Detailed information
Bioinformatically predicted
Overview
| Name | amiC | Type | Regulator |
| Locus tag | ST4052_RS06520 | Genome accession | NZ_CP065476 |
| Coordinates | 1256643..1258136 (-) | Length | 497 a.a. |
| NCBI ID | WP_011227407.1 | Uniprot ID | - |
| Organism | Streptococcus thermophilus strain 4052 | ||
| Function | internalize XIP (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 1238166..1306322 | 1256643..1258136 | within | 0 |
Gene organization within MGE regions
Location: 1238166..1306322
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ST4052_RS06430 (ST4052_06505) | liaF | 1238174..1238872 (-) | 699 | WP_011226289.1 | cell wall-active antibiotics response protein LiaF | - |
| ST4052_RS06435 | - | 1239138..1239293 (-) | 156 | WP_011226290.1 | ion channel | - |
| ST4052_RS06440 (ST4052_06515) | stkP/pknB | 1239930..1241801 (-) | 1872 | WP_011226292.1 | Stk1 family PASTA domain-containing Ser/Thr kinase | Regulator |
| ST4052_RS06445 (ST4052_06520) | - | 1241801..1242538 (-) | 738 | WP_002946881.1 | Stp1/IreP family PP2C-type Ser/Thr phosphatase | - |
| ST4052_RS06450 (ST4052_06525) | rsmB | 1242582..1243904 (-) | 1323 | WP_014608533.1 | 16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB | - |
| ST4052_RS06455 (ST4052_06530) | fmt | 1243894..1244829 (-) | 936 | WP_002951411.1 | methionyl-tRNA formyltransferase | - |
| ST4052_RS06460 (ST4052_06535) | - | 1244847..1247243 (-) | 2397 | WP_347100840.1 | primosomal protein N' | - |
| ST4052_RS06465 (ST4052_06540) | rpoZ | 1247385..1247699 (-) | 315 | WP_347100841.1 | DNA-directed RNA polymerase subunit omega | - |
| ST4052_RS06470 (ST4052_06545) | gmk | 1247721..1248350 (-) | 630 | WP_002951416.1 | guanylate kinase | - |
| ST4052_RS06475 (ST4052_06550) | ftsY | 1248583..1249974 (-) | 1392 | WP_347100842.1 | signal recognition particle-docking protein FtsY | - |
| ST4052_RS06480 (ST4052_06555) | - | 1249988..1250803 (-) | 816 | WP_011227405.1 | Cof-type HAD-IIB family hydrolase | - |
| ST4052_RS06485 (ST4052_06560) | - | 1250796..1251590 (-) | 795 | WP_059257398.1 | HAD family hydrolase | - |
| ST4052_RS06490 (ST4052_06565) | - | 1251773..1252150 (+) | 378 | WP_011226300.1 | GntR family transcriptional regulator | - |
| ST4052_RS06495 (ST4052_06570) | - | 1252155..1252853 (+) | 699 | WP_011226301.1 | ABC transporter ATP-binding protein | - |
| ST4052_RS06500 (ST4052_06575) | - | 1252865..1253650 (+) | 786 | WP_002951425.1 | hypothetical protein | - |
| ST4052_RS06505 (ST4052_06580) | amiF | 1253700..1254629 (-) | 930 | WP_002951426.1 | ATP-binding cassette domain-containing protein | Regulator |
