Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   JJN14_RS07095 Genome accession   NZ_CP067992
Coordinates   1409513..1411771 (+) Length   752 a.a.
NCBI ID   WP_201058263.1    Uniprot ID   -
Organism   Streptococcus mitis strain S022-V7-A3     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1407771..1476260 1409513..1411771 within 0


Gene organization within MGE regions


Location: 1407771..1476260
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JJN14_RS07085 (JJN14_07085) - 1408177..1408860 (-) 684 WP_033686685.1 amino acid ABC transporter permease -
  JJN14_RS07090 (JJN14_07090) - 1409051..1409281 (+) 231 WP_000443570.1 DUF1797 family protein -
  JJN14_RS07095 (JJN14_07095) clpE 1409513..1411771 (+) 2259 WP_201058263.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  JJN14_RS07100 (JJN14_07100) - 1411907..1412359 (+) 453 WP_201058264.1 NUDIX hydrolase -
  JJN14_RS07105 (JJN14_07105) - 1412418..1412717 (+) 300 WP_000767189.1 DUF1827 family protein -
  JJN14_RS07110 (JJN14_07110) - 1412852..1413487 (+) 636 WP_201058265.1 GNAT family N-acetyltransferase -
  JJN14_RS07115 (JJN14_07115) metK 1413571..1414761 (-) 1191 WP_201058266.1 methionine adenosyltransferase -
  JJN14_RS07120 (JJN14_07120) - 1415122..1416465 (-) 1344 WP_061589833.1 DEAD/DEAH box helicase -
  JJN14_RS07125 (JJN14_07125) - 1416758..1417573 (-) 816 WP_201058267.1 endonuclease/exonuclease/phosphatase family protein -
  JJN14_RS07130 (JJN14_07130) - 1417625..1419808 (-) 2184 WP_201058268.1 PTS transporter subunit IIBC -
  JJN14_RS07135 (JJN14_07135) ftsX 1419989..1420915 (-) 927 WP_042751472.1 permease-like cell division protein FtsX -
  JJN14_RS07140 (JJN14_07140) ftsE 1420908..1421600 (-) 693 WP_004263501.1 cell division ATP-binding protein FtsE -
  JJN14_RS07150 (JJN14_07150) - 1422822..1423478 (-) 657 WP_064276923.1 CBS domain-containing protein -
  JJN14_RS07155 (JJN14_07155) - 1423846..1424556 (-) 711 WP_000062200.1 ABC transporter ATP-binding protein -
  JJN14_RS07160 (JJN14_07160) - 1424556..1425320 (-) 765 WP_201058270.1 ABC transporter ATP-binding protein -
  JJN14_RS07165 (JJN14_07165) - 1425320..1426276 (-) 957 WP_000662290.1 branched-chain amino acid ABC transporter permease -
  JJN14_RS07170 (JJN14_07170) - 1426280..1427149 (-) 870 WP_000941421.1 branched-chain amino acid ABC transporter permease -
  JJN14_RS07175 (JJN14_07175) - 1427265..1428425 (-) 1161 WP_070478656.1 ABC transporter substrate-binding protein -
  JJN14_RS07180 (JJN14_07180) - 1428493..1428780 (-) 288 WP_049492230.1 YlbG family protein -
  JJN14_RS07185 (JJN14_07185) clpP 1428859..1429449 (-) 591 WP_000613475.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  JJN14_RS07190 (JJN14_07190) upp 1429623..1430252 (-) 630 WP_201058271.1 uracil phosphoribosyltransferase -
