Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   I6J12_RS02850 Genome accession   NZ_CP068060
Coordinates   581771..583003 (+) Length   410 a.a.
NCBI ID   WP_003027977.1    Uniprot ID   I0SHV1
Organism   Streptococcus anginosus strain FDAARGOS_1155     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 571424..604062 581771..583003 within 0


Gene organization within MGE regions


Location: 571424..604062
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  I6J12_RS02775 (I6J12_02775) - 571506..571763 (-) 258 WP_003024959.1 metal-sensitive transcriptional regulator -
  I6J12_RS02780 (I6J12_02780) - 571937..572377 (+) 441 WP_020999552.1 hypothetical protein -
  I6J12_RS02785 (I6J12_02785) - 572538..573446 (+) 909 WP_003034976.1 LysR family transcriptional regulator -
  I6J12_RS02790 (I6J12_02790) lspA 573443..573904 (+) 462 WP_003032263.1 signal peptidase II -
  I6J12_RS02795 (I6J12_02795) - 573894..574790 (+) 897 WP_003035060.1 RluA family pseudouridine synthase -
  I6J12_RS02800 (I6J12_02800) - 574938..575279 (+) 342 WP_267471890.1 glutamate 5-kinase -
  I6J12_RS02805 (I6J12_02805) - 575324..576292 (+) 969 WP_003035041.1 aminoglycoside phosphotransferase family protein -
  I6J12_RS02810 (I6J12_02810) - 576377..576718 (+) 342 WP_003035020.1 zinc ribbon domain-containing protein YjdM -
  I6J12_RS02815 (I6J12_02815) - 576726..577361 (+) 636 WP_003035071.1 Pr6Pr family membrane protein -
  I6J12_RS02820 (I6J12_02820) - 577559..578401 (+) 843 WP_003034933.1 hypothetical protein -
  I6J12_RS02825 (I6J12_02825) - 578440..578703 (+) 264 WP_003035068.1 chorismate mutase -
  I6J12_RS02830 (I6J12_02830) - 578719..579936 (+) 1218 WP_003034942.1 voltage-gated chloride channel family protein -
  I6J12_RS02835 (I6J12_02835) - 580022..580861 (+) 840 WP_003034902.1 thymidylate synthase -
  I6J12_RS02840 (I6J12_02840) - 581048..581560 (+) 513 WP_003035097.1 dihydrofolate reductase -
  I6J12_RS02845 (I6J12_02845) - 581560..581733 (+) 174 WP_003035049.1 hypothetical protein -
  I6J12_RS02850 (I6J12_02850) clpX 581771..583003 (+) 1233 WP_003027977.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  I6J12_RS02855 (I6J12_02855) yihA 583015..583602 (+) 588 WP_003035043.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  I6J12_RS02860 (I6J12_02860) - 583723..584430 (+) 708 WP_003035004.1 glucosaminidase domain-containing protein -
  I6J12_RS02865 (I6J12_02865) - 584667..585530 (+) 864 WP_003033304.1 IS982 family transposase -
  I6J12_RS02870 (I6J12_02870) - 585541..587214 (+) 1674 WP_003033502.1 FtsK/SpoIIIE domain-containing protein -
  I6J12_RS02875 (I6J12_02875) - 587497..588738 (+) 1242 WP_003033496.1 replication initiation factor domain-containing protein -
  I6J12_RS02880 (I6J12_02880) - 588717..589106 (+) 390 WP_003033500.1 hypothetical protein -
  I6J12_RS02885 (I6J12_02885) - 589202..589492 (+) 291 WP_003033498.1 hypothetical protein -
  I6J12_RS02890 (I6J12_02890) - 589625..590560 (+) 936 WP_020999554.1 IS30 family transposase -
  I6J12_RS02895 (I6J12_02895) - 590564..591703 (+) 1140 WP_003037865.1 recombinase family protein -
  I6J12_RS02900 (I6J12_02900) - 591648..592955 (+) 1308 WP_080572008.1 recombinase family protein -
  I6J12_RS02905 (I6J12_02905) - 593263..594615 (+) 1353 WP_003037877.1 DUF349 domain-containing protein -
  I6J12_RS02910 (I6J12_02910) - 595346..596524 (+) 1179 WP_020999557.1 hypothetical protein -
  I6J12_RS02915 (I6J12_02915) - 596826..597962 (+) 1137 WP_003037968.1 helix-turn-helix domain-containing protein -
  I6J12_RS02920 (I6J12_02920) - 598470..600161 (+) 1692 WP_003037946.1 phospho-sugar mutase -
  I6J12_RS02925 (I6J12_02925) - 600343..601311 (-) 969 WP_003037832.1 NAD(P)/FAD-dependent oxidoreductase -
  I6J12_RS02930 (I6J12_02930) - 601438..603981 (+) 2544 WP_003037854.1 M1 family metallopeptidase -

Sequence

Protein


Download         Length: 410 a.a.        Molecular weight: 45688.21 Da        Isoelectric Point: 4.4242

>NTDB_id=526795 I6J12_RS02850 WP_003027977.1 581771..583003(+) (clpX) [Streptococcus anginosus strain FDAARGOS_1155]
MPTNRTNEMMVYCSFCGKSQEEVQKIIAGNNAFICNECVELAQEIIREELAEEVLADLSEVPKPQELLNILNHYVIGQDR
AKRALAVAVYNHYKRINFHDNREDEEDVELQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATALTEAGYVGEDVEN
ILLKLLQAADFNIERAERGIIYVDEIDKIAKKSENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPQQEMIQVDT
KNILFIVGGAFDGIEEIVKQRLGEKIIGFGQNNKAIDETGSYMQEIISEDIQKFGLIPELIGRLPVFAALEPLTVDDLVR
ILREPKNALVKQYQTLLSYDDVKLEFDDDALQEIANKAIERKTGARGLRSIIEETMMDVMFEVPSQENVKLVRITKEAVD
GTDKPILETA

Nucleotide


Download         Length: 1233 bp        

>NTDB_id=526795 I6J12_RS02850 WP_003027977.1 581771..583003(+) (clpX) [Streptococcus anginosus strain FDAARGOS_1155]
ATGCCTACAAATCGTACGAACGAAATGATGGTTTATTGTTCTTTTTGTGGTAAAAGCCAAGAAGAAGTTCAAAAAATTAT
CGCAGGAAATAATGCCTTTATTTGTAATGAATGTGTGGAATTAGCACAAGAAATTATTAGAGAAGAATTAGCAGAAGAAG
TGCTGGCAGACTTGTCAGAAGTACCAAAACCGCAAGAACTACTCAATATTTTGAATCATTATGTGATTGGACAAGACCGT
GCTAAGCGAGCATTGGCCGTTGCTGTTTACAATCACTATAAACGCATCAATTTTCATGATAATCGTGAAGATGAGGAAGA
TGTCGAATTGCAGAAATCCAATATCCTCATGATTGGACCAACTGGTTCTGGCAAGACCTTTCTCGCTCAAACCTTGGCGA
AAAGTCTGAATGTTCCTTTTGCGATTGCAGACGCGACAGCTTTGACAGAAGCTGGGTATGTCGGAGAAGATGTTGAAAAT
ATTCTCTTGAAACTCTTGCAAGCAGCAGATTTCAATATTGAGCGTGCAGAACGTGGTATCATCTATGTAGATGAGATTGA
CAAAATTGCGAAGAAAAGCGAAAATGTCTCTATTACTCGCGATGTGTCTGGTGAAGGCGTTCAGCAAGCGCTTCTAAAAA
TCATTGAAGGAACTGTTGCCAGCGTACCTCCGCAAGGCGGCCGCAAGCACCCTCAACAAGAAATGATTCAAGTAGATACG
AAAAATATCCTCTTTATCGTTGGAGGAGCTTTCGACGGTATCGAAGAAATTGTTAAACAACGTCTAGGCGAAAAAATTAT
CGGTTTTGGTCAAAATAATAAAGCCATTGATGAAACTGGTTCTTATATGCAAGAAATCATCTCTGAAGATATTCAAAAAT
TTGGCTTGATTCCGGAATTGATTGGTCGTTTGCCTGTGTTTGCAGCGCTTGAGCCTTTGACAGTTGATGATTTGGTGCGA
ATCCTGCGCGAACCAAAGAATGCTTTAGTGAAGCAATATCAGACTCTCCTTTCTTATGATGATGTTAAACTAGAGTTTGA
TGATGATGCTCTTCAGGAAATTGCTAACAAGGCCATTGAACGCAAGACAGGTGCGCGTGGATTGCGGTCGATTATCGAGG
AAACTATGATGGATGTCATGTTTGAAGTTCCAAGTCAAGAAAATGTGAAGTTAGTGCGGATTACCAAGGAAGCAGTTGAC
GGAACGGATAAGCCGATTTTAGAAACAGCATAA

Domains

Predicted by InterproScan.

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(313-390)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

AAA domain (Cdc48 subfamily) (AAA_2)

(111-306)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0SHV1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

86.829

100

0.868
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.458

98.049

0.573