Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI16_RS03425 | Genome accession | NZ_CP064624 |
| Coordinates | 696277..696852 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG343 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 697253..742488 | 696277..696852 | flank | 401 |
Gene organization within MGE regions
Location: 696277..742488
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI16_RS03425 (HWI16_03375) | comK/comK1 | 696277..696852 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI16_RS03440 (HWI16_03390) | - | 697253..698302 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI16_RS03445 (HWI16_03395) | - | 698413..698610 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI16_RS03450 (HWI16_03400) | - | 698607..699014 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI16_RS03455 (HWI16_03405) | - | 699008..699445 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI16_RS03460 (HWI16_03410) | - | 699557..700225 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI16_RS03465 (HWI16_03415) | - | 700243..700701 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI16_RS03470 (HWI16_03420) | - | 700723..701037 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI16_RS03475 (HWI16_03425) | - | 701190..701402 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI16_RS03480 (HWI16_03430) | - | 701446..701586 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI16_RS03485 (HWI16_03435) | - | 701579..701803 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI16_RS03490 (HWI16_03440) | - | 701853..702593 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI16_RS03495 (HWI16_03445) | - | 702606..702815 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI16_RS03500 (HWI16_03450) | - | 702829..702975 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI16_RS03505 (HWI16_03455) | - | 702962..703240 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI16_RS03510 (HWI16_03460) | - | 703335..703511 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI16_RS03515 (HWI16_03465) | - | 703573..703824 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI16_RS03520 (HWI16_03470) | - | 703817..704302 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI16_RS03525 (HWI16_03475) | - | 704303..704929 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI16_RS03530 (HWI16_03480) | - | 704922..705338 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI16_RS03535 (HWI16_03485) | - | 705352..706041 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI16_RS03540 (HWI16_03490) | - | 706019..706249 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI16_RS03545 (HWI16_03495) | - | 706255..706470 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI16_RS03550 (HWI16_03500) | - | 706457..707185 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI16_RS03555 (HWI16_03505) | - | 707191..707544 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI16_RS03560 (HWI16_03510) | - | 707534..708781 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI16_RS03565 (HWI16_03515) | - | 708778..709008 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI16_RS03570 (HWI16_03520) | - | 708977..709201 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI16_RS03575 (HWI16_03525) | - | 709212..709628 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI16_RS03580 (HWI16_03530) | - | 709615..709989 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI16_RS03585 (HWI16_03535) | - | 709989..710180 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI16_RS03590 (HWI16_03540) | - | 710181..710540 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI16_RS03595 (HWI16_03545) | - | 710537..710989 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI16_RS03600 (HWI16_03550) | - | 710979..711266 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI16_RS03605 (HWI16_03555) | - | 711282..711962 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI16_RS03610 (HWI16_03560) | - | 711959..712159 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI16_RS03615 (HWI16_03565) | - | 712143..712496 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI16_RS03620 (HWI16_03570) | - | 712477..712674 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI16_RS03625 (HWI16_03575) | - | 712675..713202 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI16_RS03630 (HWI16_03580) | - | 713364..713522 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI16_RS03635 (HWI16_03585) | - | 713581..713859 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI16_RS03640 (HWI16_03590) | rinB | 713852..714019 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI16_RS03645 (HWI16_03595) | - | 714019..714168 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI16_RS03650 (HWI16_03600) | - | 714185..714631 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI16_RS03655 (HWI16_03605) | - | 715226..715576 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI16_RS03660 (HWI16_03610) | - | 715719..716189 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI16_RS03665 (HWI16_03615) | - | 716182..717933 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI16_RS03670 (HWI16_03620) | - | 717945..718139 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI16_RS03675 (HWI16_03625) | - | 718142..719374 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI16_RS03680 (HWI16_03630) | - | 719364..719921 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI16_RS03685 (HWI16_03635) | - | 719961..721310 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI16_RS03690 (HWI16_03640) | - | 721329..721670 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI16_RS03695 (HWI16_03645) | - | 721660..721989 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI16_RS03700 (HWI16_03650) | - | 722103..722390 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI16_RS03705 (HWI16_03655) | - | 722393..722797 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI16_RS03710 (HWI16_03660) | - | 722810..723439 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI16_RS03715 (HWI16_03665) | - | 723458..723643 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI16_RS03720 (HWI16_03670) | gpG | 723707..724069 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI16_RS03725 (HWI16_03675) | gpGT | 724102..724254 (+) | 153 | WP_153801570.1 | phage tail assembly chaperone GT | - |
| HWI16_RS03730 (HWI16_03680) | - | 724283..728839 (+) | 4557 | Protein_721 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI16_RS03735 (HWI16_03685) | - | 728841..729674 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI16_RS03740 (HWI16_03690) | - | 729684..731243 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI16_RS03745 (HWI16_03695) | - | 731236..731409 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI16_RS03750 (HWI16_03700) | - | 731425..733287 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI16_RS03755 (HWI16_03705) | - | 733287..734501 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI16_RS03760 (HWI16_03710) | - | 734506..735129 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI16_RS03765 (HWI16_03715) | - | 735126..735551 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI16_RS03770 (HWI16_03720) | - | 735538..735945 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI16_RS03775 (HWI16_03725) | - | 736071..736337 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI16_RS03780 (HWI16_03730) | - | 736337..737719 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI16_RS03785 (HWI16_03735) | - | 737797..738723 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI16_RS03790 (HWI16_03740) | - | 738916..739443 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI16_RS03795 (HWI16_03745) | - | 739433..739831 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
| HWI16_RS03800 | mobV | 740957..741496 (+) | 540 | Protein_735 | MobV family relaxase | - |
| HWI16_RS03805 (HWI16_03760) | - | 741698..741934 (+) | 237 | WP_001829451.1 | hypothetical protein | - |
| HWI16_RS03810 (HWI16_03765) | - | 742147..742488 (+) | 342 | WP_002456621.1 | fatty acid desaturase | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503715 HWI16_RS03425 WP_001829272.1 696277..696852(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG343]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503715 HWI16_RS03425 WP_001829272.1 696277..696852(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG343]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |