Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HCW_RS06515 Genome accession   NC_017737
Coordinates   1402076..1403869 (-) Length   597 a.a.
NCBI ID   WP_014661432.1    Uniprot ID   I0ENP5
Organism   Helicobacter cetorum MIT 00-7128     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1397076..1408869
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HCW_RS06490 - 1397772..1398595 (-) 824 Protein_1288 glycosyltransferase family 25 protein -
  HCW_RS06495 (HCW_06510) trxB 1399108..1400043 (-) 936 WP_014661428.1 thioredoxin-disulfide reductase -
  HCW_RS06500 (HCW_06515) trxA 1400049..1400369 (-) 321 WP_014661429.1 thioredoxin -
  HCW_RS06505 (HCW_06520) - 1400456..1400800 (-) 345 WP_014661430.1 YraN family protein -
  HCW_RS06510 (HCW_06525) - 1400797..1402065 (-) 1269 WP_014661431.1 homoserine dehydrogenase -
  HCW_RS06515 (HCW_06530) uvrC 1402076..1403869 (-) 1794 WP_014661432.1 excinuclease ABC subunit UvrC Machinery gene
  HCW_RS10025 - 1403872..1404072 (-) 201 Protein_1294 hypothetical protein -
  HCW_RS10030 - 1404132..1404333 (-) 202 Protein_1295 hypothetical protein -
  HCW_RS06525 (HCW_06540) - 1404325..1404504 (+) 180 WP_014661434.1 hypothetical protein -
  HCW_RS06530 (HCW_06545) - 1404523..1405158 (-) 636 WP_014661435.1 ATP-binding cassette domain-containing protein -
  HCW_RS06535 (HCW_06550) - 1405162..1406721 (-) 1560 WP_043902673.1 ABC transporter permease/substrate-binding protein -
  HCW_RS06540 (HCW_06555) - 1406805..1408235 (+) 1431 WP_043902675.1 4Fe-4S dicluster domain-containing protein -
  HCW_RS06545 (HCW_06560) - 1408241..1408846 (+) 606 WP_014661438.1 hypothetical protein -

Sequence

Protein


Download         Length: 597 a.a.        Molecular weight: 69309.50 Da        Isoelectric Point: 9.4911

>NTDB_id=50477 HCW_RS06515 WP_014661432.1 1402076..1403869(-) (uvrC) [Helicobacter cetorum MIT 00-7128]
MSSLLASLKNLPECSGVYQYFDKDNQLLYIGKAKNLKKRVRSYFSIQDDEVFVNKRNSPRIQIMAHQIRSLQTILVEHEQ
DALILENSLIKQLKPKYNILLRDDKTYPYIYMDFSVDFPIPLITRKVLKQSNIKVFGPFTSGAKDILDSLYELLPLVQKK
NCIKDKKACLFYQIERCKAPCENKITKEEYLKIAQRALEMIENKDLLVKELALKMERLSNHLRFEEALIYRDRITRIKKI
APNLRMDLAKLYDLDIFAFYSEGHNAVLVKMFMREGKIISSAFERLHSQNDFDIEEVIKQAILNHYQAHLPFVPEQILLA
QSCNDETLLELETFLNNRYHKKVSLVVPKRGDKFALIQIAMTNAKEIFNAKALEFLDEEELLLNIQELFSLRLLPYRVEV
FDTSHHANKHCVGGMIVYENKEFQKDSYRRYHLEGENEYAQMTELLTRRALSFDKNPPPDLWVIDGGKAQLKIALEVIAS
SGSSVEVIAISKEKRDFKAYRSKGGAKDMIHTSSQTLALLPSDKRLQWVQKLRDESHRYAISFHRAQKQASVKKIALLEE
KGIGKASVKKLLDYFGSFEAIEKASEQEKNAVLRKRI

