Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI20_RS03420 | Genome accession | NZ_CP064613 |
| Coordinates | 696328..696903 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG347 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 697304..742527 | 696328..696903 | flank | 401 |
Gene organization within MGE regions
Location: 696328..742527
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI20_RS03420 (HWI20_03385) | comK/comK1 | 696328..696903 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI20_RS03435 (HWI20_03400) | - | 697304..698353 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI20_RS03440 (HWI20_03405) | - | 698464..698661 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI20_RS03445 (HWI20_03410) | - | 698658..699065 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI20_RS03450 (HWI20_03415) | - | 699059..699496 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI20_RS03455 (HWI20_03420) | - | 699608..700276 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI20_RS03460 (HWI20_03425) | - | 700294..700752 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI20_RS03465 (HWI20_03430) | - | 700774..701088 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI20_RS03470 (HWI20_03435) | - | 701241..701453 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI20_RS03475 (HWI20_03440) | - | 701497..701637 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI20_RS03480 (HWI20_03445) | - | 701630..701854 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI20_RS03485 (HWI20_03450) | - | 701904..702644 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI20_RS03490 (HWI20_03455) | - | 702657..702866 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI20_RS03495 (HWI20_03460) | - | 702880..703026 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI20_RS03500 (HWI20_03465) | - | 703013..703291 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI20_RS03505 (HWI20_03470) | - | 703386..703562 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI20_RS03510 (HWI20_03475) | - | 703624..703875 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI20_RS03515 (HWI20_03480) | - | 703868..704353 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI20_RS03520 (HWI20_03485) | - | 704354..704980 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI20_RS03525 (HWI20_03490) | - | 704973..705389 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI20_RS03530 (HWI20_03495) | - | 705403..706092 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI20_RS03535 (HWI20_03500) | - | 706070..706300 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI20_RS03540 (HWI20_03505) | - | 706306..706521 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI20_RS03545 (HWI20_03510) | - | 706508..707236 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI20_RS03550 (HWI20_03515) | - | 707242..707595 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI20_RS03555 (HWI20_03520) | - | 707585..708832 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI20_RS03560 (HWI20_03525) | - | 708829..709059 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI20_RS03565 (HWI20_03530) | - | 709028..709240 (+) | 213 | WP_408022879.1 | DUF3269 family protein | - |
| HWI20_RS03570 (HWI20_03535) | - | 709251..709667 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI20_RS03575 (HWI20_03540) | - | 709654..710028 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI20_RS03580 (HWI20_03545) | - | 710028..710219 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI20_RS03585 (HWI20_03550) | - | 710220..710579 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI20_RS03590 (HWI20_03555) | - | 710576..711028 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI20_RS03595 (HWI20_03560) | - | 711018..711305 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI20_RS03600 (HWI20_03565) | - | 711321..712001 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI20_RS03605 (HWI20_03570) | - | 711998..712198 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI20_RS03610 (HWI20_03575) | - | 712182..712535 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI20_RS03615 (HWI20_03580) | - | 712516..712713 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI20_RS03620 (HWI20_03585) | - | 712714..713241 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI20_RS03625 (HWI20_03590) | - | 713403..713561 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI20_RS03630 (HWI20_03595) | - | 713620..713898 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI20_RS03635 (HWI20_03600) | rinB | 713891..714058 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI20_RS03640 (HWI20_03605) | - | 714058..714207 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI20_RS03645 (HWI20_03610) | - | 714224..714670 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI20_RS03650 (HWI20_03615) | - | 715265..715615 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI20_RS03655 (HWI20_03620) | - | 715758..716228 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI20_RS03660 (HWI20_03625) | - | 716221..717972 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI20_RS03665 (HWI20_03630) | - | 717984..718178 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI20_RS03670 (HWI20_03635) | - | 718181..719413 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI20_RS03675 (HWI20_03640) | - | 719403..719960 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI20_RS03680 (HWI20_03645) | - | 720000..721349 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI20_RS03685 (HWI20_03650) | - | 721368..721709 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI20_RS03690 (HWI20_03655) | - | 721699..722028 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI20_RS03695 (HWI20_03660) | - | 722142..722429 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI20_RS03700 (HWI20_03665) | - | 722432..722836 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI20_RS03705 (HWI20_03670) | - | 722849..723478 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI20_RS03710 (HWI20_03675) | - | 723497..723682 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI20_RS03715 (HWI20_03680) | gpG | 723746..724108 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI20_RS03720 (HWI20_03685) | gpGT | 724153..724293 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI20_RS03725 (HWI20_03690) | - | 724322..728878 (+) | 4557 | Protein_720 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI20_RS03730 (HWI20_03695) | - | 728880..729713 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI20_RS03735 (HWI20_03700) | - | 729723..731282 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI20_RS03740 (HWI20_03705) | - | 731275..731448 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI20_RS03745 (HWI20_03710) | - | 731464..733326 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI20_RS03750 (HWI20_03715) | - | 733326..734540 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI20_RS03755 (HWI20_03720) | - | 734545..735168 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI20_RS03760 (HWI20_03725) | - | 735165..735590 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI20_RS03765 (HWI20_03730) | - | 735577..735984 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI20_RS03770 (HWI20_03735) | - | 736110..736376 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI20_RS03775 (HWI20_03740) | - | 736376..737758 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI20_RS03780 (HWI20_03745) | - | 737836..738762 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI20_RS03785 (HWI20_03750) | - | 738955..739482 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI20_RS03790 (HWI20_03755) | - | 739472..739870 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
| HWI20_RS03795 | mobV | 740996..741535 (+) | 540 | Protein_734 | MobV family relaxase | - |
| HWI20_RS03800 (HWI20_03770) | - | 741737..741973 (+) | 237 | WP_001829451.1 | hypothetical protein | - |
| HWI20_RS03805 (HWI20_03775) | - | 742186..742527 (+) | 342 | WP_002456621.1 | fatty acid desaturase | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503562 HWI20_RS03420 WP_001829272.1 696328..696903(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG347]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503562 HWI20_RS03420 WP_001829272.1 696328..696903(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG347]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |