGAACGAAGCGGTTGATGCGGTATCTAACGCTATTCGTCGTAG

CCGTGCGGGGCTGGCGGATCCAAATCGCCCGATTGGTTCATTCCTGTTCCTCGGCCCAACTGGTGTGGGGAAAACAGAGC

TTTGTAAGGCGCTGGCGAACTTTATGTTTGATAGCGACGAGGCGATGGTCCGTATCGATATGTCCGAGTTTATGGAGAAA

CACTCGGTGTCTCGTCTGGTTGGTGCGCCTCCGGGATATGTCGGTTATGAAGAAGGTGGCTACCTGACCGAAGCTGTGCG

TCGTCGTCCGTATTCCGTCATCCTGCTGGATGAAGTGGAAAAAGCGCATCCGGATGTCTTCAATATTCTGTTGCAGGTAC

TGGATGATGGGCGTCTGACTGACGGGCAGGGGAGAACGGTCGACTTCCGTAATACGGTTGTCATTATGACCTCTAACCTC

GGTTCCGATCTGATTCAGGAACGCTTCGGTGAACTGGATTATGCGCACATGAAAGAGCTGGTGCTCGGTGTGGTTAGCCA

TAACTTCCGTCCGGAATTCATTAACCGTATCGATGAAGTGGTGGTCTTCCATCCGCTGGGTGAACAGCACATTGCGTCGA

TTGCGCAGATTCAGTTGAAACGTCTGTATAAACGTCTGGAAGAACGTGGTTATGAAATCCACATTTCTGACGAGGCGCTG

AAACTGCTGAGCGAGAACGGTTACGATCCGGTCTATGGTGCACGTCCTCTGAAACGTGCAATTCAGCAGCAGATCGAAAA

CCCGCTGGCACAGCAAATACTGTCTGGTGAATTGGTTCCGGGTAAAGTGATTCGCCTGGAAGTTAATGAAGACCGGATTG

TCGCCGTCCAGTAA

Domains

Predicted by InterProScan.

AAA lid domain (AAA_lid_9)

(342-443)

ATPase family associated with various cellular activities (AAA) (AAA)

(203-337)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(94-145)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(17-68)

AAA domain (Cdc48 subfamily) (AAA_2)

(596-760)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(766-845)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	P63286

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.816	100	0.485
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.575	100	0.428
clpE	Streptococcus pneumoniae Rx1	47.865	79.23	0.379
clpE	Streptococcus pneumoniae D39	47.865	79.23	0.379
clpE	Streptococcus pneumoniae R6	47.865	79.23	0.379
clpE	Streptococcus pneumoniae TIGR4	47.865	79.23	0.379
clpC	Lactococcus lactis subsp. cremoris KW2	46.377	80.513	0.373
clpE	Streptococcus mutans UA159	46.491	79.813	0.371

Detailed information NTG0535155