Detailed information
Bioinformatically predicted
Overview
| Name | comK/comK1 | Type | Regulator |
| Locus tag | HWI26_RS03420 | Genome accession | NZ_CP064590 |
| Coordinates | 696373..696948 (+) | Length | 191 a.a. |
| NCBI ID | WP_001829272.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain UMCG353 | ||
| Function | promote expression of competence genes (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 697349..743916 | 696373..696948 | flank | 401 |
Gene organization within MGE regions
Location: 696373..743916
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| HWI26_RS03420 (HWI26_03380) | comK/comK1 | 696373..696948 (+) | 576 | WP_001829272.1 | competence protein ComK | Regulator |
| HWI26_RS03435 (HWI26_03395) | - | 697349..698398 (-) | 1050 | WP_002504795.1 | site-specific integrase | - |
| HWI26_RS03440 (HWI26_03400) | - | 698509..698706 (+) | 198 | WP_002497576.1 | hypothetical protein | - |
| HWI26_RS03445 (HWI26_03405) | - | 698703..699110 (-) | 408 | WP_002497577.1 | TIR domain-containing protein | - |
| HWI26_RS03450 (HWI26_03410) | - | 699104..699541 (-) | 438 | WP_002497578.1 | DUF4231 domain-containing protein | - |
| HWI26_RS03455 (HWI26_03415) | - | 699653..700321 (-) | 669 | WP_002504794.1 | hypothetical protein | - |
| HWI26_RS03460 (HWI26_03420) | - | 700339..700797 (-) | 459 | WP_002504200.1 | ImmA/IrrE family metallo-endopeptidase | - |
| HWI26_RS03465 (HWI26_03425) | - | 700819..701133 (-) | 315 | WP_002504199.1 | helix-turn-helix transcriptional regulator | - |
| HWI26_RS03470 (HWI26_03430) | - | 701286..701498 (+) | 213 | WP_002456362.1 | helix-turn-helix transcriptional regulator | - |
| HWI26_RS03475 (HWI26_03435) | - | 701542..701682 (+) | 141 | WP_002485815.1 | hypothetical protein | - |
| HWI26_RS03480 (HWI26_03440) | - | 701675..701899 (-) | 225 | WP_002504198.1 | hypothetical protein | - |
| HWI26_RS03485 (HWI26_03445) | - | 701949..702689 (+) | 741 | WP_002504197.1 | phage repressor protein | - |
| HWI26_RS03490 (HWI26_03450) | - | 702702..702911 (+) | 210 | WP_001830281.1 | hypothetical protein | - |
| HWI26_RS03495 (HWI26_03455) | - | 702925..703071 (+) | 147 | WP_002504793.1 | hypothetical protein | - |
| HWI26_RS03500 (HWI26_03460) | - | 703058..703336 (-) | 279 | WP_002484728.1 | hypothetical protein | - |
| HWI26_RS03505 (HWI26_03465) | - | 703431..703607 (+) | 177 | WP_002484719.1 | hypothetical protein | - |
| HWI26_RS03510 (HWI26_03470) | - | 703669..703920 (+) | 252 | WP_002484751.1 | hypothetical protein | - |
| HWI26_RS03515 (HWI26_03475) | - | 703913..704398 (+) | 486 | WP_002484734.1 | siphovirus Gp157 family protein | - |
| HWI26_RS03520 (HWI26_03480) | - | 704399..705025 (+) | 627 | WP_002469464.1 | DUF1071 domain-containing protein | - |
| HWI26_RS03525 (HWI26_03485) | - | 705018..705434 (+) | 417 | WP_002484754.1 | single-stranded DNA-binding protein | - |
| HWI26_RS03530 (HWI26_03490) | - | 705448..706137 (+) | 690 | WP_002504792.1 | putative HNHc nuclease | - |
| HWI26_RS03535 (HWI26_03495) | - | 706115..706345 (+) | 231 | WP_002504791.1 | helix-turn-helix domain-containing protein | - |
| HWI26_RS03540 (HWI26_03500) | - | 706351..706566 (+) | 216 | WP_002504790.1 | helix-turn-helix domain-containing protein | - |
| HWI26_RS03545 (HWI26_03505) | - | 706553..707281 (+) | 729 | WP_002504789.1 | DnaD domain protein | - |
| HWI26_RS03550 (HWI26_03510) | - | 707287..707640 (+) | 354 | WP_002504788.1 | hypothetical protein | - |
| HWI26_RS03555 (HWI26_03515) | - | 707630..708877 (+) | 1248 | WP_002504787.1 | DnaB-like helicase C-terminal domain-containing protein | - |
| HWI26_RS03560 (HWI26_03520) | - | 708874..709104 (+) | 231 | WP_002504786.1 | hypothetical protein | - |
| HWI26_RS03565 (HWI26_03525) | - | 709073..709297 (+) | 225 | WP_002456377.1 | DUF3269 family protein | - |
| HWI26_RS03570 (HWI26_03530) | - | 709308..709724 (+) | 417 | WP_002504785.1 | DUF1064 domain-containing protein | - |
| HWI26_RS03575 (HWI26_03535) | - | 709711..710085 (+) | 375 | WP_002484718.1 | hypothetical protein | - |
| HWI26_RS03580 (HWI26_03540) | - | 710085..710276 (+) | 192 | WP_002484773.1 | hypothetical protein | - |
| HWI26_RS03585 (HWI26_03545) | - | 710277..710636 (+) | 360 | WP_002484760.1 | SA1788 family PVL leukocidin-associated protein | - |
| HWI26_RS03590 (HWI26_03550) | - | 710633..711085 (+) | 453 | WP_002484724.1 | DUF3310 domain-containing protein | - |
| HWI26_RS03595 (HWI26_03555) | - | 711075..711362 (+) | 288 | WP_002484753.1 | hypothetical protein | - |
| HWI26_RS03600 (HWI26_03560) | - | 711378..712058 (+) | 681 | WP_002504784.1 | hypothetical protein | - |
| HWI26_RS03605 (HWI26_03565) | - | 712055..712255 (+) | 201 | WP_002504783.1 | hypothetical protein | - |
| HWI26_RS03610 (HWI26_03570) | - | 712239..712592 (+) | 354 | WP_002504782.1 | hypothetical protein | - |
| HWI26_RS03615 (HWI26_03575) | - | 712573..712770 (+) | 198 | WP_002504781.1 | Lar family restriction alleviation protein | - |
| HWI26_RS03620 (HWI26_03580) | - | 712771..713298 (+) | 528 | WP_002504780.1 | dUTPase | - |
| HWI26_RS03625 (HWI26_03585) | - | 713460..713618 (+) | 159 | WP_002504779.1 | DUF1381 domain-containing protein | - |
| HWI26_RS03630 (HWI26_03590) | - | 713677..713955 (+) | 279 | WP_002504778.1 | hypothetical protein | - |
| HWI26_RS03635 (HWI26_03595) | rinB | 713948..714115 (+) | 168 | WP_002504777.1 | transcriptional activator RinB | - |
| HWI26_RS03640 (HWI26_03600) | - | 714115..714264 (+) | 150 | WP_002484731.1 | DUF1514 family protein | - |
| HWI26_RS03645 (HWI26_03605) | - | 714281..714727 (+) | 447 | WP_002484732.1 | transcriptional regulator | - |
| HWI26_RS03650 (HWI26_03610) | - | 715240..716412 (-) | 1173 | WP_000195429.1 | IS256-like element IS256 family transposase | - |
| HWI26_RS03655 (HWI26_03615) | - | 716654..717004 (+) | 351 | WP_002504776.1 | HNH endonuclease | - |
| HWI26_RS03660 (HWI26_03620) | - | 717147..717617 (+) | 471 | WP_002484733.1 | phage terminase small subunit P27 family | - |
| HWI26_RS03665 (HWI26_03625) | - | 717610..719361 (+) | 1752 | WP_002484749.1 | terminase large subunit | - |
| HWI26_RS03670 (HWI26_03630) | - | 719373..719567 (+) | 195 | WP_002500102.1 | hypothetical protein | - |
| HWI26_RS03675 (HWI26_03635) | - | 719570..720802 (+) | 1233 | WP_002504774.1 | phage portal protein | - |
| HWI26_RS03680 (HWI26_03640) | - | 720792..721349 (+) | 558 | WP_002504773.1 | HK97 family phage prohead protease | - |