| ST4052_RS06510 (ST4052_06585) | amiE | 1254622..1255707 (-) | 1086 | WP_011226304.1 | ABC transporter ATP-binding protein | Regulator |
| ST4052_RS06515 (ST4052_06590) | amiD | 1255717..1256643 (-) | 927 | WP_002946409.1 | oligopeptide ABC transporter permease OppC | Regulator |
| ST4052_RS06520 (ST4052_06595) | amiC | 1256643..1258136 (-) | 1494 | WP_011227407.1 | ABC transporter permease | Regulator |
| ST4052_RS06525 (ST4052_06600) | amiA | 1258198..1260165 (-) | 1968 | WP_347100844.1 | peptide ABC transporter substrate-binding protein | Regulator |
| ST4052_RS06530 (ST4052_06605) | - | 1260369..1260559 (-) | 191 | Protein_1231 | IS3 family transposase | - |
| ST4052_RS06535 | - | 1260553..1260954 (-) | 402 | Protein_1232 | ABC transporter ATP-binding protein | - |
| ST4052_RS06540 (ST4052_06620) | - | 1260949..1261309 (-) | 361 | Protein_1233 | TatD family hydrolase | - |
| ST4052_RS06545 (ST4052_06625) | - | 1261658..1262863 (+) | 1206 | WP_011227415.1 | OFA family MFS transporter | - |
| ST4052_RS06550 (ST4052_06630) | - | 1262909..1264261 (-) | 1353 | Protein_1235 | IS3 family transposase | - |
| ST4052_RS06555 (ST4052_06635) | pta | 1264347..1265330 (-) | 984 | WP_011227420.1 | phosphate acetyltransferase | - |
| ST4052_RS06560 (ST4052_06640) | - | 1265344..1266240 (-) | 897 | WP_011226316.1 | RluA family pseudouridine synthase | - |
| ST4052_RS06565 (ST4052_06645) | - | 1266237..1267073 (-) | 837 | WP_041827075.1 | NAD kinase | - |
| ST4052_RS06570 (ST4052_06650) | - | 1267045..1267719 (-) | 675 | WP_002951443.1 | GTP pyrophosphokinase family protein | - |
| ST4052_RS06575 (ST4052_06655) | - | 1267815..1268390 (+) | 576 | WP_002951444.1 | CYTH domain-containing protein | - |
| ST4052_RS06580 (ST4052_06660) | - | 1268753..1269724 (+) | 972 | WP_002951446.1 | ribose-phosphate diphosphokinase | - |
| ST4052_RS06585 (ST4052_06665) | - | 1269728..1270840 (+) | 1113 | WP_002948029.1 | cysteine desulfurase family protein | - |
| ST4052_RS06590 (ST4052_06670) | - | 1270842..1271189 (+) | 348 | WP_002948028.1 | DUF1831 domain-containing protein | - |
| ST4052_RS06595 (ST4052_06675) | - | 1271333..1271992 (+) | 660 | WP_041827076.1 | redox-sensing transcriptional repressor Rex | - |
| ST4052_RS06600 (ST4052_06680) | - | 1271985..1272680 (+) | 696 | WP_011227423.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| ST4052_RS06605 (ST4052_06685) | radC | 1272733..1273419 (-) | 687 | WP_011227424.1 | DNA repair protein RadC | - |
| ST4052_RS06610 (ST4052_06690) | - | 1273598..1274938 (-) | 1341 | WP_231108743.1 | DUF2142 domain-containing protein | - |
| ST4052_RS06615 (ST4052_06695) | - | 1275087..1276832 (-) | 1746 | WP_347100846.1 | rhamnan synthesis F family protein | - |
