Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/blpH   Type   Regulator
Locus tag   SIR_RS15610 Genome accession   NC_022246
Coordinates   1209213..1210529 (+) Length   438 a.a.
NCBI ID   WP_021002968.1    Uniprot ID   T1ZF09
Organism   Streptococcus intermedius B196     
Function   phosphorylation of ComE; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1204213..1215529
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SIR_RS15565 (SIR_1144) - 1204538..1204828 (-) 291 WP_021002960.1 bacteriocin immunity protein -
  SIR_RS20345 - 1204895..1205113 (-) 219 Protein_1132 garvicin Q family class II bacteriocin -
  SIR_RS15570 (SIR_1145) - 1205121..1205441 (-) 321 WP_039677379.1 hypothetical protein -
  SIR_RS15580 (SIR_1147) - 1206118..1206339 (-) 222 WP_021002963.1 Blp family class II bacteriocin -
  SIR_RS15585 (SIR_1148) - 1206681..1206872 (-) 192 WP_021002964.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  SIR_RS15590 (SIR_1149) - 1206892..1207140 (-) 249 WP_021002965.1 bacteriocin class II family protein -
  SIR_RS15595 - 1207385..1207564 (+) 180 WP_041787481.1 hypothetical protein -
  SIR_RS15600 (SIR_1150) - 1207583..1208296 (+) 714 WP_021002966.1 CPBP family intramembrane glutamic endopeptidase -
  SIR_RS15605 (SIR_1151) comE/blpR 1208465..1209211 (+) 747 WP_041787711.1 response regulator transcription factor Regulator
  SIR_RS15610 (SIR_1152) comD/blpH 1209213..1210529 (+) 1317 WP_021002968.1 sensor histidine kinase Regulator
  SIR_RS15615 (SIR_1153) - 1210610..1210762 (-) 153 WP_003073362.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  SIR_RS15620 (SIR_1154) - 1210859..1212220 (-) 1362 WP_021002969.1 bacteriocin secretion accessory protein -
  SIR_RS15625 (SIR_1155) comA/nlmT 1212231..1214381 (-) 2151 WP_021002970.1 peptide cleavage/export ABC transporter Regulator
  SIR_RS15630 (SIR_1156) - 1214862..1215236 (+) 375 WP_041787483.1 hypothetical protein -

Sequence

Protein


Download         Length: 438 a.a.        Molecular weight: 49860.54 Da        Isoelectric Point: 7.0030

>NTDB_id=51115 SIR_RS15610 WP_021002968.1 1209213..1210529(+) (comD/blpH) [Streptococcus intermedius B196]
MYILLQLFVIISEMACVPILYSLISGKEFNILTYISIILGNFIIGILLMSTPENFINYLIHPIYFIVISWILGKEGSTTL
KIFYALFPITLINILHRLIGIFILPLFGVSVNILNASLLGNRLLSIFTSVIAFLFLKGNQYQFHSLADQSINYKDKRILV
ITNVSMVLYYIILQLLAYIEYTKFTTTLFVREALVIIYLVFFLIITNRLDLHLRERIQSDLMLQKDLQLKNLENYSHHIE
ELYTEVRSFRHDYANILTTLKLGIEQNDIGIVKNVYHSVLKDSNKRFRNPKYDIGRLVHIKNDALKSLLAAKFAQAQEHN
VSVSLEVPEDICPQGMELVDFITIVSILCDNAIEAAAPTMTIAYVLSGNKQVFSIENAIKEEHIDMSYIFDAGVSSKGSG
RGIGLSNVLAILDRYPNVSLASTSQNHCFQHILEIHLN

Nucleotide


Download         Length: 1317 bp        

>NTDB_id=51115 SIR_RS15610 WP_021002968.1 1209213..1210529(+) (comD/blpH) [Streptococcus intermedius B196]
ATGTATATACTATTACAACTTTTTGTAATTATATCAGAGATGGCTTGTGTACCTATTTTATATTCATTAATCAGCGGAAA
GGAGTTCAATATATTAACCTATATTTCTATAATATTAGGCAATTTTATTATAGGTATTTTGTTAATGTCTACCCCTGAAA
ATTTTATAAATTATTTAATTCATCCAATTTATTTTATTGTGATTTCGTGGATACTTGGAAAAGAAGGAAGTACTACCTTA
AAAATATTTTATGCACTTTTTCCTATTACTTTAATTAATATTTTACATCGCTTAATAGGAATTTTTATTCTTCCTTTGTT
TGGAGTTAGTGTAAACATACTAAATGCTAGCTTACTGGGAAATAGACTTCTCTCTATTTTTACATCAGTGATAGCATTTT
TATTTCTAAAAGGAAATCAATATCAGTTTCATAGTTTAGCGGACCAATCTATAAATTATAAAGACAAAAGAATTCTTGTT
ATCACAAATGTGAGTATGGTATTGTACTATATCATTCTCCAACTATTGGCGTATATAGAATACACTAAATTTACAACAAC
TCTTTTTGTTAGAGAAGCATTGGTTATTATTTATCTAGTATTCTTTTTGATTATTACTAACCGACTGGACCTTCATTTAC
GGGAGAGAATCCAAAGTGATTTAATGCTTCAAAAAGATTTACAGTTAAAAAACTTGGAAAACTACAGTCATCACATTGAG
GAATTGTACACAGAAGTTCGGAGCTTTCGGCATGATTACGCAAATATTTTAACAACCTTGAAATTAGGAATTGAGCAAAA
TGATATAGGCATTGTAAAGAATGTTTATCATTCTGTTTTGAAAGATTCCAATAAGCGTTTTCGCAATCCCAAGTATGATA
TTGGACGGTTAGTCCATATCAAAAACGATGCCTTAAAAAGCCTGCTAGCTGCTAAATTTGCACAAGCTCAAGAGCATAAT
GTATCCGTTTCATTGGAGGTTCCAGAAGATATTTGTCCACAAGGAATGGAATTAGTTGACTTTATCACCATTGTCTCCAT
TTTGTGTGATAATGCGATTGAAGCTGCTGCTCCAACTATGACGATTGCTTATGTTTTGTCAGGAAACAAGCAGGTATTCT
CCATTGAAAATGCTATAAAAGAAGAGCATATAGACATGTCTTATATTTTTGATGCGGGAGTTAGTTCTAAAGGATCTGGG
CGAGGAATTGGATTATCAAATGTCTTAGCAATTCTGGATCGATATCCAAATGTTTCACTTGCTAGTACTAGCCAGAATCA
CTGCTTTCAGCACATCCTTGAGATTCATCTGAATTAG

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(336-433)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB T1ZF09

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/blpH Streptococcus mutans UA159

39.13

94.521

0.37

Multiple sequence alignment