Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   SANR_RS09370 Genome accession   NC_022239
Coordinates   1926114..1926854 (-) Length   246 a.a.
NCBI ID   WP_003038927.1    Uniprot ID   I0S511
Organism   Streptococcus anginosus C238     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1921114..1931854
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SANR_RS09350 (SANR_1814) - 1921203..1923317 (-) 2115 WP_020999825.1 GBS Bsp-like repeat-containing protein -
  SANR_RS09355 (SANR_1815) comD/blpH 1923726..1924550 (-) 825 WP_003037768.1 sensor histidine kinase Regulator
  SANR_RS09360 (SANR_1816) - 1924670..1925605 (-) 936 WP_020999450.1 IS30 family transposase -
  SANR_RS11655 - 1925682..1926092 (-) 411 WP_003038906.1 hypothetical protein -
  SANR_RS09370 (SANR_1817) comE/blpR 1926114..1926854 (-) 741 WP_003038927.1 response regulator transcription factor Regulator
  SANR_RS09375 (SANR_1818) - 1926986..1927624 (-) 639 WP_003038917.1 SGNH/GDSL hydrolase family protein -
  SANR_RS09380 (SANR_1819) - 1927624..1928454 (-) 831 WP_003038886.1 Cof-type HAD-IIB family hydrolase -
  SANR_RS09385 (SANR_1820) - 1928818..1929963 (+) 1146 WP_003038882.1 cobalamin-independent methionine synthase II family protein -
  SANR_RS09390 (SANR_1821) - 1930463..1930849 (-) 387 WP_003038936.1 VOC family protein -

Sequence

Protein


Download         Length: 246 a.a.        Molecular weight: 29319.85 Da        Isoelectric Point: 8.4284

>NTDB_id=50778 SANR_RS09370 WP_003038927.1 1926114..1926854(-) (comE/blpR) [Streptococcus anginosus C238]
MITIFVLEDDFVQQSRMERTIKEVMKKNSWKYRRIHIYGKPNQLLESITERGSHQLFFLDIQIKNESKRGFEIAEEIRRK
DPNATIVFVTTHSEFMPIIFQYKVAALDFIDKGLDERAFSRHVEEAINTVIEKQGRTVIEDSFNFETSLAMVQVPFHNIL
YFETSPTIHKVILHTKNERMEFYARISEIEKVDKRLYKCHQSYVVNLENILKVDKENGKVYFEDNEYCLVSRMRLKGLID
RIKKLQ

Nucleotide


Download         Length: 741 bp        

>NTDB_id=50778 SANR_RS09370 WP_003038927.1 1926114..1926854(-) (comE/blpR) [Streptococcus anginosus C238]
ATGATAACTATTTTTGTACTAGAAGATGATTTTGTACAACAATCTAGAATGGAGAGGACGATAAAAGAGGTTATGAAGAA
AAATTCTTGGAAATATCGTCGTATTCATATTTATGGGAAACCCAATCAACTACTTGAATCTATTACAGAAAGAGGTTCAC
ATCAACTTTTCTTTTTAGATATTCAAATAAAAAATGAATCAAAAAGAGGGTTTGAGATTGCAGAAGAAATTCGAAGAAAA
GATCCAAATGCAACAATTGTATTTGTAACAACCCATTCAGAATTTATGCCTATAATTTTTCAGTATAAAGTTGCGGCTCT
CGACTTTATTGATAAAGGATTAGATGAAAGAGCGTTTTCTAGACATGTTGAAGAAGCTATCAATACTGTGATAGAAAAGC
AAGGTCGTACAGTTATTGAAGATTCATTTAATTTTGAAACTTCATTAGCTATGGTCCAAGTGCCGTTTCATAATATTTTA
TATTTTGAAACATCGCCAACGATTCATAAAGTTATTTTACATACAAAAAATGAGAGAATGGAGTTTTATGCTCGTATTTC
AGAAATTGAAAAAGTAGATAAAAGACTTTATAAATGTCATCAATCTTATGTGGTAAATCTTGAAAATATTTTAAAAGTGG
ATAAAGAAAATGGTAAAGTATATTTTGAAGATAATGAATATTGTTTAGTATCAAGGATGAGATTAAAAGGGTTGATAGAT
AGAATAAAAAAACTTCAATAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-120)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0S511

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

52.282

97.967

0.512
  comE/comE1 Streptococcus equinus JB1

45.267

98.78

0.447
  comE/comE2 Streptococcus equinus JB1

39.837

100

0.398
  comE/comE2 Streptococcus gordonii strain NCTC7865

36.885

99.187

0.366
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

36.885

99.187

0.366

Multiple sequence alignment