Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR/comR1   Type   Regulator
Locus tag   SMUGS5_RS01675 Genome accession   NC_018089
Coordinates   336843..337745 (-) Length   300 a.a.
NCBI ID   WP_002262469.1    Uniprot ID   Q8DVT6
Organism   Streptococcus mutans GS-5     
Function   repress natural transformation (predicted from homology)   
Competence regulation

Genomic Context

Location: 331843..342745
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SMUGS5_RS01650 (SMUGS5_01550) - 331997..332740 (+) 744 WP_002262476.1 methyltransferase domain-containing protein -
  SMUGS5_RS01655 (SMUGS5_01555) - 332727..333437 (+) 711 WP_002262475.1 SDR family NAD(P)-dependent oxidoreductase -
  SMUGS5_RS01660 (SMUGS5_01560) - 333448..334356 (+) 909 WP_002262474.1 hypothetical protein -
  SMUGS5_RS01665 (SMUGS5_01565) - 334372..335610 (+) 1239 WP_002274164.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
  SMUGS5_RS10530 - 335815..335964 (+) 150 WP_002271212.1 hypothetical protein -
  SMUGS5_RS01670 (SMUGS5_01570) - 335982..336221 (+) 240 WP_002262471.1 hypothetical protein -
  SMUGS5_RS09960 (SMUGS5_01575) - 336199..336336 (+) 138 WP_002262470.1 hypothetical protein -
  SMUGS5_RS01675 (SMUGS5_01580) comR/comR1 336843..337745 (-) 903 WP_002262469.1 helix-turn-helix domain-containing protein Regulator
  SMUGS5_RS01680 (SMUGS5_01585) - 338120..339088 (-) 969 WP_032505910.1 aldo/keto reductase -
  SMUGS5_RS01685 (SMUGS5_01590) - 339109..340155 (-) 1047 WP_002262467.1 SDR family oxidoreductase -
  SMUGS5_RS01690 (SMUGS5_01595) - 340329..340787 (+) 459 WP_014834831.1 MarR family winged helix-turn-helix transcriptional regulator -
  SMUGS5_RS01695 (SMUGS5_01600) tsaB 340798..341484 (+) 687 WP_002264346.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB -
  SMUGS5_RS01700 (SMUGS5_01605) rimI 341484..341918 (+) 435 WP_002264347.1 ribosomal protein S18-alanine N-acetyltransferase -

Sequence

Protein


Download         Length: 300 a.a.        Molecular weight: 35007.28 Da        Isoelectric Point: 4.5017

>NTDB_id=52013 SMUGS5_RS01675 WP_002262469.1 336843..337745(-) (comR/comR1) [Streptococcus mutans GS-5]
MTIKEDLGRRIKAERNRKQLTQSLLCGDETKLTIRQLQRIEGGQSLPTLEKLEFIADRLGTKIADLLEGSDIQLPDDYWE
LKGQIVKFPTYADKERLQQKQELIEEIYDKYFDILPEDELLFLDLSENILDSFHEKDIPNIEEIYDDAFEQVLKKETFAF
NDYLYMSYFLQKCGKTADYDQTTFKLLEQKLLKQELTVDELYNIELLIAVMEASGVYALHNDYQNLLPLMKKAQRIIDKA
QLHTYKPPLLELEAKYYVKVVKDKKKAKELYQQALVMGEVLGDPVIIADVKMEMANDGID

Nucleotide


Download         Length: 903 bp        

>NTDB_id=52013 SMUGS5_RS01675 WP_002262469.1 336843..337745(-) (comR/comR1) [Streptococcus mutans GS-5]
ATGACAATAAAAGAAGATTTAGGACGGCGGATTAAAGCAGAAAGGAATCGCAAGCAACTCACACAAAGCCTTTTGTGCGG
AGATGAAACAAAACTGACCATTCGACAGCTTCAGCGGATTGAGGGCGGGCAGTCTTTGCCGACCCTAGAAAAATTAGAAT
TCATTGCTGATCGCTTAGGAACTAAAATAGCCGACCTGCTGGAAGGCAGCGATATCCAGCTGCCAGATGATTACTGGGAG
CTAAAGGGGCAGATTGTTAAATTTCCCACCTATGCTGATAAGGAAAGACTTCAGCAAAAACAGGAGCTGATCGAAGAAAT
CTATGACAAATACTTTGATATCCTGCCTGAGGATGAACTGCTCTTTTTAGATTTGTCAGAGAATATCCTAGACAGTTTTC
ATGAAAAAGACATTCCTAACATTGAGGAGATTTACGACGATGCCTTTGAGCAAGTCCTCAAAAAGGAGACCTTTGCCTTT
AATGACTATCTTTACATGAGCTATTTTTTACAAAAGTGCGGAAAAACAGCGGACTATGATCAGACAACTTTCAAGTTGCT
TGAGCAAAAATTGCTCAAGCAAGAGCTAACAGTAGACGAACTTTATAATATTGAACTTTTGATTGCTGTTATGGAGGCAT
CAGGTGTTTATGCCCTTCATAATGATTACCAGAATCTTCTTCCTTTAATGAAGAAGGCTCAGCGAATTATTGATAAGGCT
CAGCTTCACACCTATAAACCGCCACTTTTAGAACTTGAAGCCAAGTACTATGTCAAGGTTGTCAAGGATAAGAAAAAAGC
TAAGGAACTCTATCAGCAAGCCTTGGTGATGGGCGAAGTTCTAGGTGATCCTGTTATAATTGCAGATGTTAAGATGGAGA
TGGCAAATGATGGGATAGACTAG

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(75-294)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q8DVT6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

75.667

100

0.757
  comR/comR2 Streptococcus sobrinus strain NIDR 6715-7

69.333

100

0.693
  comR Streptococcus salivarius strain HSISS4

42.475

99.667

0.423
  comR Streptococcus thermophilus LMD-9

42.14

99.667

0.42
  comR Streptococcus thermophilus LMG 18311

42.14

99.667

0.42
  comR Streptococcus salivarius SK126

41.472

99.667

0.413

Multiple sequence alignment