Detailed information
Bioinformatically predicted
Overview
| Name | clpX | Type | Regulator |
| Locus tag | I2437_RS04420 | Genome accession | NZ_CP065061 |
| Coordinates | 902231..903460 (+) | Length | 409 a.a. |
| NCBI ID | WP_138119364.1 | Uniprot ID | - |
| Organism | Streptococcus equi subsp. zooepidemicus strain SEZ33 | ||
| Function | require for competence development (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 870165..952944 | 902231..903460 | within | 0 |
Gene organization within MGE regions
Location: 870165..952944
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I2437_RS04285 (IEMOCGPF_00853) | - | 870165..870764 (+) | 600 | WP_115251008.1 | glycoside hydrolase family 73 protein | - |
| I2437_RS04290 (IEMOCGPF_00854) | - | 871327..871536 (+) | 210 | WP_037580961.1 | helix-turn-helix transcriptional regulator | - |
| I2437_RS04295 (IEMOCGPF_00855) | - | 871526..871909 (+) | 384 | WP_115251007.1 | DUF2178 domain-containing protein | - |
| I2437_RS04300 (IEMOCGPF_00857) | - | 872368..872598 (+) | 231 | WP_014622960.1 | hypothetical protein | - |
| I2437_RS09625 | - | 872689..872892 (+) | 204 | Protein_783 | conjugal transfer protein TraA | - |
| I2437_RS04305 (IEMOCGPF_00858) | - | 873006..874364 (+) | 1359 | WP_165627706.1 | SLC13 family permease | - |
| I2437_RS04315 (IEMOCGPF_00861) | - | 876246..876959 (+) | 714 | WP_115251006.1 | glycoside hydrolase family 73 protein | - |
| I2437_RS04320 (IEMOCGPF_00862) | - | 877187..877567 (+) | 381 | WP_037580974.1 | DUF1149 family protein | - |
| I2437_RS04325 (IEMOCGPF_00863) | - | 877567..878415 (+) | 849 | WP_043030854.1 | DegV family protein | - |
| I2437_RS04330 (IEMOCGPF_00864) | - | 878515..879726 (+) | 1212 | WP_043030860.1 | CCA tRNA nucleotidyltransferase | - |
| I2437_RS04335 (IEMOCGPF_00865) | - | 879719..881587 (+) | 1869 | WP_043053141.1 | ABC-F family ATP-binding cassette domain-containing protein | - |
| I2437_RS04340 (IEMOCGPF_00866) | - | 881692..883437 (+) | 1746 | WP_206157997.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04345 (IEMOCGPF_00867) | - | 883437..885209 (+) | 1773 | WP_206157998.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04350 (IEMOCGPF_00868) | gdhA | 885350..886699 (+) | 1350 | WP_115251000.1 | NADP-specific glutamate dehydrogenase | - |
| I2437_RS04355 (IEMOCGPF_00869) | - | 886829..887239 (+) | 411 | WP_042670730.1 | peptide deformylase | - |
| I2437_RS04360 (IEMOCGPF_00870) | - | 887431..889437 (-) | 2007 | WP_115250999.1 | 5'-nucleotidase C-terminal domain-containing protein | - |
| I2437_RS04365 (IEMOCGPF_00871) | - | 889888..891609 (+) | 1722 | WP_165627749.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04370 (IEMOCGPF_00872) | - | 891611..893362 (+) | 1752 | WP_111678177.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04375 (IEMOCGPF_00873) | mvk | 893893..894771 (+) | 879 | WP_165627711.1 | mevalonate kinase | - |
