Detailed information NTG0512409

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: I6G86_RS09650
• Genome accession: NZ_CP065637
• Coordinates: 1877069..1878559 (-)
• Length: 496 a.a.
• NCBI ID: WP_042217260.1
• Uniprot ID: A0A1I4FU19
• Organism: Lactococcus garvieae strain FDAARGOS_929
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1872069..1883559

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I6G86_RS09635 (I6G86_09640)	murD	1872863..1874224 (-)	1362	WP_004259085.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
I6G86_RS09640 (I6G86_09645)	-	1874363..1875100 (-)	738	WP_042217256.1	amino acid ABC transporter ATP-binding protein	-
I6G86_RS09645 (I6G86_09650)	-	1875101..1876672 (-)	1572	WP_042217258.1	ABC transporter permease subunit	-
I6G86_RS09650 (I6G86_09655)	covS	1877069..1878559 (-)	1491	WP_042217260.1	HAMP domain-containing histidine kinase	Regulator
I6G86_RS09655 (I6G86_09660)	covR	1878648..1879343 (-)	696	WP_004259096.1	response regulator transcription factor	Regulator
I6G86_RS09660 (I6G86_09665)	-	1879445..1879996 (-)	552	WP_023889673.1	DUF177 domain-containing protein	-
I6G86_RS09665 (I6G86_09670)	-	1880213..1880455 (-)	243	WP_003135050.1	type B 50S ribosomal protein L31	-
I6G86_RS09670 (I6G86_09675)	-	1880567..1882471 (-)	1905	WP_014024348.1	fructose-specific PTS transporter subunit EIIC	-
I6G86_RS09675 (I6G86_09680)	pfkB	1882486..1883412 (-)	927	WP_042217267.1	1-phosphofructokinase	-

Sequence

Protein

• Length: 496 a.a.
• Molecular weight: 56767.76 Da
• Isoelectric Point: 5.1990

>NTDB_id=512409 I6G86_RS09650 WP_042217260.1 1877069..1878559(-) (covS) [Lactococcus garvieae strain FDAARGOS_929]
MVKFFDSKKKKTESLPERKRSIMLRWAFANTIFCFITFTIFTVLVYQLTITTFINSEKEDMMKALDNVEQSLSQSESTLS
EENLANYLAYAKDYTASSQGKENELETLGSMIGSRKSFYVFDVGENLIYSTNSHGFPLKKDVGDGTHAVRTFGEYSGYLV
ERPVYSNKTGKLIGYVQAFYDMSYYYSVRTKLLIALIILEIIALFIAQFVGYFMASRYIKPLERLHDAITTRANNLKADF
KPVVIQTGDEIEELATVYNDMMIKLNDYVDQQKRFVSDVSHELRTPLAVLDGHLNLLNRWGKNDPEVLEESLQASIEEVS
TMRTMLEEMLALARLENIDFQDEDLICDPTEVSNFLKKNFLLIHADLSLTVENNLSPGRLAHIYPNHYEQGLKILIDNAI
KYSPKDRQEVKIHLEEDDKYIITTVEDHGYGISQEDLKHVFERFFRADKARNRDIGGTGLGLSIIQRIVENYDGEVSVTS
VVGEGSKFTLKIPKIK

Nucleotide

• Length: 1491 bp

>NTDB_id=512409 I6G86_RS09650 WP_042217260.1 1877069..1878559(-) (covS) [Lactococcus garvieae strain FDAARGOS_929]
ATGGTAAAATTTTTTGATTCGAAGAAGAAAAAAACAGAAAGTCTTCCCGAGCGTAAGCGAAGCATCATGCTCCGTTGGGC
ATTTGCAAATACGATTTTTTGTTTTATTACCTTCACTATTTTTACAGTATTGGTTTATCAATTGACCATTACAACCTTCA
TCAATTCTGAAAAAGAGGATATGATGAAAGCTCTGGATAATGTTGAGCAAAGTTTGTCCCAATCGGAAAGCACACTGTCG
GAAGAAAATCTGGCGAATTATTTGGCTTATGCCAAAGACTATACAGCCTCCAGTCAGGGTAAAGAAAATGAGCTAGAAAC
ACTTGGAAGTATGATTGGCTCTAGGAAGTCCTTTTATGTTTTTGACGTCGGTGAAAATTTGATTTACTCGACCAATTCTC
ATGGCTTCCCTCTAAAAAAAGACGTGGGGGATGGCACTCATGCTGTACGTACATTTGGTGAATATTCTGGTTATTTGGTG
GAACGACCGGTTTATTCTAATAAAACAGGTAAGCTGATTGGCTATGTACAGGCTTTCTATGATATGAGTTATTATTATAG
CGTGCGAACAAAGTTACTGATTGCCCTGATTATCTTAGAGATTATTGCTCTCTTTATCGCTCAGTTTGTCGGTTATTTTA
TGGCGAGTCGTTACATCAAGCCTCTGGAACGGTTGCACGATGCGATTACTACACGTGCCAATAACTTGAAGGCGGATTTC
AAACCTGTAGTGATTCAAACAGGTGATGAAATTGAAGAACTGGCGACTGTTTATAATGACATGATGATCAAGCTTAACGA
TTATGTTGATCAGCAGAAACGTTTTGTTTCTGATGTCAGTCACGAGTTACGTACGCCACTTGCGGTTTTGGATGGTCATT
TGAATCTCTTGAACCGTTGGGGGAAAAACGATCCCGAAGTGCTTGAGGAGTCTTTACAGGCCAGTATAGAAGAAGTGAGT
ACGATGAGAACAATGTTGGAAGAGATGCTTGCATTGGCCCGTCTTGAAAACATCGATTTTCAAGATGAAGACCTTATCTG
TGATCCGACAGAAGTTTCTAATTTCCTTAAGAAAAACTTCCTACTTATTCATGCTGATTTAAGCTTAACTGTGGAAAATA
ACTTGTCACCGGGAAGATTGGCTCATATCTACCCGAACCATTATGAACAAGGCTTAAAAATTTTGATTGATAATGCTATA
AAATATTCGCCTAAAGATCGCCAAGAAGTGAAAATTCATCTAGAAGAAGATGATAAATACATTATCACTACGGTTGAGGA
TCATGGCTATGGCATTAGTCAGGAAGATTTAAAACATGTCTTTGAGCGTTTCTTCCGTGCTGATAAAGCGCGAAATCGGG
ATATAGGAGGCACTGGGCTTGGACTGTCTATTATCCAACGCATAGTGGAAAACTATGATGGGGAGGTCAGTGTGACTTCT
GTTGTAGGTGAGGGATCGAAATTCACTTTAAAAATTCCTAAGATTAAATAG

Domains

Predicted by InterproScan.

• HAMP domain (HAMP) (214-266)

• His Kinase A (phospho-acceptor) domain (HisKA) (272-337)

• ArlS sensor domain (ArlS_N) (52-190)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (389-494)

3D structure

• AlphaFold DB: A0A1I4FU19

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	56.137	100	0.563