Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpX   Type   Regulator
Locus tag   JHX98_RS04010 Genome accession   NZ_CP067010
Coordinates   756972..758201 (+) Length   409 a.a.
NCBI ID   WP_011888976.1    Uniprot ID   A2RF17
Organism   Streptococcus pyogenes strain iGAS376     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 751972..763201
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JHX98_RS03985 (JHX98_03985) - 752588..753865 (-) 1278 WP_002984963.1 hydroxymethylglutaryl-CoA reductase, degradative -
  JHX98_RS03990 (JHX98_03990) - 753852..755027 (-) 1176 WP_011888977.1 hydroxymethylglutaryl-CoA synthase -
  JHX98_RS03995 (JHX98_03995) - 755236..756075 (+) 840 WP_011017679.1 thymidylate synthase -
  JHX98_RS04000 (JHX98_04000) - 756155..756652 (+) 498 WP_011184412.1 dihydrofolate reductase -
  JHX98_RS04005 (JHX98_04005) - 756672..756842 (+) 171 WP_002990165.1 hypothetical protein -
  JHX98_RS04010 (JHX98_04010) clpX 756972..758201 (+) 1230 WP_011888976.1 ATP-dependent Clp protease ATP-binding subunit ClpX Regulator
  JHX98_RS04015 (JHX98_04015) yihA 758211..758810 (+) 600 WP_011184414.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
  JHX98_RS04020 (JHX98_04020) - 758958..759701 (+) 744 WP_002984942.1 hypothetical protein -
  JHX98_RS04025 (JHX98_04025) - 759759..761858 (-) 2100 WP_002984939.1 ATP-dependent Clp protease ATP-binding subunit -
  JHX98_RS04030 (JHX98_04030) rpiA 762236..762919 (+) 684 WP_009881270.1 ribose-5-phosphate isomerase RpiA -

Sequence

Protein


Download         Length: 409 a.a.        Molecular weight: 45006.50 Da        Isoelectric Point: 4.6184

>NTDB_id=524340 JHX98_RS04010 WP_011888976.1 756972..758201(+) (clpX) [Streptococcus pyogenes strain iGAS376]
MAGSRTNDIKVYCSFCGKSQDDVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLDVLNQYVVGQDR
AKRALSVAVYNHYKRVSFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKVIGFGQNSRKIDDNASYMQEIISEDIQKFGLIPEFIGRLPVVAALEQLNTSDLIRI
LTEPRNALVKQYQALLSYDGVELEFDKAALEAIATKAIERKTGARGLRSIIEETMLDIMFEIPSQEDVTKVRITKAAVEG
KSKPVLETA

Nucleotide


Download         Length: 1230 bp        

>NTDB_id=524340 JHX98_RS04010 WP_011888976.1 756972..758201(+) (clpX) [Streptococcus pyogenes strain iGAS376]
ATGGCAGGAAGTAGAACTAACGATATTAAAGTATACTGTTCATTTTGTGGTAAAAGCCAGGATGACGTTAAAAAAATTAT
CGCAGGAAATAATGTTTTCATCTGCAATGAATGCGTAGCTTTATCACAAGAAATTATAAAAGAAGAATTGGCTGAAGAAG
TCCTTGCCGATTTGACAGAAGTTCCAAAACCAAAAGAGCTCCTTGATGTTTTAAATCAATATGTGGTTGGTCAAGATCGT
GCTAAACGTGCTTTATCAGTTGCTGTGTACAATCATTATAAGCGTGTCTCGTTTACAGAAAGTCGTGATGACGATGATGT
GGATTTACAAAAGTCTAACATTTTGATGATTGGACCAACAGGTTCAGGAAAAACCTTCTTAGCACAAACTCTGGCTAAAA
GCCTCAATGTACCATTTGCTATTGCAGATGCAACTTCTTTGACTGAAGCAGGGTATGTTGGAGAAGATGTGGAAAATATT
TTACTCAAACTGATTCAGGCTGCTGACTATAATGTCGAACGAGCAGAGCGTGGTATTATTTATGTTGATGAAATAGATAA
GATTGCTAAAAAAGGTGAGAACGTATCTATCACACGTGATGTATCTGGTGAAGGTGTACAGCAAGCCCTTCTTAAAATTA
TTGAAGGTACGGTAGCAAGTGTTCCCCCACAAGGTGGGCGGAAGCACCCTAATCAAGAAATGATCCAAATTGATACAAAA
AATATCTTGTTTATTGTTGGCGGGGCTTTTGATGGCATCGAGGAGATTGTTAAACAACGTTTAGGTGAAAAAGTTATTGG
TTTTGGTCAAAACAGCCGTAAAATTGATGACAATGCTTCTTATATGCAAGAAATTATTTCAGAAGATATTCAAAAGTTTG
GGCTTATTCCAGAATTTATTGGCCGCTTACCAGTTGTGGCAGCCCTTGAACAACTAAACACATCAGATTTGATTCGAATC
TTAACAGAGCCAAGGAATGCTCTTGTCAAGCAATATCAGGCCCTTCTTTCCTATGATGGGGTTGAATTAGAATTTGATAA
AGCAGCTCTTGAAGCTATCGCAACTAAAGCCATTGAACGTAAGACAGGAGCACGTGGTCTTCGTTCTATTATCGAAGAAA
CGATGCTTGACATCATGTTTGAAATTCCAAGCCAAGAAGATGTCACAAAAGTGCGTATCACCAAGGCTGCTGTCGAAGGC
AAGTCAAAACCCGTTTTAGAGACAGCTTAA

Domains

Predicted by InterproScan.

AAA domain (Cdc48 subfamily) (AAA_2)

(110-305)

ClpX C4-type zinc finger (zf-C4_ClpX)

(12-48)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(312-391)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A2RF17

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpX Streptococcus mutans UA159

88.998

100

0.89
  clpX Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.853

98.044

0.577