Detailed information NTG0050677

Bioinformatically predicted

Overview

• Name: hexA
• Type: Machinery gene
• Locus tag: SCI_RS09495
• Genome accession: NC_022238
• Coordinates: 1897277..1899835 (-)
• Length: 852 a.a.
• NCBI ID: WP_020998099.1
• Uniprot ID: U2ZHI0
• Organism: Streptococcus constellatus subsp. pharyngis C1050
• Function: DNA mismatch repair (predicted from homology) Homologous recombination

Genomic Context

Location: 1892277..1904835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SCI_RS09470 (SCI_1847)	-	1892498..1893061 (-)	564	WP_006269031.1	DNA-3-methyladenine glycosylase I	-
SCI_RS09475 (SCI_1848)	ruvA	1893072..1893662 (-)	591	WP_006269179.1	Holliday junction branch migration protein RuvA	Machinery gene
SCI_RS09480 (SCI_1849)	hexB	1894048..1895994 (-)	1947	WP_020998097.1	DNA mismatch repair endonuclease MutL	Machinery gene
SCI_RS09485 (SCI_1850)	-	1896253..1896681 (+)	429	WP_006269102.1	LytTR family DNA-binding domain-containing protein	-
SCI_RS09490 (SCI_1851)	-	1896678..1897136 (+)	459	WP_020998098.1	DUF3021 domain-containing protein	-
SCI_RS09495 (SCI_1852)	hexA	1897277..1899835 (-)	2559	WP_020998099.1	DNA mismatch repair protein MutS	Machinery gene
SCI_RS09500 (SCI_1853)	argR	1899998..1900438 (-)	441	WP_003071513.1	arginine repressor	-
SCI_RS09505 (SCI_1854)	argS	1900542..1902230 (+)	1689	WP_003071514.1	arginine--tRNA ligase	-
SCI_RS09510 (SCI_1855)	nrdI	1902282..1902737 (-)	456	WP_006268956.1	class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI	-
SCI_RS09515 (SCI_1856)	-	1902813..1903322 (-)	510	WP_020998100.1	hypothetical protein	-

Sequence

Protein

• Length: 852 a.a.
• Molecular weight: 95972.41 Da
• Isoelectric Point: 4.9979

>NTDB_id=50677 SCI_RS09495 WP_020998099.1 1897277..1899835(-) (hexA) [Streptococcus constellatus subsp. pharyngis C1050]
MTKEKLSPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAINAAQILEIALTSRNKNSENPIPMAGVPYHSVQQYIDVLI
ESGYKVAIAEQVEDPKKAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVALDKLENLYGLAYMDLVTGEFQVTSLSDFNM
VCGEIRNLRAREVVLGYELPESEHQVLANQMNLLLSQVGTAFEDVQLLGDELSRLEHQVAGKLLEYVHQTQLRELSHLKR
VHHYEIKDFLQMDYATMASLDLTENARTGKKHGSLYWLMDETKTAMGTRLLRRWIQQPLIDKERILKRQDVVQVFLDHFF
ERSDLADSLKGVYDIERLASRVSFGKTNPKDLLQLAATLSNVPQIKGILQGIDHPVLGQLIENLDDIPELANLIQSAISP
DAPNVITEGNIIQTGFDETLDKYRVVMRDGTSWIADIEAKERAASGINNLKIDYNKKDGYYFHVTNSQLEHVPSHFFRKA
TLKNSERFGTEELARIEGEMLEAREKSANLEYEIFMRIREEAGKYIKRLQSLAQTLATIDVLQSFAAVAEKQRFVRPEFI
ERPSIEIDKGRHAVVEKVMGAQTYIPNSISMDENVNVQLITGPNMSGKSTYMRQLAIIVIMAQMGSYVSAESAQLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANHAISQATEHSLILFDELGRGTATYDGMALAQAIIEYIHNRTGAKTLFATHYHEL
TDLSTSLTQLENVHVATLEKDGQVTFLHKIEAGPADKSYGIHVAKIAGLPNDLLMRADQILTRLEEQANEKPSLNPSNKG
ANDSKENQVSEQISLFTETTESPVLEKLRQLDIYNMTPMEVMLAVAEMKKHL

