Detailed information    

insolico Bioinformatically predicted

Overview

Name   covS   Type   Regulator
Locus tag   STR1_RS01635 Genome accession   NZ_CP065486
Coordinates   309216..310733 (+) Length   505 a.a.
NCBI ID   WP_084828485.1    Uniprot ID   A0A0E2Q5R4
Organism   Streptococcus thermophilus strain R1     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 304216..315733
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  STR1_RS01605 - 304495..304665 (+) 171 Protein_276 ascorbate 6-phosphate lactonase -
  STR1_RS01610 (STR1_01615) - 304682..305353 (-) 672 WP_064355629.1 TrkA family potassium uptake protein -
  STR1_RS01615 (STR1_01620) - 305393..306757 (-) 1365 WP_095559235.1 potassium transporter TrkG -
  STR1_RS01620 (STR1_01625) rsmG 306827..307540 (-) 714 WP_002949634.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  STR1_RS01625 (STR1_01630) - 307837..308373 (+) 537 WP_065972912.1 YceD family protein -
  STR1_RS01630 (STR1_01635) covR 308530..309219 (+) 690 WP_084828484.1 response regulator transcription factor Regulator
  STR1_RS01635 (STR1_01640) covS 309216..310733 (+) 1518 WP_084828485.1 HAMP domain-containing histidine kinase Regulator
  STR1_RS01640 (STR1_01645) nrdR 310855..311334 (+) 480 WP_002949642.1 transcriptional regulator NrdR -
  STR1_RS01645 (STR1_01650) - 311331..312506 (+) 1176 WP_095559236.1 DnaD domain protein -
  STR1_RS01650 (STR1_01655) dnaI 312510..313412 (+) 903 WP_014607971.1 primosomal protein DnaI -
  STR1_RS01655 (STR1_01660) der 313518..314828 (+) 1311 WP_095559237.1 ribosome biogenesis GTPase Der -
  STR1_RS01660 (STR1_01665) - 314892..315560 (+) 669 Protein_287 HI_0552 family protein -

Sequence

Protein


Download         Length: 505 a.a.        Molecular weight: 57568.03 Da        Isoelectric Point: 5.5179

>NTDB_id=510524 STR1_RS01635 WP_084828485.1 309216..310733(+) (covS) [Streptococcus thermophilus strain R1]
MSKLFGKVTIRKKLTMTTAVVFFLVLSMFTLVVVFSANTLLLQRERQNVNNTISKVVTYIEKDWDSDEELSPEPLLAAFY
SPKNIYPSIINGVLSEKRSLDGQVAVSNRLYSNQSVYVYDKKGTFIFTSEEDTDSPPGMSEVNKLKLVSYKGKRGFLLQV
PIYGKDKKTIVGYAQVFHDLKFYYALKERLIFLLIFLEVGMTVLVIAVIVVVLTSILRPMRQLHETMGIIIDSPSDLELR
SKIESHDEIGALALNFNCMMDKIQENNQMQMRFLSDVSHELRTPIAVIKGHMDLLQRWGKNDPEILEESLEAASHEANRM
TIMINDMLDSIRVKGSFDNHRNDTCDLNSSIRTVIGNFRVLHDDYQFYLNDSEGSDRPAQIYSQHFEQVITILIDNAVKY
SPVNKKIQVTIKALEDEMLVQVQDNGEGISKEDIEHIFERFYRSDKARNRTTTQSGVGIGLSILYQIVEAYRCHIDVSSE
LGVGTRFDLYIPFAESETTTPQIEG

Nucleotide


Download         Length: 1518 bp        

>NTDB_id=510524 STR1_RS01635 WP_084828485.1 309216..310733(+) (covS) [Streptococcus thermophilus strain R1]
ATGAGTAAATTATTTGGTAAAGTAACCATTAGAAAAAAGTTGACCATGACAACTGCTGTGGTCTTCTTTCTTGTATTGTC
GATGTTCACTCTGGTTGTTGTATTTTCAGCCAATACGCTTCTTTTGCAACGTGAACGTCAAAATGTAAATAATACAATCT
CAAAAGTTGTTACTTATATCGAAAAGGACTGGGACTCTGATGAAGAGTTGAGTCCAGAGCCGCTTTTAGCGGCCTTTTAT
TCACCGAAAAATATCTATCCATCAATCATTAATGGAGTGCTTTCTGAAAAGCGTTCCTTAGATGGTCAAGTTGCGGTTTC
TAATAGATTATATTCCAACCAGTCTGTCTATGTTTATGACAAAAAGGGAACTTTTATCTTTACTTCTGAGGAGGATACAG
ACTCACCTCCAGGCATGTCTGAGGTCAATAAACTGAAGTTGGTTTCCTATAAAGGTAAACGTGGTTTCTTACTACAAGTT
CCAATCTATGGCAAGGATAAGAAGACCATTGTTGGGTATGCTCAAGTTTTCCATGATTTGAAATTCTACTATGCGTTAAA
AGAGCGTTTAATTTTCCTATTGATATTCCTTGAAGTAGGAATGACGGTCTTAGTTATTGCAGTAATTGTAGTTGTCTTGA
CATCTATTCTTCGTCCGATGAGGCAGTTACACGAAACAATGGGTATTATTATCGATTCGCCAAGTGATTTGGAGCTTCGA
TCTAAGATTGAGAGTCATGATGAGATTGGTGCTTTGGCACTTAACTTTAACTGTATGATGGATAAAATTCAAGAAAATAA
TCAGATGCAGATGCGTTTCTTGAGTGACGTCAGTCACGAATTACGTACTCCCATTGCAGTTATTAAAGGACATATGGACC
TCTTGCAACGTTGGGGTAAAAATGATCCTGAAATCCTTGAAGAAAGTCTTGAAGCTGCAAGTCACGAAGCCAACCGTATG
ACGATTATGATTAACGATATGTTGGATTCTATTCGTGTTAAAGGGTCATTTGACAATCATAGAAATGATACATGTGATTT
GAATTCTTCAATCCGTACGGTTATTGGGAATTTCCGTGTCCTACATGACGACTACCAATTCTACCTCAATGATTCTGAGG
GTTCAGATCGTCCAGCACAGATTTACAGCCAGCACTTTGAACAGGTTATTACTATTTTGATTGATAATGCGGTCAAGTAT
TCGCCTGTTAATAAGAAAATCCAGGTTACTATCAAGGCTCTGGAAGATGAGATGCTGGTACAGGTACAGGATAATGGTGA
GGGTATCTCTAAAGAAGATATTGAACATATATTTGAACGCTTCTATCGTTCAGATAAGGCGCGTAATCGTACGACAACCC
AATCTGGTGTGGGTATTGGTTTATCAATCCTCTATCAAATTGTGGAAGCTTATCGATGCCATATCGATGTCAGTTCAGAA
CTTGGTGTGGGTACACGTTTTGACCTCTACATTCCTTTTGCAGAGTCAGAAACTACGACACCTCAAATTGAAGGTTAA

Domains

Predicted by InterproScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(384-494)

His Kinase A (phospho-acceptor) domain (HisKA)

(270-329)

ArlS sensor domain (ArlS_N)

(39-187)

HAMP domain (HAMP)

(213-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0E2Q5R4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covS Streptococcus salivarius strain HSISS4

94.223

99.406

0.937