| I2437_RS04380 (IEMOCGPF_00874) | mvaD | 894753..895697 (+) | 945 | WP_043039013.1 | diphosphomevalonate decarboxylase | - |
| I2437_RS04385 (IEMOCGPF_00875) | - | 895690..896688 (+) | 999 | WP_115266871.1 | phosphomevalonate kinase | - |
| I2437_RS04390 (IEMOCGPF_00876) | fni | 896691..897683 (+) | 993 | WP_165627712.1 | type 2 isopentenyl-diphosphate Delta-isomerase | - |
| I2437_RS04395 (IEMOCGPF_00877) | - | 897958..899241 (-) | 1284 | WP_206158030.1 | hydroxymethylglutaryl-CoA reductase, degradative | - |
| I2437_RS04400 (IEMOCGPF_00878) | - | 899228..900403 (-) | 1176 | WP_165627714.1 | hydroxymethylglutaryl-CoA synthase | - |
| I2437_RS04405 (IEMOCGPF_00879) | - | 900588..901427 (+) | 840 | WP_165626051.1 | thymidylate synthase | - |
| I2437_RS04410 (IEMOCGPF_00880) | - | 901508..902005 (+) | 498 | WP_165627715.1 | dihydrofolate reductase | - |
| I2437_RS04415 (IEMOCGPF_00881) | - | 902025..902195 (+) | 171 | WP_012515696.1 | hypothetical protein | - |
| I2437_RS04420 (IEMOCGPF_00882) | clpX | 902231..903460 (+) | 1230 | WP_138119364.1 | ATP-dependent Clp protease ATP-binding subunit ClpX | Regulator |
| I2437_RS04425 (IEMOCGPF_00883) | yihA | 903470..904069 (+) | 600 | WP_012677890.1 | ribosome biogenesis GTP-binding protein YihA/YsxC | - |
| I2437_RS04430 (IEMOCGPF_00884) | - | 904431..907433 (+) | 3003 | WP_206157999.1 | leucine-rich repeat domain-containing protein | - |
| I2437_RS04435 (IEMOCGPF_00885) | clpC | 907622..909715 (-) | 2094 | WP_206158000.1 | ATP-dependent Clp protease ATP-binding subunit | Regulator |
| I2437_RS04440 (IEMOCGPF_00886) | ndk | 910086..910505 (+) | 420 | WP_206158001.1 | nucleoside-diphosphate kinase | - |
| I2437_RS04445 (IEMOCGPF_00887) | - | 911006..911812 (+) | 807 | WP_165627718.1 | DNA/RNA non-specific endonuclease | - |
| I2437_RS04450 (IEMOCGPF_00888) | - | 912114..913079 (-) | 966 | WP_012679526.1 | polysaccharide deacetylase family protein | - |
| I2437_RS04455 (IEMOCGPF_00889) | - | 913251..914534 (+) | 1284 | WP_165627719.1 | homoserine dehydrogenase | - |
| I2437_RS04460 (IEMOCGPF_00890) | thrB | 914536..915396 (+) | 861 | WP_138119358.1 | homoserine kinase | - |
| I2437_RS04465 (IEMOCGPF_00891) | - | 915561..916820 (+) | 1260 | WP_165627721.1 | folylpolyglutamate synthase/dihydrofolate synthase family protein | - |
| I2437_RS04470 (IEMOCGPF_00892) | folE | 916877..917443 (+) | 567 | WP_012515684.1 | GTP cyclohydrolase I FolE | - |
| I2437_RS04475 (IEMOCGPF_00893) | folP | 917451..918251 (+) | 801 | WP_043039002.1 | dihydropteroate synthase | - |
| I2437_RS04480 (IEMOCGPF_00894) | folB | 918258..918617 (+) | 360 | WP_012679532.1 | dihydroneopterin aldolase | - |
