Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   IXH55_RS07355 Genome accession   NZ_CP064772
Coordinates   1521940..1523289 (+) Length   449 a.a.
NCBI ID   WP_000815646.1    Uniprot ID   Q9XB96
Organism   Staphylococcus aureus strain TCH32767     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 1521940..1561441 1521940..1523289 within 0


Gene organization within MGE regions


Location: 1521940..1561441
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  IXH55_RS07355 (IXH55_07290) ccrA 1521940..1523289 (+) 1350 WP_000815646.1 recombinase family protein Machinery gene
  IXH55_RS07360 (IXH55_07295) ccrB 1523311..1524939 (+) 1629 WP_001186602.1 recombinase family protein Machinery gene
  IXH55_RS07365 (IXH55_07300) - 1525457..1525807 (+) 351 WP_000859155.1 SAUGI family uracil-DNA glycosylase inhibitor -
  IXH55_RS07370 (IXH55_07305) - 1525894..1526205 (+) 312 WP_000700853.1 DUF960 family protein -
  IXH55_RS07375 (IXH55_07310) - 1526223..1526729 (+) 507 WP_001092169.1 DUF1643 domain-containing protein -
  IXH55_RS07380 (IXH55_07315) - 1526750..1527067 (+) 318 WP_000659050.1 JAB domain-containing protein -
  IXH55_RS07385 (IXH55_07320) - 1527186..1528271 (+) 1086 WP_000868132.1 tyrosine-type recombinase/integrase -
  IXH55_RS07390 (IXH55_07325) - 1528268..1530160 (+) 1893 WP_001557544.1 site-specific integrase -
  IXH55_RS07395 (IXH55_07330) - 1530167..1530544 (+) 378 WP_000361059.1 DUF6262 family protein -
  IXH55_RS07400 (IXH55_07335) - 1530695..1531477 (+) 783 WP_000067268.1 aminoglycoside nucleotidyltransferase ANT(9)-Ia -
  IXH55_RS07405 (IXH55_07340) erm(A) 1531603..1532334 (-) 732 WP_001072201.1 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) -
  IXH55_RS07410 (IXH55_07350) - 1532830..1533492 (+) 663 WP_001092058.1 class I SAM-dependent methyltransferase -
  IXH55_RS07420 (IXH55_07360) - 1533837..1534475 (-) 639 Protein_1462 sulfite exporter TauE/SafE family protein -
  IXH55_RS07425 (IXH55_07365) cstR 1534475..1534735 (-) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  IXH55_RS07430 (IXH55_07370) - 1534871..1535935 (+) 1065 WP_000438836.1 DsrE/DsrF/DrsH-like family protein -
  IXH55_RS07435 (IXH55_07375) cstB 1535968..1537302 (+) 1335 Protein_1465 persulfide dioxygenase-sulfurtransferase CstB -
  IXH55_RS07440 (IXH55_07380) - 1537416..1538525 (-) 1110 WP_000943131.1 ROK family transcriptional regulator -
  IXH55_RS07445 (IXH55_07385) psm-mec 1538880..1538948 (+) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  IXH55_RS07450 (IXH55_07390) mecI 1539033..1539404 (-) 372 WP_000369214.1 mecA-type methicillin resistance repressor MecI -
  IXH55_RS07455 (IXH55_07395) mecR1 1539404..1541161 (-) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  IXH55_RS07460 (IXH55_07400) mecA 1541258..1543267 (+) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  IXH55_RS07465 (IXH55_07405) - 1543313..1543741 (-) 429 WP_000872606.1 MaoC family dehydratase -
  IXH55_RS07470 (IXH55_07410) - 1543838..1544581 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  IXH55_RS07475 (IXH55_07415) - 1544846..1545520 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  IXH55_RS07480 (IXH55_07420) aadD1 1545713..1546483 (+) 771 WP_001795128.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  IXH55_RS07485 (IXH55_07425) bleO 1546700..1547104 (+) 405 WP_001242578.1 bleomycin binding protein -
  IXH55_RS07490 (IXH55_07430) mobV 1547611..1548873 (+) 1263 WP_000119405.1 MobV family relaxase -
  IXH55_RS07495 (IXH55_07435) - 1549118..1550101 (+) 984 Protein_1477 protein rep -
  IXH55_RS07500 (IXH55_07445) - 1550192..1550866 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  IXH55_RS07505 (IXH55_07450) - 1550898..1551137 (-) 240 WP_001282728.1 hypothetical protein -
  IXH55_RS07510 (IXH55_07455) - 1551552..1552808 (-) 1257 WP_000566670.1 DUF3578 domain-containing protein -
  IXH55_RS07515 (IXH55_07460) - 1554034..1555959 (-) 1926 WP_031783917.1 heavy metal translocating P-type ATPase -
  IXH55_RS07520 (IXH55_07465) - 1556289..1556615 (-) 327 WP_000391495.1 metalloregulator ArsR/SmtB family transcription factor -
  IXH55_RS07525 (IXH55_07470) - 1556822..1557181 (+) 360 WP_001631039.1 hypothetical protein -
  IXH55_RS07530 (IXH55_07475) - 1557293..1557631 (-) 339 Protein_1484 recombinase family protein -
  IXH55_RS07535 (IXH55_07480) - 1557640..1558269 (+) 630 Protein_1485 hypothetical protein -
  IXH55_RS07540 (IXH55_07485) - 1558456..1559816 (+) 1361 Protein_1486 recombinase family protein -
  IXH55_RS07545 (IXH55_07490) ccrB 1559813..1561441 (+) 1629 WP_001631035.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52607.20 Da        Isoelectric Point: 9.9585

>NTDB_id=504640 IXH55_RS07355 WP_000815646.1 1521940..1523289(+) (ccrA) [Staphylococcus aureus strain TCH32767]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=504640 IXH55_RS07355 WP_000815646.1 1521940..1523289(+) (ccrA) [Staphylococcus aureus strain TCH32767]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9XB96

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

100

100

1
  ccrA Staphylococcus aureus COL

74.833

100

0.748