| ST4052_RS06620 (ST4052_06700) | - | 1276834..1278534 (-) | 1701 | WP_041827077.1 | glycosyltransferase family 4 protein | - |
| ST4052_RS06625 (ST4052_06705) | - | 1278552..1279754 (-) | 1203 | WP_059257395.1 | ABC transporter ATP-binding protein | - |
| ST4052_RS06630 (ST4052_06710) | - | 1279754..1280560 (-) | 807 | WP_011227429.1 | ABC transporter permease | - |
| ST4052_RS06635 (ST4052_06715) | - | 1280560..1281501 (-) | 942 | WP_011227430.1 | glycosyltransferase family 2 protein | - |
| ST4052_RS06640 (ST4052_06720) | - | 1281498..1282646 (-) | 1149 | WP_011227431.1 | glycosyltransferase family 1 protein | - |
| ST4052_RS06645 (ST4052_06725) | - | 1282765..1283547 (-) | 783 | WP_011227432.1 | glycosyltransferase family A protein | - |
| ST4052_RS06650 (ST4052_06730) | - | 1283548..1283880 (-) | 333 | WP_011227433.1 | DUF2304 domain-containing protein | - |
| ST4052_RS06655 (ST4052_06735) | - | 1283886..1284575 (-) | 690 | WP_011227434.1 | glycosyltransferase family 2 protein | - |
| ST4052_RS06660 (ST4052_06740) | - | 1284677..1285137 (-) | 461 | Protein_1257 | glycosyltransferase family 2 protein | - |
| ST4052_RS06665 (ST4052_06745) | - | 1285202..1286188 (-) | 987 | WP_011227437.1 | glycosyltransferase family 2 protein | - |
| ST4052_RS06670 (ST4052_06750) | - | 1286185..1287444 (-) | 1260 | WP_011227438.1 | lipopolysaccharide biosynthesis protein | - |
| ST4052_RS06675 (ST4052_06755) | rfbD | 1287565..1288416 (-) | 852 | WP_014621820.1 | dTDP-4-dehydrorhamnose reductase | - |
| ST4052_RS06680 (ST4052_06760) | - | 1288534..1289460 (-) | 927 | WP_347100848.1 | glycosyltransferase family 2 protein | - |
| ST4052_RS06685 (ST4052_06765) | - | 1289470..1289805 (-) | 336 | WP_002891474.1 | metal-sulfur cluster assembly factor | - |
| ST4052_RS06690 (ST4052_06770) | rpoD | 1289859..1290968 (-) | 1110 | WP_011227440.1 | RNA polymerase sigma factor RpoD | - |
| ST4052_RS06695 (ST4052_06775) | dnaG | 1290972..1292783 (-) | 1812 | WP_011227441.1 | DNA primase | - |
| ST4052_RS06700 (ST4052_06780) | rpsU | 1293155..1293331 (-) | 177 | WP_011226340.1 | 30S ribosomal protein S21 | - |
| ST4052_RS06705 (ST4052_06785) | - | 1293712..1294665 (+) | 954 | WP_041826943.1 | IS30 family transposase | - |
| ST4052_RS06710 (ST4052_06790) | - | 1294771..1295565 (-) | 795 | WP_011227442.1 | ABC transporter substrate-binding protein | - |
| ST4052_RS06715 (ST4052_06795) | - | 1295658..1296767 (-) | 1110 | WP_041828295.1 | aminotransferase | - |
| ST4052_RS06720 (ST4052_06800) | - | 1297114..1297911 (-) | 798 | WP_179966739.1 | transporter substrate-binding domain-containing protein | - |
| ST4052_RS06725 (ST4052_06805) | - | 1297908..1298738 (-) | 831 | WP_347100849.1 | transporter substrate-binding domain-containing protein | - |