| I2437_RS04485 (IEMOCGPF_00895) | folK | 918614..919120 (+) | 507 | WP_165627723.1 | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase | - |
| I2437_RS04490 (IEMOCGPF_00896) | murB | 919216..920103 (+) | 888 | WP_043029764.1 | UDP-N-acetylmuramate dehydrogenase | - |
| I2437_RS04495 (IEMOCGPF_00897) | - | 920149..921303 (+) | 1155 | WP_165627725.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04500 (IEMOCGPF_00898) | - | 921287..922081 (+) | 795 | WP_165627726.1 | ABC transporter permease | - |
| I2437_RS04505 (IEMOCGPF_00899) | - | 922078..922854 (+) | 777 | WP_165627727.1 | ABC transporter permease | - |
| I2437_RS04510 (IEMOCGPF_00900) | - | 922847..923920 (+) | 1074 | WP_165627728.1 | ABC transporter substrate-binding protein | - |
| I2437_RS04515 (IEMOCGPF_00901) | - | 924078..925610 (+) | 1533 | WP_165627729.1 | ClC family H(+)/Cl(-) exchange transporter | - |
| I2437_RS04520 (IEMOCGPF_00902) | - | 925815..926429 (+) | 615 | WP_014622917.1 | SGNH/GDSL hydrolase family protein | - |
| I2437_RS04525 (IEMOCGPF_00903) | - | 926788..927915 (+) | 1128 | WP_012515673.1 | AI-2E family transporter | - |
| I2437_RS04530 (IEMOCGPF_00904) | radC | 928082..928759 (+) | 678 | WP_021320801.1 | DNA repair protein RadC | - |
| I2437_RS04535 (IEMOCGPF_00905) | - | 928761..929456 (-) | 696 | WP_037584180.1 | gamma-glutamyl-gamma-aminobutyrate hydrolase family protein | - |
| I2437_RS04540 (IEMOCGPF_00906) | - | 929468..930112 (-) | 645 | WP_012677911.1 | redox-sensing transcriptional repressor Rex | - |
| I2437_RS04545 (IEMOCGPF_00907) | - | 930398..930745 (-) | 348 | WP_012515669.1 | DUF1831 domain-containing protein | - |
| I2437_RS04550 (IEMOCGPF_00908) | - | 930735..931862 (-) | 1128 | WP_206158002.1 | cysteine desulfurase family protein | - |
| I2437_RS04555 (IEMOCGPF_00909) | - | 931865..932839 (-) | 975 | WP_165627731.1 | ribose-phosphate diphosphokinase | - |
| I2437_RS04560 (IEMOCGPF_00910) | - | 932974..933546 (-) | 573 | WP_012515666.1 | CYTH domain-containing protein | - |
| I2437_RS04565 (IEMOCGPF_00911) | - | 933641..934312 (+) | 672 | WP_012677913.1 | GTP pyrophosphokinase family protein | - |
| I2437_RS04570 (IEMOCGPF_00912) | - | 934287..935123 (+) | 837 | WP_021320798.1 | NAD kinase | - |
| I2437_RS04575 (IEMOCGPF_00913) | - | 935120..936022 (+) | 903 | WP_165627732.1 | RluA family pseudouridine synthase | - |
| I2437_RS04580 (IEMOCGPF_00914) | pta | 936026..937027 (+) | 1002 | WP_165627733.1 | phosphate acetyltransferase | - |
| I2437_RS04585 (IEMOCGPF_00915) | - | 937127..937885 (+) | 759 | WP_165627734.1 | SDR family NAD(P)-dependent oxidoreductase | - |
| I2437_RS04590 (IEMOCGPF_00916) | - | 937989..938675 (-) | 687 | WP_165627735.1 | multidrug transporter | - |
