Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrC   Type   Machinery gene
Locus tag   HCD_RS05785 Genome accession   NC_017735
Coordinates   1220641..1222434 (-) Length   597 a.a.
NCBI ID   WP_014659643.1    Uniprot ID   I0ET86
Organism   Helicobacter cetorum MIT 99-5656     
Function   integration of short DNA fragment (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1215641..1227434
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  HCD_RS05760 (HCD_05740) - 1216630..1217454 (-) 825 WP_014659638.1 glycosyltransferase family 25 protein -
  HCD_RS05765 (HCD_05745) trxB 1217675..1218610 (-) 936 WP_014659639.1 thioredoxin-disulfide reductase -
  HCD_RS05770 (HCD_05750) trxA 1218616..1218936 (-) 321 WP_014659640.1 thioredoxin -
  HCD_RS05775 (HCD_05755) - 1219027..1219371 (-) 345 WP_014659641.1 YraN family protein -
  HCD_RS05780 (HCD_05760) - 1219372..1220637 (-) 1266 WP_014659642.1 homoserine dehydrogenase -
  HCD_RS05785 (HCD_05765) uvrC 1220641..1222434 (-) 1794 WP_014659643.1 excinuclease ABC subunit UvrC Machinery gene
  HCD_RS05790 (HCD_05770) - 1222435..1222902 (-) 468 WP_014659644.1 hypothetical protein -
  HCD_RS09565 - 1222894..1223073 (+) 180 WP_041594831.1 hypothetical protein -
  HCD_RS05800 (HCD_05775) - 1223070..1223702 (-) 633 WP_014659645.1 ATP-binding cassette domain-containing protein -
  HCD_RS05805 (HCD_05780) - 1223706..1225304 (-) 1599 WP_050854963.1 ABC transporter permease/substrate-binding protein -

Sequence

Protein


Download         Length: 597 a.a.        Molecular weight: 68971.82 Da        Isoelectric Point: 10.0451

>NTDB_id=50456 HCD_RS05785 WP_014659643.1 1220641..1222434(-) (uvrC) [Helicobacter cetorum MIT 99-5656]
MASLLLSLKNLSSSSGVYQYFDKNHQLLYIGKAKNLKKRVRSYFSIRNGEVMPNIRTSLRIQMMVAQIAFLETILVEHEQ
DALILENSLIKQLKPKYNVLLRDDKTYPYIYMDFSSDFPIPLITRKVLKQPNIKVFGPFTSGAKDILDSLYELLPLVQKK
NCIKAKKACMFYQIERCKAPCENKITKEEYLKIAQRALEMIENKDLLIRELALKMERFSQNLRFEEALVYRDRMAKIQKI
APFTRMDLAKLYDLDIFAFYSENHKAVLVKMFMRKGKIISSAFEKIHSVNGFDTEEVIKQALINHYKAHLPLLPEQILLS
ACSNEVLIELQVFLNARYSKKITLSIPKKGDKLALVEIAMKNAKEIFNQEKTHNEEQILEEVRSLLNLECMPYRVEIFDT
SHHASSQCVGGMVVYENGVFQKKAYRCYHLEGVNEYAQMTELLTRRALKFAKEPPPNLWVVDGGKAQLKIALEVLKSSGS
FVEVVAISKEKRDFKAYRSKGGARDIIHTSSRTLTLLPSDKRLQWVQKLRDESHRYAISFHRSTKLKSVKQIALLEEKGI
GKASVKKLLDYFGSFEAIEKASEQEKNAVLRKRILRN