  JJN14_RS07195 (JJN14_07195) - 1430341..1430808 (-) 468 WP_000136976.1 deoxycytidylate deaminase -
  JJN14_RS07200 (JJN14_07200) - 1430827..1431384 (-) 558 WP_201058272.1 TetR/AcrR family transcriptional regulator -
  JJN14_RS07205 (JJN14_07205) - 1431509..1432354 (+) 846 WP_201058273.1 DegV family protein -
  JJN14_RS07210 (JJN14_07210) - 1432413..1433585 (+) 1173 WP_201058274.1 NAD(P)/FAD-dependent oxidoreductase -
  JJN14_RS07215 (JJN14_07215) - 1433634..1434155 (+) 522 WP_201058275.1 DUF1697 domain-containing protein -
  JJN14_RS07220 (JJN14_07220) - 1434197..1434937 (-) 741 WP_201058276.1 MerR family transcriptional regulator -
  JJN14_RS07225 (JJN14_07225) - 1435278..1436618 (+) 1341 WP_201058277.1 sodium-dependent transporter -
  JJN14_RS07230 (JJN14_07230) manA 1436659..1437603 (-) 945 WP_201058278.1 mannose-6-phosphate isomerase, class I -
  JJN14_RS07235 (JJN14_07235) - 1437724..1439162 (-) 1439 Protein_1379 6-phospho-beta-glucosidase -
  JJN14_RS07240 (JJN14_07240) - 1439920..1441137 (-) 1218 WP_001291561.1 tyrosine-type recombinase/integrase -
  JJN14_RS07245 (JJN14_07245) - 1441219..1441422 (-) 204 WP_000814511.1 excisionase -
  JJN14_RS07250 (JJN14_07250) - 1441870..1442100 (-) 231 WP_000845144.1 helix-turn-helix domain-containing protein -
  JJN14_RS07255 (JJN14_07255) - 1442097..1442519 (-) 423 WP_000804878.1 RNA polymerase sigma factor -
  JJN14_RS07260 (JJN14_07260) - 1443051..1443404 (+) 354 WP_001227349.1 helix-turn-helix transcriptional regulator -
  JJN14_RS07265 (JJN14_07265) - 1443462..1443647 (-) 186 WP_413926387.1 cysteine-rich KTR domain-containing protein -
  JJN14_RS07270 (JJN14_07270) tet(M) 1443747..1445666 (-) 1920 WP_201058279.1 tetracycline resistance ribosomal protection protein Tet(M) -
  JJN14_RS07275 (JJN14_07275) - 1445888..1446676 (-) 789 Protein_1387 conjugal transfer protein -
  JJN14_RS10220 - 1446728..1446871 (-) 144 Protein_1388 DUF961 family protein -
  JJN14_RS07280 (JJN14_07280) - 1447306..1447653 (-) 348 WP_201058281.1 VOC family protein -
  JJN14_RS07285 (JJN14_07285) spxB 1447808..1449583 (-) 1776 WP_000191811.1 pyruvate oxidase -
  JJN14_RS07290 (JJN14_07290) - 1449795..1452038 (-) 2244 WP_201058282.1 heavy metal translocating P-type ATPase -
  JJN14_RS07295 (JJN14_07295) - 1452048..1452419 (-) 372 WP_000935055.1 cupredoxin domain-containing protein -
  JJN14_RS07300 (JJN14_07300) - 1452430..1452825 (-) 396 WP_201058283.1 CopY/TcrY family copper transport repressor -
  JJN14_RS07305 (JJN14_07305) thiD 1453191..1453982 (+) 792 WP_201058284.1 bifunctional hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase -
  JJN14_RS07310 (JJN14_07310) - 1454108..1455364 (+) 1257 WP_201058285.1 ISL3 family transposase -
  JJN14_RS07315 (JJN14_07315) thiE 1455450..1456082 (-) 633 WP_201058286.1 thiamine phosphate synthase -
  JJN14_RS07320 (JJN14_07320) - 1456075..1456878 (-) 804 WP_201058287.1 hydroxyethylthiazole kinase -
  JJN14_RS07325 (JJN14_07325) thiW 1456878..1457402 (-) 525 WP_033685230.1 energy coupling factor transporter S component ThiW -
  JJN14_RS07330 (JJN14_07330) tenA 1457407..1458099 (-) 693 WP_201058288.1 thiaminase II -
  JJN14_RS07335 (JJN14_07335) - 1458110..1458760 (-) 651 WP_201058289.1 energy-coupling factor transporter transmembrane component T -
  JJN14_RS07340 (JJN14_07340) - 1458762..1460147 (-) 1386 WP_201058290.1 ATP-binding cassette domain-containing protein -
  JJN14_RS07345 (JJN14_07345) - 1460148..1460708 (-) 561 WP_201058291.1 ECF transporter S component -
  JJN14_RS07350 (JJN14_07350) thiE 1461148..1461780 (-) 633 WP_201058292.1 thiamine phosphate synthase -
  JJN14_RS07355 (JJN14_07355) thiM 1461782..1462564 (-) 783 WP_201058293.1 hydroxyethylthiazole kinase -
  JJN14_RS07360 (JJN14_07360) - 1462840..1463508 (-) 669 WP_201058294.1 TenA family protein -
  JJN14_RS07365 (JJN14_07365) lctO 1463963..1465099 (-) 1137 WP_000120714.1 L-lactate oxidase -
  JJN14_RS07370 (JJN14_07370) pyrE 1465333..1465965 (-) 633 WP_201058295.1 orotate phosphoribosyltransferase -
  JJN14_RS07375 (JJN14_07375) pyrF 1465999..1466700 (-) 702 WP_125386113.1 orotidine-5'-phosphate decarboxylase -
  JJN14_RS07380 (JJN14_07380) - 1466933..1468186 (-) 1254 WP_201058296.1 cell division protein FtsQ/DivIB -
  JJN14_RS07385 (JJN14_07385) - 1468196..1469254 (-) 1059 WP_201058297.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase -
  JJN14_RS07390 (JJN14_07390) murD 1469256..1470608 (-) 1353 WP_125386116.1 UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase -
  JJN14_RS07395 (JJN14_07395) - 1470723..1470977 (-) 255 WP_000262657.1 DUF3165 family protein -
  JJN14_RS07400 (JJN14_07400) typA 1470997..1472838 (-) 1842 WP_000164111.1 translational GTPase TypA -
  JJN14_RS07405 (JJN14_07405) - 1473000..1473725 (+) 726 WP_201058298.1 16S rRNA pseudouridine(516) synthase -
  JJN14_RS07410 (JJN14_07410) - 1473765..1473992 (-) 228 WP_201058299.1 DUF4190 domain-containing protein -
  JJN14_RS07415 (JJN14_07415) - 1474158..1474385 (-) 228 WP_049492311.1 hypothetical protein -
  JJN14_RS07420 (JJN14_07420) - 1474549..1474929 (-) 381 WP_201058300.1 rhodanese-like domain-containing protein -
  JJN14_RS07425 (JJN14_07425) - 1474929..1475198 (-) 270 WP_020901947.1 YqgQ family protein -
  JJN14_RS07430 (JJN14_07430) - 1475262..1476170 (+) 909 WP_084926873.1 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83658.07 Da        Isoelectric Point: 5.3672

