Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYH   Type   Machinery gene
Locus tag   JAN99_RS00690 Genome accession   NZ_CP065927
Coordinates   105750..106703 (+) Length   317 a.a.
NCBI ID   WP_002987790.1    Uniprot ID   A0A5S4TCX5
Organism   Streptococcus pyogenes strain emm9ST603     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 100750..111703
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  JAN99_RS00650 (JAN99_00645) - 101577..101942 (+) 366 WP_002986560.1 DUF1033 family protein -
  JAN99_RS00655 (JAN99_00650) comYA 102035..102973 (+) 939 WP_002993471.1 competence type IV pilus ATPase ComGA Machinery gene
  JAN99_RS00660 (JAN99_00655) comYB 102909..103943 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  JAN99_RS00665 (JAN99_00660) comYC 103945..104271 (+) 327 WP_002986552.1 competence type IV pilus major pilin ComGC Machinery gene
  JAN99_RS00670 (JAN99_00665) comGD 104246..104674 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  JAN99_RS00675 (JAN99_00670) comGE 104631..104915 (+) 285 WP_269460045.1 competence type IV pilus minor pilin ComGE -
  JAN99_RS00680 (JAN99_00675) comYF 104908..105342 (+) 435 WP_002987783.1 competence type IV pilus minor pilin ComGF Machinery gene
  JAN99_RS00685 (JAN99_00680) comGG 105326..105652 (+) 327 WP_009880358.1 competence type IV pilus minor pilin ComGG -
  JAN99_RS00690 (JAN99_00685) comYH 105750..106703 (+) 954 WP_002987790.1 class I SAM-dependent methyltransferase Machinery gene
  JAN99_RS00695 (JAN99_00690) - 106762..107958 (+) 1197 WP_002987791.1 acetate kinase -
  JAN99_RS00700 (JAN99_00695) - 108145..108453 (+) 309 WP_010921804.1 hypothetical protein -
  JAN99_RS00705 (JAN99_00700) proC 108536..109306 (-) 771 WP_111692971.1 pyrroline-5-carboxylate reductase -
  JAN99_RS00710 (JAN99_00705) pepA 109354..110421 (-) 1068 WP_011054119.1 glutamyl aminopeptidase -
  JAN99_RS00715 (JAN99_00710) - 110886..111170 (+) 285 WP_002992749.1 DUF4651 domain-containing protein -
  JAN99_RS00720 (JAN99_00715) - 111167..111484 (+) 318 WP_111688394.1 thioredoxin family protein -

Sequence

Protein


Download         Length: 317 a.a.        Molecular weight: 35985.08 Da        Isoelectric Point: 4.7205

>NTDB_id=515346 JAN99_RS00690 WP_002987790.1 105750..106703(+) (comYH) [Streptococcus pyogenes strain emm9ST603]
MTFEKIEEAYQLLLENCQLIENDLKTHIYDAIVEQNSFYLGAEGASPQVAQNSDKLKALCLTKEEWRKAYQFLFIKAAQT
EQLQANHQFTPDAIGFILLYLLEQLSDKDSLEVLEIGSGTGNLAQTLLNNTSKSLDYVGIELDDLLIDLSASIAEIMDSS
AHFIQEDAVRPQLLKESDIVISDLPVGYYPNDDIAKRYKVASSDKHTYAHHLLMEQSLKYLKKDGFAIFLAPVNLLTSPQ
SQLLKQWLKDYAQVVALITLPDSIFGHPSNAKSIIVLQKQTDHPMETFVYPIRDLKLAENIHDFMENFKKWKLSNVN

Nucleotide


Download         Length: 954 bp        

>NTDB_id=515346 JAN99_RS00690 WP_002987790.1 105750..106703(+) (comYH) [Streptococcus pyogenes strain emm9ST603]
ATGACTTTTGAAAAAATTGAAGAAGCTTATCAGCTGCTCTTAGAGAACTGTCAACTAATTGAAAATGATCTAAAAACACA
TATATACGATGCCATTGTTGAACAAAACTCCTTTTATTTAGGGGCTGAGGGAGCTAGTCCTCAAGTTGCTCAAAATAGTG
ATAAACTGAAAGCCTTGTGCCTGACAAAAGAAGAATGGCGTAAGGCCTACCAGTTTCTTTTTATTAAGGCAGCTCAGACT
GAGCAACTCCAAGCCAACCATCAGTTCACACCAGATGCTATTGGCTTCATTCTGCTGTATCTTTTGGAACAATTGAGTGA
TAAAGATAGCTTAGAGGTACTTGAGATTGGAAGTGGAACAGGGAACCTAGCCCAAACCCTTCTCAACAACACGAGCAAGA
GCCTTGATTATGTAGGGATTGAACTTGATGATCTCTTGATTGATCTGTCAGCCAGTATTGCTGAAATAATGGATTCTTCA
GCTCATTTTATTCAAGAAGATGCGGTAAGGCCTCAATTACTAAAAGAAAGTGACATTGTCATCAGTGACTTACCAGTTGG
TTATTATCCTAACGATGATATTGCCAAACGGTACAAGGTGGCTAGTTCAGATAAGCATACCTATGCCCATCATTTATTAA
TGGAACAGTCTTTAAAATACTTGAAAAAAGACGGTTTTGCGATTTTTCTGGCACCAGTCAATTTATTGACGAGCCCTCAG
AGCCAGTTATTGAAACAGTGGTTAAAAGATTATGCTCAGGTGGTGGCCTTGATTACGCTACCAGATTCTATTTTTGGTCA
TCCCTCAAATGCCAAGTCCATTATTGTCTTACAAAAACAAACAGACCACCCAATGGAAACCTTTGTCTATCCAATTCGGG
ATTTGAAGCTTGCAGAGAATATTCATGATTTTATGGAAAATTTCAAAAAATGGAAACTGAGTAATGTCAATTAA

Domains

Predicted by InterproScan.

N-6 DNA Methylase (N6_Mtase)

(68-288)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TCX5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYH Streptococcus mutans UA159

66.139

99.685

0.659
  comYH Streptococcus mutans UA140

65.823

99.685

0.656