| I2437_RS04595 (IEMOCGPF_00917) | - | 938919..939647 (+) | 729 | WP_012677918.1 | ABC transporter ATP-binding protein | - |
| I2437_RS04600 (IEMOCGPF_00918) | - | 939640..941172 (+) | 1533 | WP_206158003.1 | ABC transporter permease/substrate-binding protein | - |
| I2437_RS04605 (IEMOCGPF_00919) | guaC | 941531..942514 (+) | 984 | WP_111678155.1 | GMP reductase | - |
| I2437_RS04610 (IEMOCGPF_00920) | - | 942700..943281 (+) | 582 | WP_021320794.1 | xanthine phosphoribosyltransferase | - |
| I2437_RS04615 (IEMOCGPF_00921) | - | 943556..944497 (-) | 942 | WP_206158004.1 | FAD:protein FMN transferase | - |
| I2437_RS04620 (IEMOCGPF_00922) | - | 944552..944737 (-) | 186 | WP_012515655.1 | 4-oxalocrotonate tautomerase | - |
| I2437_RS04625 (IEMOCGPF_00923) | - | 944924..945493 (+) | 570 | WP_164335532.1 | thymidine kinase | - |
| I2437_RS04630 (IEMOCGPF_00924) | prfA | 945536..946618 (+) | 1083 | WP_165627738.1 | peptide chain release factor 1 | - |
| I2437_RS04635 (IEMOCGPF_00925) | prmC | 946615..947463 (+) | 849 | WP_126436725.1 | peptide chain release factor N(5)-glutamine methyltransferase | - |
| I2437_RS04640 (IEMOCGPF_00926) | - | 947435..948028 (+) | 594 | WP_126436723.1 | L-threonylcarbamoyladenylate synthase | - |
| I2437_RS04645 (IEMOCGPF_00927) | - | 948042..948473 (+) | 432 | WP_043053102.1 | GNAT family N-acetyltransferase | - |
| I2437_RS04650 (IEMOCGPF_00928) | glyA | 948485..949744 (+) | 1260 | WP_165627740.1 | serine hydroxymethyltransferase | - |
| I2437_RS04655 (IEMOCGPF_00929) | - | 949747..950724 (+) | 978 | WP_043029741.1 | nucleoid-associated protein | - |
| I2437_RS04660 (IEMOCGPF_00930) | - | 950725..951327 (+) | 603 | WP_206158005.1 | lysozyme family protein | - |
| I2437_RS04665 (IEMOCGPF_00931) | - | 951577..952944 (+) | 1368 | WP_012677930.1 | FAD-dependent oxidoreductase | - |
Sequence
Protein
Download Length: 409 a.a. Molecular weight: 45186.66 Da Isoelectric Point: 4.5726
>NTDB_id=506603 I2437_RS04420 WP_138119364.1 902231..903460(+) (clpX) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
MAGNRSNDIKVHCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEILNQYVIGQER
AKRALSVAVYNHYKRISFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKIIGFGQNSRKIDDNASYMQEINAEDIQKFGLIPEFIGRLPVVAALEQLNTEDLIRI
LTEPRNALVKQYQALLSYDGVELEFEKGALEAIAGRAIERKTGARGLRSIIEETMLDIMFEVPSQEEVTKVRITKEAVEG
QSKPILEIA
MAGNRSNDIKVHCSFCGKSQDEVKKIIAGNNVFICNECVALSQEIIKEELAEEVLADLTEVPKPKELLEILNQYVIGQER
AKRALSVAVYNHYKRISFTESRDDDDVDLQKSNILMIGPTGSGKTFLAQTLAKSLNVPFAIADATSLTEAGYVGEDVENI
LLKLIQAADYNVERAERGIIYVDEIDKIAKKGENVSITRDVSGEGVQQALLKIIEGTVASVPPQGGRKHPNQEMIQIDTK
NILFIVGGAFDGIEEIVKQRLGEKIIGFGQNSRKIDDNASYMQEINAEDIQKFGLIPEFIGRLPVVAALEQLNTEDLIRI
LTEPRNALVKQYQALLSYDGVELEFEKGALEAIAGRAIERKTGARGLRSIIEETMLDIMFEVPSQEEVTKVRITKEAVEG
QSKPILEIA
Nucleotide
Download Length: 1230 bp
