Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SCIM_RS02825 Genome accession   NC_018073
Coordinates   564935..565681 (-) Length   248 a.a.
NCBI ID   WP_037589556.1    Uniprot ID   -
Organism   Streptococcus intermedius JTH08     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 559935..570681
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SCIM_RS02810 (SCIM_0496) - 561927..563288 (+) 1362 WP_003078103.1 bacteriocin secretion accessory protein -
  SCIM_RS02815 - 563402..563536 (+) 135 WP_004233948.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SCIM_RS10055 - 563617..564438 (-) 822 WP_231840239.1 sensor histidine kinase -
  SCIM_RS02825 (SCIM_0498) comE/blpR 564935..565681 (-) 747 WP_037589556.1 response regulator transcription factor Regulator
  SCIM_RS02830 (SCIM_0499) - 565850..566563 (-) 714 WP_004233848.1 CPBP family intramembrane glutamic endopeptidase -
  SCIM_RS02835 - 566795..567022 (+) 228 WP_004233901.1 bacteriocin -
  SCIM_RS02840 (SCIM_0500) - 567058..567378 (+) 321 WP_003073339.1 hypothetical protein -
  SCIM_RS02845 - 567608..567823 (+) 216 WP_004233876.1 bacteriocin class II family protein -
  SCIM_RS02850 (SCIM_0501) - 568051..568344 (+) 294 WP_004233800.1 bacteriocin immunity protein -
  SCIM_RS02855 - 568438..568662 (+) 225 WP_004234003.1 Blp family class II bacteriocin -
  SCIM_RS09905 - 569078..569224 (+) 147 WP_004233732.1 hypothetical protein -
  SCIM_RS02865 - 570001..570231 (+) 231 WP_004233981.1 Blp family class II bacteriocin -

Sequence

Protein


Download         Length: 248 a.a.        Molecular weight: 28757.19 Da        Isoelectric Point: 7.6681

>NTDB_id=51863 SCIM_RS02825 WP_037589556.1 564935..565681(-) (comE/blpR) [Streptococcus intermedius JTH08]
MNIFILEDDLTQQYYMETIVEEIIEKHRLQYHHFEVFGKPKQLLEAISEKGSHQVFFLDIEIKTEEKKGLDVAKKIREID
PYAIIVFVTSHSELMPAAFKLQVGALDYLDKSLSKEALKKRIETALLHTENLTGKGLADDSLLFETPHTQIQVPFKDILY
IETSSRPHRLVLYTHRGRTEFTANLSDMLKKEKRFYQCHRSFVVNPANVHQMDKVNHILHFQNGATCLVSRSKIKGLTEA
IAALHRRE

Nucleotide


Download         Length: 747 bp        

>NTDB_id=51863 SCIM_RS02825 WP_037589556.1 564935..565681(-) (comE/blpR) [Streptococcus intermedius JTH08]
ATGAATATTTTTATTTTAGAAGATGATCTTACTCAACAATATTATATGGAGACTATTGTTGAAGAAATTATCGAAAAACA
TCGTCTTCAATATCACCATTTTGAAGTTTTTGGAAAACCTAAACAATTACTAGAAGCCATATCTGAGAAAGGAAGCCATC
AGGTTTTCTTTTTGGATATTGAAATCAAAACTGAAGAAAAAAAGGGCTTAGACGTCGCCAAAAAGATACGCGAGATAGAT
CCTTATGCCATTATTGTCTTTGTAACCAGTCACTCTGAATTGATGCCGGCAGCGTTTAAACTGCAAGTCGGCGCCCTTGA
CTATCTTGACAAATCGTTATCAAAAGAAGCTTTGAAAAAACGGATCGAAACTGCGCTGCTACATACTGAAAACCTAACAG
GCAAAGGCCTGGCAGACGATTCTCTTCTCTTTGAAACACCTCATACACAAATACAAGTGCCGTTTAAAGATATTCTTTAC
ATTGAAACTTCCTCTCGTCCTCACCGTTTAGTACTTTACACACATAGAGGGCGTACGGAATTTACTGCCAATCTTTCAGA
TATGTTAAAAAAAGAAAAACGGTTCTACCAATGTCATCGTTCCTTTGTTGTTAACCCAGCTAATGTTCATCAAATGGATA
AAGTAAATCATATCCTTCACTTCCAGAATGGTGCTACTTGTCTTGTTTCTAGATCAAAAATAAAAGGGTTAACAGAAGCT
ATTGCAGCCCTGCACCGGAGGGAATGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

49.798

99.597

0.496
  comE/comE1 Streptococcus equinus JB1

45.992

95.565

0.44

Multiple sequence alignment