Detailed information NTG0508803

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: I5046_RS09410
• Genome accession: NZ_CP065355
• Coordinates: 1930352..1931395 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain JW31330_O1_dhc
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1925352..1936395

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
I5046_RS09380 (I5046_09380)	-	1925773..1927029 (-)	1257	WP_078064589.1	aminopeptidase	-
I5046_RS09385 (I5046_09385)	-	1927032..1927232 (-)	201	WP_000180460.1	DUF1128 family protein	-
I5046_RS09390 (I5046_09390)	-	1927379..1927843 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
I5046_RS09395 (I5046_09395)	-	1927850..1928125 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
I5046_RS09400 (I5046_09400)	-	1928403..1929620 (+)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
I5046_RS09405 (I5046_09405)	vraR	1929733..1930362 (-)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
I5046_RS09410 (I5046_09410)	vraS	1930352..1931395 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
I5046_RS09415 (I5046_09415)	liaF	1931392..1932093 (-)	702	WP_196957488.1	cell wall-active antibiotics response protein LiaF	-
I5046_RS09420 (I5046_09420)	-	1932108..1932494 (-)	387	WP_001110179.1	hypothetical protein	-
I5046_RS09425 (I5046_09425)	map	1932711..1933469 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
I5046_RS09430 (I5046_09430)	-	1933881..1934867 (+)	987	WP_000999715.1	FUSC family protein	-
I5046_RS09435 (I5046_09435)	-	1935056..1935469 (-)	414	WP_025174552.1	hypothetical protein	-
I5046_RS09440 (I5046_09440)	-	1935498..1935608 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=508803 I5046_RS09410 WP_001017131.1 1930352..1931395(-) (vraS) [Staphylococcus aureus strain JW31330_O1_dhc]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=508803 I5046_RS09410 WP_001017131.1 1930352..1931395(-) (vraS) [Staphylococcus aureus strain JW31330_O1_dhc]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAACGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTCAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1