Nucleotide


Download         Length: 1794 bp        

>NTDB_id=50456 HCD_RS05785 WP_014659643.1 1220641..1222434(-) (uvrC) [Helicobacter cetorum MIT 99-5656]
ATGGCTAGTTTATTGCTGAGTTTGAAAAATCTTTCTAGTAGTAGTGGGGTGTATCAATATTTTGATAAAAACCATCAGTT
GCTCTATATCGGTAAGGCTAAGAATTTAAAAAAGCGCGTGAGAAGCTACTTTTCTATTCGTAATGGTGAAGTTATGCCAA
ATATCCGCACCAGCTTACGCATTCAAATGATGGTTGCTCAAATCGCTTTTTTAGAAACTATTCTTGTAGAGCATGAACAA
GACGCTTTGATTTTAGAAAATTCGCTGATTAAACAACTCAAACCTAAATACAATGTGCTACTAAGAGATGATAAAACTTA
CCCTTATATTTACATGGATTTTTCATCTGATTTTCCCATTCCTTTAATCACACGAAAAGTGCTAAAACAACCTAATATAA
AGGTTTTTGGCCCTTTTACTAGTGGAGCAAAAGATATTTTAGATAGTTTGTATGAATTGCTTCCTTTAGTCCAAAAGAAA
AATTGCATCAAGGCTAAAAAGGCATGCATGTTTTATCAAATAGAACGCTGCAAAGCCCCATGTGAAAATAAAATCACCAA
AGAAGAGTATTTAAAAATCGCTCAAAGAGCCTTAGAGATGATTGAAAATAAAGATTTGCTCATTAGAGAGCTTGCGTTAA
AAATGGAGCGGTTTTCTCAAAATTTGCGTTTTGAAGAAGCCCTTGTGTATAGAGATAGGATGGCTAAAATCCAAAAAATC
GCCCCTTTTACACGCATGGATTTAGCCAAGCTCTATGATTTGGATATTTTTGCTTTTTATAGTGAAAATCATAAAGCGGT
GTTAGTGAAAATGTTTATGCGTAAGGGTAAAATCATTTCTTCAGCGTTTGAAAAAATCCACTCTGTTAATGGTTTTGATA
CAGAAGAAGTTATCAAACAAGCCCTAATCAACCACTATAAAGCTCATTTGCCTTTGCTACCAGAACAAATTCTATTGAGT
GCTTGCTCTAATGAAGTGCTTATAGAGTTGCAAGTTTTTTTAAACGCCAGATACTCCAAAAAAATCACCCTTAGTATTCC
TAAAAAGGGCGATAAACTTGCTTTAGTAGAAATCGCTATGAAAAATGCCAAAGAGATTTTTAACCAAGAAAAGACCCATA
ATGAAGAGCAAATCCTTGAAGAAGTGCGTTCGCTTTTAAACTTAGAATGCATGCCTTATAGGGTAGAAATCTTTGACACA
AGCCACCATGCAAGCAGTCAATGCGTAGGGGGAATGGTCGTGTATGAAAATGGTGTTTTTCAAAAAAAGGCTTATAGGTG
TTATCATTTAGAAGGGGTGAATGAATACGCTCAAATGACGGAGTTACTCACTAGAAGAGCCTTGAAATTTGCTAAGGAGC
CACCGCCTAATTTGTGGGTAGTAGATGGGGGTAAAGCCCAGTTAAAAATCGCTTTAGAAGTTCTAAAAAGTAGCGGGAGT
TTTGTAGAAGTGGTTGCCATTTCTAAGGAAAAGAGAGATTTTAAAGCGTATCGCTCTAAAGGGGGGGCTAGAGATATTAT
TCATACCAGTTCACGAACTCTGACTCTATTACCGAGCGATAAACGCTTGCAATGGGTGCAAAAATTGCGTGATGAAAGCC
ATAGGTATGCGATAAGCTTTCATCGTTCTACCAAACTTAAAAGCGTTAAACAAATCGCTCTTTTAGAAGAAAAGGGCATA
GGAAAAGCAAGTGTGAAAAAATTATTAGATTATTTTGGAAGTTTTGAAGCGATAGAAAAAGCGAGCGAGCAAGAAAAAAA
CGCTGTTTTAAGAAAACGAATACTAAGGAATTAA

Domains

Predicted by InterproScan.

GIY-YIG catalytic domain (GIY-YIG)

(15-98)

UvrC RNAse H endonuclease domain (UvrC_RNaseH_dom)

(384-538)

UvrB/uvrC motif (UVR)

(207-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I0ET86

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrC Helicobacter pylori 26695

84.343

99.497

0.839

Multiple sequence alignment