Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI22_RS03420 | Genome accession | NZ_CP064606 |
| Coordinates | 695041..695616 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG349 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 696017..738595 | 695041..695616 | flank | 401 |
Gene organization within MGE regions
Location: 695041..738595
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI22_RS03420 (HWI22_03380) | comK/comK1 | 695041..695616 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI22_RS03435 (HWI22_03395) | - | 696017..697066 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI22_RS03440 (HWI22_03400) | - | 697177..697374 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI22_RS03445 (HWI22_03405) | - | 697371..697778 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI22_RS03450 (HWI22_03410) | - | 697772..698209 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI22_RS03455 (HWI22_03415) | - | 698321..698989 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI22_RS03460 (HWI22_03420) | - | 699007..699465 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI22_RS03465 (HWI22_03425) | - | 699487..699801 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI22_RS03470 (HWI22_03430) | - | 699954..700166 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI22_RS03475 (HWI22_03435) | - | 700210..700350 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI22_RS03480 (HWI22_03440) | - | 700343..700567 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI22_RS03485 (HWI22_03445) | - | 700617..701357 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI22_RS03490 (HWI22_03450) | - | 701370..701579 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI22_RS03495 (HWI22_03455) | - | 701593..701739 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI22_RS03500 (HWI22_03460) | - | 701726..702004 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI22_RS03505 (HWI22_03465) | - | 702099..702275 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI22_RS03510 (HWI22_03470) | - | 702337..702588 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI22_RS03515 (HWI22_03475) | - | 702581..703066 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI22_RS03520 (HWI22_03480) | - | 703067..703693 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI22_RS03525 (HWI22_03485) | - | 703686..704102 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI22_RS03530 (HWI22_03490) | - | 704116..704805 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI22_RS03535 (HWI22_03495) | - | 704783..705013 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI22_RS03540 (HWI22_03500) | - | 705019..705234 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI22_RS03545 (HWI22_03505) | - | 705221..705949 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI22_RS03550 (HWI22_03510) | - | 705955..706308 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI22_RS03555 (HWI22_03515) | - | 706298..707545 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI22_RS03560 (HWI22_03520) | - | 707542..707772 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI22_RS03565 (HWI22_03525) | - | 707741..707965 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI22_RS03570 (HWI22_03530) | - | 707976..708392 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI22_RS03575 (HWI22_03535) | - | 708379..708753 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI22_RS03580 (HWI22_03540) | - | 708753..708944 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI22_RS03585 (HWI22_03545) | - | 708945..709304 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI22_RS03590 (HWI22_03550) | - | 709301..709753 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI22_RS03595 (HWI22_03555) | - | 709743..710030 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI22_RS03600 (HWI22_03560) | - | 710046..710726 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI22_RS03605 (HWI22_03565) | - | 710723..710923 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI22_RS03610 (HWI22_03570) | - | 710907..711260 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI22_RS03615 (HWI22_03575) | - | 711241..711438 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI22_RS03620 (HWI22_03580) | - | 711439..711966 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI22_RS03625 (HWI22_03585) | - | 712128..712286 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI22_RS03630 (HWI22_03590) | - | 712345..712623 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI22_RS03635 (HWI22_03595) | rinB | 712616..712783 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI22_RS03640 (HWI22_03600) | - | 712783..712932 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI22_RS03645 (HWI22_03605) | - | 712949..713395 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI22_RS03650 (HWI22_03610) | - | 713990..714340 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI22_RS03655 (HWI22_03615) | - | 714483..714953 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI22_RS03660 (HWI22_03620) | - | 714946..716697 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI22_RS03665 (HWI22_03625) | - | 716709..716903 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI22_RS03670 (HWI22_03630) | - | 716906..718138 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI22_RS03675 (HWI22_03635) | - | 718128..718685 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI22_RS03680 (HWI22_03640) | - | 718725..720074 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI22_RS03685 (HWI22_03645) | - | 720093..720434 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI22_RS03690 (HWI22_03650) | - | 720424..720753 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI22_RS03695 (HWI22_03655) | - | 720867..721154 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI22_RS03700 (HWI22_03660) | - | 721157..721561 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI22_RS03705 (HWI22_03665) | - | 721574..722203 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI22_RS03710 (HWI22_03670) | - | 722222..722407 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI22_RS03715 (HWI22_03675) | gpG | 722471..722833 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI22_RS03720 | gpGT | 722878..723018 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI22_RS03725 (HWI22_03680) | - | 723047..727603 (+) | 4557 | Protein_720 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI22_RS03730 (HWI22_03685) | - | 727605..728438 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI22_RS03735 (HWI22_03690) | - | 728448..730007 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI22_RS03740 (HWI22_03695) | - | 730000..730173 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI22_RS03745 (HWI22_03700) | - | 730189..732051 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI22_RS03750 (HWI22_03705) | - | 732051..733265 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI22_RS03755 (HWI22_03710) | - | 733270..733893 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI22_RS03760 (HWI22_03715) | - | 733890..734315 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI22_RS03765 (HWI22_03720) | - | 734302..734709 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI22_RS03770 (HWI22_03725) | - | 734835..735101 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI22_RS03775 (HWI22_03730) | - | 735101..736483 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI22_RS03780 (HWI22_03735) | - | 736561..737487 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI22_RS03785 (HWI22_03740) | - | 737680..738207 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI22_RS03790 (HWI22_03745) | - | 738197..738595 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503486 HWI22_RS03420 WP_001829272.1 695041..695616(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG349]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503486 HWI22_RS03420 WP_001829272.1 695041..695616(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG349]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |