Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   SANR_RS10400 Genome accession   NC_022239
Coordinates   2127018..2128964 (-) Length   648 a.a.
NCBI ID   WP_020999879.1    Uniprot ID   -
Organism   Streptococcus anginosus C238     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 2122018..2133964
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SANR_RS10375 (SANR_2016) cinA 2122544..2123812 (-) 1269 WP_003038347.1 competence/damage-inducible protein A Machinery gene
  SANR_RS10380 (SANR_2017) - 2124453..2124824 (+) 372 WP_020999878.1 EamA family transporter -
  SANR_RS10385 (SANR_2018) - 2124933..2125505 (-) 573 WP_003038379.1 DNA-3-methyladenine glycosylase I -
  SANR_RS10390 (SANR_2019) ruvA 2125516..2126106 (-) 591 WP_003038332.1 Holliday junction branch migration protein RuvA Machinery gene
  SANR_RS10395 - 2126205..2126543 (+) 339 WP_003038373.1 hypothetical protein -
  SANR_RS10400 (SANR_2020) hexB 2127018..2128964 (-) 1947 WP_020999879.1 DNA mismatch repair endonuclease MutL Machinery gene
  SANR_RS10405 (SANR_2021) - 2129059..2130207 (-) 1149 WP_003038317.1 tyrosine-type recombinase/integrase -
  SANR_RS10410 (SANR_2022) - 2130364..2131368 (-) 1005 WP_020999880.1 virulence RhuM family protein -
  SANR_RS11355 (SANR_2023) - 2131513..2131989 (-) 477 WP_003038410.1 helix-turn-helix domain-containing protein -
  SANR_RS10420 (SANR_2024) - 2132151..2132348 (+) 198 WP_003038356.1 helix-turn-helix domain-containing protein -
  SANR_RS10425 (SANR_2025) - 2132365..2132982 (+) 618 WP_003038403.1 Rha family transcriptional regulator -
  SANR_RS11780 - 2132986..2133153 (+) 168 WP_003038324.1 hypothetical protein -
  SANR_RS10430 (SANR_2026) - 2133496..2133774 (+) 279 WP_003027794.1 hypothetical protein -
  SANR_RS11785 - 2133771..2133947 (+) 177 WP_003027795.1 hypothetical protein -

Sequence

Protein


Download         Length: 648 a.a.        Molecular weight: 73184.26 Da        Isoelectric Point: 5.0580

>NTDB_id=50787 SANR_RS10400 WP_020999879.1 2127018..2128964(-) (hexB) [Streptococcus anginosus C238]
MSKIIELPENLANQIAAGEVIERPSSVVKELIENSIDAGATQIIVEIEEAGLRSIQVIDNGEGIEHEEVSLALRRHATSK
IKKQADLFRIRTLGFRGEALPSIASVSRLTIETATSSGAHGTLLIAQGGEVETLDPSSCPRGTKIKVEDLFFNTPARLKY
MKSQQAELSHIVDVINRLSLAHPEVAFTLVNDGKEMTRTAGTGNLRQAIAGIYGLTTAKKMIEILASDLDFEVSGYISLP
ELTRANRNYITILINGRYIKNFLLNRAILDGYGSKLMVGRFPIAVIDIRIDPYLADVNVHPTKQEVRISKERELMALISQ
AIAVSLKEQDLIPDALENLAKSTINRAIKSEQTSLPLKENRLYYDKERNDFFVKPQVSEAQPSFEESARLDQQSADTDEL
NSKSASVKFAERQSPSYNQLDHPELDQASLERALDKLDGEETSTFPELEYFGQMHGTYLFAQGNGGLYIIDQHAAQERVK
YEYYREKIGDVDASQQQLLVPYIFEFPADDMLRLKQRMSLLEEAGVFLEEYGTNQFILREHPIWLKEEEIESGIYEMCDM
LLLTKEVSIKKYRAELAIMMSCKRSIKANHSLDDYSARDLIFQLSQCDNPYNCPHGRPVLVNFTKSDMEKMFRRIQENHT
SLRELGKY