>NTDB_id=526164 JJN14_RS07095 WP_201058263.1 1409513..1411771(+) (clpE) [Streptococcus mitis strain S022-V7-A3]
MLCQNCKINDSTIHLYTNLNGKQKQIDLCQNCYKIIKTDPNNSLFKGMTDLNNRDFDPFGDFFNDLNNFRPSNNTPPTPP
TQSGGGYGGNGGYGSQNSGPAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
GDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEL
QKKKVTDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRRNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKAEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVKLMLADVNKRLSSNNIHLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKTSEKEV

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=526164 JJN14_RS07095 WP_201058263.1 1409513..1411771(+) (clpE) [Streptococcus mitis strain S022-V7-A3]
ATGCTTTGTCAAAACTGTAAAATCAATGACTCAACAATTCATCTTTATACCAATCTTAACGGAAAGCAAAAACAAATTGA
CCTTTGTCAAAACTGCTATAAGATTATCAAGACAGATCCTAACAATAGCCTCTTTAAAGGTATGACGGATCTGAACAATC
GTGACTTTGATCCCTTTGGTGATTTCTTCAATGACCTAAACAATTTTAGACCTTCTAACAACACTCCTCCGACTCCCCCA
ACCCAATCAGGTGGAGGCTACGGTGGAAACGGCGGTTATGGTTCCCAAAATAGTGGACCTGCTCAAACTCCTCCACCAAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATCAACGTAACTGAAATTGCCCGTCGTGGAGATATTGACCCCGTTATTG
GGCGCGACGATGAGATTATCCGTGTTATCGAAATTCTCAATCGCAGAACCAAGAATAATCCTGTTCTTATCGGTGAACCA
GGTGTCGGAAAAACTGCCGTTGTCGAAGGTCTAGCTCAGAAAATCGTTGATGGCGACGTTCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCCTAGTTCAAGGAACGGGTATTCGAGGACAATTTGAAGAACGCATGCAAAAGC
TCATGGAAGAAATTCGAAAACGTGAAGACATTATTCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
GGCGATGGCAATATGGATGCAGGAAATATCCTCAAGCCCGCCCTTGCTCGTGGGGAACTGCAACTGGTCGGTGCCACTAC
CCTCAATGAATACCGTATCATTGAAAAAGATGCTGCCCTAGAGCGTCGTATGCAACCTGTTAAGGTCGATGAACCAACAG
TGGACGAAACAATCACAATCCTCAAAGGTATTCAAAAGAAATACGAAGACTACCACCACGTTCAGTATACCGATGCTGCA
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATCGACCTCCTGGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTGATTGATCAACGCTTGATTGAGGCTGAAAATC
TCAAATCTCAAGCTACACGAGAGGAAGATTTTGAGAAGGCAGCTTATTTCCGCGACCAGATTGCCAAGTATAAGGAACTG
CAAAAGAAAAAGGTCACAGACCAAGATACTCCTATCATCAGTGAGAAAACCATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGCGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCTGAAGACCTCAAGTCTCATGTTATTG
GCCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGTCTCGGTACGCCTAACCGCCCAATC
GGAAGCTTCCTATTTGTTGGCCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTAGCCATTGAACTTTTTGGTTC
TGCTGACAGCATGATTCGCTTTGATATGAGTGAATACATGGAAAAACACAGTGTGGCTAAGTTGGTCGGTGCCCCTCCAG
GTTATGTCGGCTACGACGAGGCTGGGCAACTAACTGAAAAAGTCCGCCGTAATCCATATTCTCTCATCCTTCTAGATGAA
GTGGAAAAAGCTCACCCTGATGTTATGCACATGTTCCTTCAAGTCTTGGACGATGGGCGTTTGACAGATGGTCAAGGACG
TACCGTTAGCTTCAAGGATGCCATCATCATTATGACTTCAAATGCCGGGACTGGTAAAGCCGAAGCCAGCGTTGGTTTTG
GAGCTGCTAGAGAAGGACGTACCAATTCTGTTCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGTATTATCGAATTTAAGGCTCTCAGCAAGGACAACCTCCTTCAGATTGTCAAGCTTATGCTTGCAGACGTTAACAA
GCGCCTTTCTAGCAACAACATTCATTTGGATGTAACTGACAAGGTTAAGGAAAAATTGGTTGACCTCGGCTATGATCCAA
AAATGGGGGCGCGCCCACTTCGTCGTACTATTCAAGACTATATTGAAGACGCAATCACTGACTACTACCTTGAAAATCCA
AGTGAAAAAGACCTCAAGGCAGTTATGACCAGCAAGGGCAACATTCAAATCAAATCTGCCAAAAAAGCTGAAGTAAAAAC
TTCTGAAAAAGAAGTATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(155-274)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA lid domain (AAA_lid_9)

(293-390)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

98.269

99.867

0.981
  clpE Streptococcus pneumoniae D39

98.269

99.867

0.981
  clpE Streptococcus pneumoniae R6

98.269

99.867

0.981
  clpE Streptococcus pneumoniae TIGR4

98.136

99.867

0.98
  clpE Streptococcus mutans UA159

83.2

99.734

0.83
  clpC Lactococcus lactis subsp. cremoris KW2

75.626

100

0.763
  clpC Bacillus subtilis subsp. subtilis str. 168

51.863

89.229

0.463
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.166

83.378

0.402
  clpC Streptococcus pneumoniae TIGR4

47.227

83.91

0.396
  clpC Streptococcus pneumoniae Rx1

47.227

83.91

0.396
  clpC Streptococcus pneumoniae D39

47.227

83.91

0.396
  clpC Streptococcus mutans UA159

46.89

83.378

0.391
  clpC Streptococcus thermophilus LMD-9

46.955

82.979

0.39
  clpC Streptococcus thermophilus LMG 18311

46.56

83.112

0.387