| ST4052_RS06730 (ST4052_06810) | - | 1298952..1299416 (-) | 465 | WP_011226345.1 | 8-oxo-dGTP diphosphatase | - |
| ST4052_RS06735 (ST4052_06815) | uvrB | 1299461..1301452 (-) | 1992 | WP_002953358.1 | excinuclease ABC subunit UvrB | - |
| ST4052_RS06740 (ST4052_06820) | - | 1302139..1303075 (-) | 937 | Protein_1273 | type II CAAX endopeptidase family protein | - |
| ST4052_RS06745 (ST4052_06825) | - | 1303274..1305484 (+) | 2211 | WP_011226350.1 | ABC transporter substrate-binding protein/permease | - |
| ST4052_RS06750 (ST4052_06830) | - | 1305484..1306224 (+) | 741 | WP_002945131.1 | amino acid ABC transporter ATP-binding protein | - |
Sequence
Protein
Download Length: 497 a.a. Molecular weight: 55721.59 Da Isoelectric Point: 10.0618
>NTDB_id=509959 ST4052_RS06520 WP_011227407.1 1256643..1258136(-) (amiC) [Streptococcus thermophilus strain 4052]
MKKYILLRTLRSLLSIFVVTALTYTIIYTMVPRRLIFRQDPNYNKIAKTADSKANYENTIYERLGYIDYYDTKELQEKAS
SLDKSVTTKPTKENKAIYQKYVDSLGRGWRLHQFKQSKQFYATRDVPVLERVFGFYTHLFEFDNTGWVKDKTNPNLKRYI
RIENDPAIGWSVVGSGTKHKYLLYFNGQFPFVHQNFVKMNLGTSYPTYAEQGVLDVITQGQGQTKSSVVNFPTGKKISSV
DIYSRTYKSPSQADARDRSYYGNDPYTATKSRYQYPSMVTSSAIAGLIGLVLSYALAIPLGSYMALFKNTIFDSVSTGVL
TFLLSLPTIALVYIIRLIGSEIGLPDSFPILGAGDWRSYVLPSVILGLLSTPGLAIWIRRYMIDLQSQDFVRFARAKGLS
EQEISNKHILKNAMVSLVSGIPASIVGVITGATLTETIFAYPGMGKMLIDSVRASNNAMVVGLVFIFTALSIFSLLVGDI
LMTIIDPRIKLTSKGGK
MKKYILLRTLRSLLSIFVVTALTYTIIYTMVPRRLIFRQDPNYNKIAKTADSKANYENTIYERLGYIDYYDTKELQEKAS
SLDKSVTTKPTKENKAIYQKYVDSLGRGWRLHQFKQSKQFYATRDVPVLERVFGFYTHLFEFDNTGWVKDKTNPNLKRYI
RIENDPAIGWSVVGSGTKHKYLLYFNGQFPFVHQNFVKMNLGTSYPTYAEQGVLDVITQGQGQTKSSVVNFPTGKKISSV
DIYSRTYKSPSQADARDRSYYGNDPYTATKSRYQYPSMVTSSAIAGLIGLVLSYALAIPLGSYMALFKNTIFDSVSTGVL
TFLLSLPTIALVYIIRLIGSEIGLPDSFPILGAGDWRSYVLPSVILGLLSTPGLAIWIRRYMIDLQSQDFVRFARAKGLS
EQEISNKHILKNAMVSLVSGIPASIVGVITGATLTETIFAYPGMGKMLIDSVRASNNAMVVGLVFIFTALSIFSLLVGDI
LMTIIDPRIKLTSKGGK
Nucleotide
Download Length: 1494 bp
>NTDB_id=509959 ST4052_RS06520 WP_011227407.1 1256643..1258136(-) (amiC) [Streptococcus thermophilus strain 4052]
ATGAAAAAATACATTTTATTGAGAACACTCCGTTCTCTATTGTCAATATTTGTCGTGACGGCTTTGACCTACACGATTAT
CTATACCATGGTGCCGAGGCGTCTGATTTTCAGACAAGACCCGAACTACAACAAGATTGCTAAGACAGCTGATTCTAAGG
CTAACTATGAAAATACAATCTATGAACGCTTGGGTTACATTGATTACTATGACACCAAGGAGTTGCAGGAGAAAGCTAGC
TCCCTTGATAAGTCAGTAACCACTAAGCCAACAAAAGAAAATAAGGCTATCTACCAAAAATATGTGGATAGTTTAGGACG
TGGTTGGCGTTTGCATCAGTTCAAGCAAAGTAAACAATTCTATGCGACACGTGATGTGCCAGTGCTTGAACGTGTGTTTG
GCTTCTATACGCACCTCTTTGAATTTGACAATACTGGATGGGTTAAAGATAAAACAAATCCAAACTTGAAGCGTTATATC
CGTATTGAAAATGACCCAGCTATCGGTTGGTCAGTTGTTGGTTCAGGGACTAAGCATAAATATTTGCTTTACTTTAATGG
