Detailed information NTG0504017

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: HWI30_RS04580
• Genome accession: NZ_CP064650
• Coordinates: 974609..975655 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain UMCG357
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 969609..980655

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
HWI30_RS04555 (HWI30_04520)	isaB	970750..971286 (+)	537	WP_002470337.1	immunodominant staphylococcal antigen IsaB family protein	-
HWI30_RS04560 (HWI30_04525)	-	971437..972423 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
HWI30_RS04565 (HWI30_04530)	map	972597..973352 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
HWI30_RS04570 (HWI30_04535)	-	973510..973896 (+)	387	WP_001830382.1	hypothetical protein	-
HWI30_RS04575 (HWI30_04540)	liaF	973911..974612 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
HWI30_RS04580 (HWI30_04545)	vraS	974609..975655 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
HWI30_RS04585 (HWI30_04550)	vraR	975645..976274 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
HWI30_RS04590 (HWI30_04555)	-	976331..977509 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
HWI30_RS04595 (HWI30_04560)	-	977916..978200 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
HWI30_RS04600 (HWI30_04565)	-	978208..978672 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
HWI30_RS04605 (HWI30_04570)	-	978813..979028 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
HWI30_RS04610 (HWI30_04575)	-	979030..980271 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=504017 HWI30_RS04580 WP_001830374.1 974609..975655(+) (vraS) [Staphylococcus epidermidis strain UMCG357]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=504017 HWI30_RS04580 WP_001830374.1 974609..975655(+) (vraS) [Staphylococcus epidermidis strain UMCG357]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92