Nucleotide


Download         Length: 1947 bp        

>NTDB_id=50787 SANR_RS10400 WP_020999879.1 2127018..2128964(-) (hexB) [Streptococcus anginosus C238]
ATGTCAAAAATTATTGAACTACCAGAAAATCTTGCTAATCAGATTGCAGCGGGTGAGGTTATTGAGCGACCTAGCAGCGT
TGTCAAGGAGTTAATAGAAAATTCTATTGATGCTGGTGCCACTCAGATTATAGTTGAGATTGAAGAAGCGGGACTCAGGA
GCATTCAAGTCATTGATAATGGTGAAGGAATTGAGCATGAGGAGGTTTCCTTGGCTTTGCGGCGGCATGCTACTAGTAAA
ATCAAGAAACAAGCCGACCTTTTTCGAATTCGGACATTGGGCTTTCGGGGCGAGGCGCTTCCATCCATTGCCTCTGTTTC
ACGTTTGACGATTGAAACTGCGACAAGTAGTGGTGCACATGGAACGCTTCTGATTGCGCAAGGTGGAGAAGTTGAGACTT
TAGATCCAAGTAGCTGTCCTAGGGGTACCAAAATCAAAGTGGAAGACCTTTTTTTCAACACGCCTGCTCGCTTGAAATAT
ATGAAAAGCCAACAAGCGGAACTATCTCATATTGTAGATGTGATTAACCGTTTAAGCTTGGCTCATCCGGAGGTCGCTTT
CACTCTTGTTAATGACGGTAAAGAGATGACACGGACAGCAGGAACAGGAAATCTGCGTCAAGCAATTGCTGGTATTTATG
GACTGACAACAGCCAAAAAAATGATTGAAATTTTAGCATCTGATTTGGATTTTGAAGTATCAGGCTATATTAGTTTGCCA
GAATTAACAAGGGCTAATCGGAATTACATTACTATCCTCATCAATGGTCGCTACATCAAGAATTTCCTACTCAATCGAGC
TATTTTAGATGGATATGGTAGCAAGCTCATGGTGGGACGTTTCCCGATTGCTGTGATTGATATTCGGATTGACCCATATC
TTGCTGATGTTAATGTTCACCCGACCAAGCAAGAAGTGCGGATTTCAAAGGAGCGAGAGCTCATGGCCTTGATATCGCAA
GCTATTGCTGTAAGTTTGAAAGAGCAAGATTTGATTCCGGACGCATTAGAGAATTTAGCCAAATCAACCATTAACCGAGC
AATTAAGTCTGAGCAGACCAGCCTCCCTCTCAAAGAGAACCGACTTTATTACGATAAAGAAAGAAATGACTTCTTTGTGA
AACCACAAGTGTCAGAAGCTCAACCTTCTTTTGAGGAATCTGCCCGATTAGACCAACAATCTGCTGATACAGATGAACTC
AATTCAAAATCTGCTTCTGTCAAATTTGCAGAAAGGCAATCTCCTTCTTACAATCAACTAGATCATCCAGAGCTGGATCA
GGCGAGCTTAGAGAGAGCTTTAGATAAGCTAGATGGAGAAGAAACTTCAACGTTTCCAGAATTGGAATATTTCGGGCAAA
TGCACGGCACCTACCTTTTTGCTCAAGGAAACGGTGGCCTTTATATTATTGACCAACATGCAGCTCAAGAGCGAGTAAAG
TACGAATATTACCGCGAAAAAATCGGAGATGTAGATGCTAGTCAGCAGCAGCTTCTGGTTCCCTATATTTTTGAATTTCC
AGCCGATGATATGCTGCGTCTGAAACAACGGATGTCTCTTTTAGAAGAAGCCGGTGTTTTCCTTGAAGAATACGGAACTA
ATCAATTTATTCTTCGTGAACATCCCATTTGGCTTAAGGAAGAGGAGATCGAATCAGGTATTTATGAGATGTGCGATATG
CTCCTTCTAACCAAGGAAGTCTCTATCAAGAAATATCGCGCTGAGCTGGCTATTATGATGAGTTGCAAACGCTCTATTAA
AGCCAATCACAGTTTGGATGACTATTCAGCGCGTGATTTGATCTTCCAGCTATCACAATGCGATAATCCCTACAACTGCC
CTCACGGTCGTCCCGTTTTGGTCAACTTCACCAAATCTGATATGGAAAAAATGTTCCGTCGGATTCAGGAAAATCATACC
AGCCTGAGAGAATTGGGGAAATATTAA

Domains

Predicted by InterProScan.

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-325)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-116)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

77.042

100

0.772

Multiple sequence alignment