TCAGTTCCCATTTGTTCACCAAAACTTTGTGAAGATGAACCTTGGTACATCTTACCCAACTTATGCTGAGCAAGGTGTTC
TTGATGTTATTACACAAGGCCAAGGACAGACAAAAAGCTCTGTGGTTAACTTCCCTACTGGTAAGAAAATATCTTCAGTA
GATATCTACTCTCGTACTTATAAATCACCAAGTCAGGCTGACGCTAGAGATCGTTCTTACTATGGAAATGATCCATACAC
AGCTACCAAGAGTCGTTATCAATACCCATCAATGGTGACAAGTTCTGCCATTGCAGGTTTGATTGGTTTGGTCTTGTCTT
ATGCTTTGGCAATTCCATTGGGATCATACATGGCACTCTTTAAAAACACAATCTTTGATAGTGTGTCAACAGGTGTCTTG
ACTTTCTTGCTTTCACTACCAACCATCGCCTTGGTTTATATCATTCGTTTGATTGGTTCTGAGATTGGTCTTCCAGATTC
CTTCCCTATCTTGGGTGCAGGTGACTGGCGTTCATACGTCTTGCCATCTGTTATTCTCGGTCTCTTGTCAACACCAGGTC
TTGCGATTTGGATTCGTCGTTACATGATTGACTTGCAATCACAAGACTTCGTTCGTTTTGCACGTGCCAAAGGGTTGTCA
GAACAAGAAATTTCAAATAAACACATTTTAAAAAACGCTATGGTTTCCTTGGTTTCAGGGATCCCAGCATCTATTGTTGG
GGTTATCACAGGGGCAACCTTGACAGAAACAATCTTCGCCTACCCTGGTATGGGTAAAATGTTGATCGATTCTGTTCGTG
CTTCTAATAATGCTATGGTCGTTGGGCTGGTATTTATTTTTACAGCTCTCTCCATCTTCTCATTGCTTGTGGGTGATATC
CTTATGACTATTATTGACCCACGTATCAAATTGACATCTAAAGGAGGTAAATAA
ATGAAAAAATACATTTTATTGAGAACACTCCGTTCTCTATTGTCAATATTTGTCGTGACGGCTTTGACCTACACGATTAT
CTATACCATGGTGCCGAGGCGTCTGATTTTCAGACAAGACCCGAACTACAACAAGATTGCTAAGACAGCTGATTCTAAGG
CTAACTATGAAAATACAATCTATGAACGCTTGGGTTACATTGATTACTATGACACCAAGGAGTTGCAGGAGAAAGCTAGC
TCCCTTGATAAGTCAGTAACCACTAAGCCAACAAAAGAAAATAAGGCTATCTACCAAAAATATGTGGATAGTTTAGGACG
TGGTTGGCGTTTGCATCAGTTCAAGCAAAGTAAACAATTCTATGCGACACGTGATGTGCCAGTGCTTGAACGTGTGTTTG
GCTTCTATACGCACCTCTTTGAATTTGACAATACTGGATGGGTTAAAGATAAAACAAATCCAAACTTGAAGCGTTATATC
CGTATTGAAAATGACCCAGCTATCGGTTGGTCAGTTGTTGGTTCAGGGACTAAGCATAAATATTTGCTTTACTTTAATGG
TCAGTTCCCATTTGTTCACCAAAACTTTGTGAAGATGAACCTTGGTACATCTTACCCAACTTATGCTGAGCAAGGTGTTC
TTGATGTTATTACACAAGGCCAAGGACAGACAAAAAGCTCTGTGGTTAACTTCCCTACTGGTAAGAAAATATCTTCAGTA
GATATCTACTCTCGTACTTATAAATCACCAAGTCAGGCTGACGCTAGAGATCGTTCTTACTATGGAAATGATCCATACAC
AGCTACCAAGAGTCGTTATCAATACCCATCAATGGTGACAAGTTCTGCCATTGCAGGTTTGATTGGTTTGGTCTTGTCTT
ATGCTTTGGCAATTCCATTGGGATCATACATGGCACTCTTTAAAAACACAATCTTTGATAGTGTGTCAACAGGTGTCTTG
ACTTTCTTGCTTTCACTACCAACCATCGCCTTGGTTTATATCATTCGTTTGATTGGTTCTGAGATTGGTCTTCCAGATTC
CTTCCCTATCTTGGGTGCAGGTGACTGGCGTTCATACGTCTTGCCATCTGTTATTCTCGGTCTCTTGTCAACACCAGGTC
TTGCGATTTGGATTCGTCGTTACATGATTGACTTGCAATCACAAGACTTCGTTCGTTTTGCACGTGCCAAAGGGTTGTCA
GAACAAGAAATTTCAAATAAACACATTTTAAAAAACGCTATGGTTTCCTTGGTTTCAGGGATCCCAGCATCTATTGTTGG
GGTTATCACAGGGGCAACCTTGACAGAAACAATCTTCGCCTACCCTGGTATGGGTAAAATGTTGATCGATTCTGTTCGTG
CTTCTAATAATGCTATGGTCGTTGGGCTGGTATTTATTTTTACAGCTCTCTCCATCTTCTCATTGCTTGTGGGTGATATC
CTTATGACTATTATTGACCCACGTATCAAATTGACATCTAAAGGAGGTAAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| amiC | Streptococcus thermophilus LMG 18311 |
99.799 |
100 |
0.998 |
| amiC | Streptococcus thermophilus LMD-9 |
99.396 |
100 |
0.994 |
| amiC | Streptococcus salivarius strain HSISS4 |
97.183 |
100 |
0.972 |