Nucleotide

• Length: 2559 bp

>NTDB_id=50677 SCI_RS09495 WP_020998099.1 1897277..1899835(-) (hexA) [Streptococcus constellatus subsp. pharyngis C1050]
ATGACAAAAGAAAAACTATCTCCGGGAATGCAACAGTATTTAGATATAAAAAAAGATTATCCGGATGCTTTTTTGCTATT
TCGCATGGGAGATTTTTATGAATTATTCTATGAAGATGCGATCAATGCAGCACAGATTTTAGAAATTGCTCTGACTAGCC
GTAATAAAAATTCGGAAAATCCAATCCCGATGGCAGGAGTTCCCTACCATTCGGTGCAACAGTATATTGATGTTTTAATT
GAATCGGGCTATAAAGTAGCGATTGCAGAGCAGGTGGAAGATCCTAAAAAAGCAGTTGGTGTAGTCAAACGTGAGGTGGT
ACAAGTCATCACACCGGGGACAGTCGTTGATTCTTCAAAACCAGATAGTCAAAATAATTTCTTGGTAGCTTTAGATAAAC
TAGAAAATTTATATGGGCTGGCTTACATGGACTTGGTTACAGGTGAATTTCAGGTCACAAGTCTTAGTGACTTTAACATG
GTCTGTGGAGAAATTCGGAACTTGCGAGCGCGTGAAGTGGTCTTAGGATATGAATTACCTGAATCAGAGCACCAAGTGTT
GGCAAATCAAATGAATTTGTTATTATCACAGGTGGGAACTGCTTTTGAAGATGTTCAGCTATTAGGGGATGAATTGTCTC
GCTTAGAACATCAAGTAGCTGGAAAACTGTTAGAATATGTTCATCAGACGCAGCTGCGTGAGCTTAGTCACTTAAAGCGA
GTTCATCATTATGAAATCAAGGATTTCTTACAGATGGATTATGCAACCATGGCAAGTCTGGATTTAACAGAGAATGCACG
TACAGGAAAGAAGCACGGTAGTCTGTATTGGCTGATGGATGAGACCAAGACAGCTATGGGAACGCGACTTTTAAGAAGAT
GGATTCAGCAGCCCTTGATTGACAAAGAGCGAATCCTTAAGCGGCAGGATGTCGTACAAGTCTTTTTAGATCATTTTTTT
GAGCGCAGTGATTTAGCAGATAGTCTCAAAGGTGTGTATGACATTGAGCGTTTAGCTAGTCGTGTTTCGTTTGGAAAGAC
CAATCCGAAAGATTTATTGCAGTTGGCGGCAACATTGAGCAATGTCCCTCAGATTAAGGGAATTTTACAAGGAATTGATC
ATCCTGTTTTGGGACAGTTGATTGAAAACTTGGATGACATTCCAGAATTGGCAAACTTGATTCAGTCGGCGATTTCTCCC
GATGCTCCAAATGTTATTACTGAAGGGAATATCATTCAAACTGGTTTTGATGAAACCTTAGATAAGTATCGAGTGGTTAT
GCGAGATGGTACGAGCTGGATTGCTGATATCGAAGCGAAAGAAAGGGCGGCTAGTGGGATTAATAATCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTCCATGTCACTAATTCACAGTTGGAGCACGTACCTAGCCACTTTTTCCGAAAAGCA
ACGTTGAAAAATTCAGAACGATTTGGTACAGAGGAATTGGCTCGTATTGAAGGCGAAATGTTGGAAGCGCGTGAAAAATC
TGCTAATTTAGAATATGAGATTTTTATGCGTATTCGTGAAGAAGCTGGCAAATATATCAAGCGTCTGCAATCCTTGGCAC
AAACTCTGGCAACGATTGATGTATTACAAAGTTTTGCAGCAGTTGCTGAAAAGCAACGCTTTGTACGCCCAGAATTTATT
GAACGTCCTTCCATTGAAATTGATAAGGGACGGCATGCGGTTGTAGAAAAGGTCATGGGTGCACAAACCTATATTCCTAA
CAGCATTTCAATGGATGAAAATGTCAACGTTCAGCTAATTACAGGTCCAAATATGAGTGGGAAGTCAACCTATATGCGTC
AATTAGCGATTATTGTTATTATGGCTCAAATGGGTTCCTATGTTTCAGCTGAGAGTGCTCAATTACCAATTTTTGATGCC
ATCTTCACTCGAATTGGTGCGGCAGATGACTTGGTATCTGGACAATCAACCTTTATGGTAGAAATGATGGAAGCAAATCA
TGCTATTTCTCAAGCAACAGAGCACTCTCTTATTCTTTTTGATGAGTTGGGAAGAGGGACAGCGACATATGATGGGATGG
CTCTTGCTCAGGCGATTATTGAATATATCCACAATCGAACAGGGGCAAAGACTCTTTTTGCCACACACTATCATGAGTTG
ACAGACTTGTCAACTAGCTTGACACAGTTAGAAAATGTTCATGTAGCAACTTTAGAAAAAGATGGGCAAGTGACCTTCCT
TCATAAGATTGAAGCTGGTCCTGCGGATAAATCTTATGGGATTCATGTGGCAAAAATTGCAGGTTTACCGAATGATTTGC
TGATGAGAGCAGACCAGATCTTAACACGATTAGAAGAACAAGCAAATGAGAAACCGTCTCTCAATCCTTCTAATAAAGGA
GCTAATGATAGTAAGGAAAATCAAGTATCTGAGCAGATATCTTTATTCACAGAAACAACTGAATCCCCTGTTTTAGAAAA
GTTACGTCAGTTGGACATCTACAACATGACCCCAATGGAAGTGATGCTAGCTGTAGCTGAGATGAAAAAACATCTCTGA

Domains

Predicted by InterProScan.

• MutS domain III (MutS_III) (255-546)

• MutS domain I (MutS_I) (8-118)

• MutS domain II (MutS_II) (126-239)

• MutS domain V (MutS_V) (599-785)

• MutS family domain IV (MutS_IV) (415-505)

3D structure

• AlphaFold DB: U2ZHI0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
hexA	Streptococcus pneumoniae R6	76.174	100	0.762
mutS	Pseudomonas stutzeri strain ATCC 17587	37.037	100	0.376