>NTDB_id=506603 I2437_RS04420 WP_138119364.1 902231..903460(+) (clpX) [Streptococcus equi subsp. zooepidemicus strain SEZ33]
ATGGCAGGAAATCGTAGTAACGATATTAAGGTTCATTGCTCGTTTTGCGGCAAGAGCCAAGACGAAGTGAAAAAAATTAT
TGCAGGTAATAACGTCTTTATTTGTAACGAATGTGTTGCCTTATCACAAGAAATCATCAAGGAAGAATTGGCAGAAGAGG
TTCTCGCTGATCTGACTGAGGTACCAAAGCCAAAAGAGCTGCTTGAGATTTTAAATCAATACGTCATTGGGCAGGAGCGT
GCTAAGAGAGCCTTATCAGTTGCAGTTTACAACCACTACAAGAGGATTTCATTTACTGAGAGTCGTGACGATGATGATGT
GGATTTGCAAAAGTCAAACATTCTGATGATTGGACCAACAGGCTCAGGAAAAACCTTTTTGGCACAGACCCTAGCTAAGA
GTTTGAATGTTCCGTTTGCTATTGCTGATGCAACCTCTTTGACTGAAGCAGGCTATGTCGGAGAGGATGTGGAAAATATC
CTTCTGAAATTAATTCAAGCCGCTGATTACAATGTTGAACGTGCAGAGCGCGGCATTATTTATGTTGACGAAATTGATAA
AATCGCTAAAAAGGGTGAAAATGTCTCTATCACTCGTGACGTATCAGGAGAGGGTGTCCAGCAAGCTTTGCTAAAAATCA
TTGAAGGAACGGTTGCCAGTGTTCCACCACAGGGTGGTCGTAAGCACCCAAACCAAGAGATGATACAGATTGATACCAAA
AATATCTTGTTTATCGTCGGAGGCGCTTTTGATGGTATCGAAGAAATTGTCAAGCAGCGCTTGGGAGAAAAGATCATTGG
CTTTGGGCAAAATAGTCGAAAGATTGATGACAATGCTTCCTATATGCAGGAGATCAATGCTGAGGATATTCAAAAATTTG
GTCTGATTCCTGAATTTATTGGACGCTTGCCTGTTGTGGCAGCGCTTGAGCAGCTTAATACTGAGGATTTGATTCGTATT
TTAACAGAGCCTAGAAATGCCCTTGTGAAGCAATATCAAGCCTTGCTGTCATATGATGGCGTAGAGCTTGAGTTTGAAAA
GGGAGCTCTGGAAGCTATTGCAGGCAGAGCTATTGAGCGCAAGACTGGTGCGCGTGGTCTGAGGTCTATTATCGAAGAAA
CCATGCTGGATATCATGTTTGAGGTGCCAAGCCAAGAGGAAGTAACCAAGGTACGCATTACTAAGGAAGCTGTCGAAGGT
CAATCAAAGCCTATTTTAGAGATAGCCTAA
ATGGCAGGAAATCGTAGTAACGATATTAAGGTTCATTGCTCGTTTTGCGGCAAGAGCCAAGACGAAGTGAAAAAAATTAT
TGCAGGTAATAACGTCTTTATTTGTAACGAATGTGTTGCCTTATCACAAGAAATCATCAAGGAAGAATTGGCAGAAGAGG
TTCTCGCTGATCTGACTGAGGTACCAAAGCCAAAAGAGCTGCTTGAGATTTTAAATCAATACGTCATTGGGCAGGAGCGT
GCTAAGAGAGCCTTATCAGTTGCAGTTTACAACCACTACAAGAGGATTTCATTTACTGAGAGTCGTGACGATGATGATGT
GGATTTGCAAAAGTCAAACATTCTGATGATTGGACCAACAGGCTCAGGAAAAACCTTTTTGGCACAGACCCTAGCTAAGA
GTTTGAATGTTCCGTTTGCTATTGCTGATGCAACCTCTTTGACTGAAGCAGGCTATGTCGGAGAGGATGTGGAAAATATC
CTTCTGAAATTAATTCAAGCCGCTGATTACAATGTTGAACGTGCAGAGCGCGGCATTATTTATGTTGACGAAATTGATAA
AATCGCTAAAAAGGGTGAAAATGTCTCTATCACTCGTGACGTATCAGGAGAGGGTGTCCAGCAAGCTTTGCTAAAAATCA
TTGAAGGAACGGTTGCCAGTGTTCCACCACAGGGTGGTCGTAAGCACCCAAACCAAGAGATGATACAGATTGATACCAAA
AATATCTTGTTTATCGTCGGAGGCGCTTTTGATGGTATCGAAGAAATTGTCAAGCAGCGCTTGGGAGAAAAGATCATTGG
CTTTGGGCAAAATAGTCGAAAGATTGATGACAATGCTTCCTATATGCAGGAGATCAATGCTGAGGATATTCAAAAATTTG
GTCTGATTCCTGAATTTATTGGACGCTTGCCTGTTGTGGCAGCGCTTGAGCAGCTTAATACTGAGGATTTGATTCGTATT
TTAACAGAGCCTAGAAATGCCCTTGTGAAGCAATATCAAGCCTTGCTGTCATATGATGGCGTAGAGCTTGAGTTTGAAAA
GGGAGCTCTGGAAGCTATTGCAGGCAGAGCTATTGAGCGCAAGACTGGTGCGCGTGGTCTGAGGTCTATTATCGAAGAAA
CCATGCTGGATATCATGTTTGAGGTGCCAAGCCAAGAGGAAGTAACCAAGGTACGCATTACTAAGGAAGCTGTCGAAGGT
CAATCAAAGCCTATTTTAGAGATAGCCTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpX | Streptococcus mutans UA159 |
88.753 |
100 |
0.888 |
| clpX | Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819 |
59.102 |
98.044 |
0.579 |