Nucleotide


Download         Length: 1794 bp        

>NTDB_id=50477 HCW_RS06515 WP_014661432.1 1402076..1403869(-) (uvrC) [Helicobacter cetorum MIT 00-7128]
ATGTCTAGTTTGCTTGCTAGTTTAAAGAACTTGCCTGAATGTAGTGGGGTGTATCAATATTTTGACAAAGACAACCAACT
ACTTTATATTGGCAAGGCTAAGAATTTAAAAAAGCGTGTGAGAAGTTATTTTTCTATTCAAGATGATGAAGTGTTTGTAA
ATAAGCGTAATAGCCCTCGTATTCAAATTATGGCACATCAAATTAGAAGTTTGCAAACCATTTTAGTAGAGCATGAACAA
GACGCTTTAATTTTAGAAAATTCTTTGATTAAGCAACTTAAACCTAAATACAATATCCTTTTAAGAGATGATAAAACTTA
CCCTTATATTTATATGGATTTTTCAGTTGATTTTCCTATCCCTTTAATCACACGAAAAGTCCTAAAACAATCTAACATAA
AGGTTTTTGGCCCTTTTACTAGCGGAGCAAAGGATATTTTAGATAGCTTGTATGAATTGCTTCCTTTGGTTCAAAAGAAA
AATTGTATTAAAGACAAAAAAGCATGCTTATTTTATCAAATAGAGCGTTGCAAAGCCCCATGCGAAAATAAAATCACTAA
AGAGGAATATTTGAAAATCGCTCAAAGAGCCTTAGAGATGATTGAAAATAAAGATTTGTTGGTTAAAGAACTAGCATTAA
AAATGGAGCGTTTATCTAATCATTTGCGTTTTGAAGAGGCGCTTATTTATAGAGATAGAATTACTAGGATTAAAAAAATT
GCTCCCAATTTGCGCATGGATTTGGCTAAGCTTTATGATTTAGATATTTTTGCGTTTTATAGTGAAGGGCATAATGCGGT
ATTAGTGAAGATGTTTATGCGAGAGGGGAAAATCATTTCTTCAGCCTTTGAAAGATTGCACTCTCAAAATGATTTTGATA
TTGAAGAAGTTATCAAGCAAGCGATTTTAAATCATTATCAAGCTCATTTGCCCTTTGTGCCAGAGCAAATTCTTTTAGCC
CAAAGCTGTAATGATGAAACCTTATTAGAATTAGAGACTTTTTTAAATAATAGGTATCATAAAAAAGTTTCTTTAGTGGT
GCCTAAAAGGGGCGATAAATTTGCTTTAATTCAAATTGCTATGACAAACGCTAAAGAAATTTTTAATGCTAAGGCTTTGG
AATTTTTAGACGAAGAAGAGCTTTTGTTAAATATTCAAGAATTATTTTCATTACGCTTATTGCCTTATAGGGTGGAAGTT
TTTGATACAAGTCATCATGCTAATAAGCATTGTGTGGGGGGAATGATTGTGTATGAAAATAAGGAATTTCAAAAAGATTC
TTACAGACGCTATCATTTAGAGGGCGAGAATGAATACGCTCAAATGACTGAATTACTCACTAGAAGGGCTTTGAGTTTTG
ATAAAAATCCCCCACCAGATTTATGGGTAATAGATGGCGGTAAAGCGCAACTAAAGATTGCTTTAGAAGTGATTGCAAGC
AGTGGGAGTTCTGTAGAAGTGATAGCTATTTCTAAGGAAAAAAGAGATTTTAAGGCCTATCGCTCTAAAGGGGGGGCTAA
AGATATGATTCATACAAGCTCACAAACTCTAGCCTTATTACCAAGCGATAAGCGTTTGCAATGGGTGCAAAAATTGCGTG
ATGAAAGCCATAGATATGCCATAAGCTTTCATAGAGCCCAAAAACAAGCAAGCGTTAAAAAAATCGCTCTTTTAGAAGAA
AAAGGCATAGGAAAAGCAAGTGTGAAAAAATTACTAGATTATTTTGGAAGTTTTGAGGCGATTGAAAAAGCAAGCGAGCA
AGAAAAAAACGCTGTTTTAAGAAAACGAATATAA

Domains

Predicted by InterproScan.

UvrB/uvrC motif (UVR)

(207-239)

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(386-541)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0ENP5

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

75.377

100

0.754

Multiple sequence alignment