| HWI26_RS03685 (HWI26_03645) | - | 721389..722738 (+) | 1350 | WP_002504772.1 | phage major capsid protein | - |
| HWI26_RS03690 (HWI26_03650) | - | 722757..723098 (+) | 342 | WP_002484745.1 | head-tail connector protein | - |
| HWI26_RS03695 (HWI26_03655) | - | 723088..723417 (+) | 330 | WP_002484730.1 | hypothetical protein | - |
| HWI26_RS03700 (HWI26_03660) | - | 723531..723818 (+) | 288 | WP_002484720.1 | hypothetical protein | - |
| HWI26_RS03705 (HWI26_03665) | - | 723821..724225 (+) | 405 | WP_002484722.1 | hypothetical protein | - |
| HWI26_RS03710 (HWI26_03670) | - | 724238..724867 (+) | 630 | WP_002484765.1 | major tail protein | - |
| HWI26_RS03715 (HWI26_03675) | - | 724886..725071 (+) | 186 | WP_002484762.1 | hypothetical protein | - |
| HWI26_RS03720 (HWI26_03680) | gpG | 725135..725497 (+) | 363 | WP_002484709.1 | phage tail assembly chaperone G | - |
| HWI26_RS03725 (HWI26_03685) | gpGT | 725542..725682 (+) | 141 | WP_002484764.1 | phage tail assembly chaperone GT | - |
| HWI26_RS03730 (HWI26_03690) | - | 725711..730267 (+) | 4557 | Protein_721 | peptidoglycan DD-metalloendopeptidase family protein | - |
| HWI26_RS03735 (HWI26_03695) | - | 730269..731102 (+) | 834 | WP_002504770.1 | phage tail domain-containing protein | - |
| HWI26_RS03740 (HWI26_03700) | - | 731112..732671 (+) | 1560 | WP_002504769.1 | prophage endopeptidase tail family protein | - |
| HWI26_RS03745 (HWI26_03705) | - | 732664..732837 (+) | 174 | WP_002456411.1 | hypothetical protein | - |
| HWI26_RS03750 (HWI26_03710) | - | 732853..734715 (+) | 1863 | WP_002504768.1 | M14 family metallopeptidase | - |
| HWI26_RS03755 (HWI26_03715) | - | 734715..735929 (+) | 1215 | WP_002504767.1 | BppU family phage baseplate upper protein | - |
| HWI26_RS03760 (HWI26_03720) | - | 735934..736557 (+) | 624 | WP_002504766.1 | poly-gamma-glutamate hydrolase family protein | - |
| HWI26_RS03765 (HWI26_03725) | - | 736554..736979 (+) | 426 | WP_002456415.1 | hypothetical protein | - |
| HWI26_RS03770 (HWI26_03730) | - | 736966..737373 (+) | 408 | WP_002504154.1 | hypothetical protein | - |
| HWI26_RS03775 (HWI26_03735) | - | 737499..737765 (+) | 267 | WP_002504765.1 | phage holin | - |
| HWI26_RS03780 (HWI26_03740) | - | 737765..739147 (+) | 1383 | WP_002504764.1 | N-acetylmuramoyl-L-alanine amidase | - |
| HWI26_RS03785 (HWI26_03745) | - | 739225..740151 (+) | 927 | WP_002504133.1 | hypothetical protein | - |
| HWI26_RS03790 (HWI26_03750) | - | 740344..740871 (+) | 528 | WP_002504240.1 | Panacea domain-containing protein | - |
| HWI26_RS03795 (HWI26_03755) | - | 740861..741259 (+) | 399 | WP_002504241.1 | hypothetical protein | - |
| HWI26_RS03800 | mobV | 742385..742924 (+) | 540 | Protein_735 | MobV family relaxase | - |
| HWI26_RS03805 (HWI26_03770) | - | 743126..743362 (+) | 237 | WP_001829451.1 | hypothetical protein | - |
| HWI26_RS03810 (HWI26_03775) | - | 743575..743916 (+) | 342 | WP_002456621.1 | fatty acid desaturase | - |
Sequence
Protein
Download Length: 191 a.a. Molecular weight: 22782.87 Da Isoelectric Point: 9.2887
>NTDB_id=503335 HWI26_RS03420 WP_001829272.1 696373..696948(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG353]
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
MTHLPETIYVIRKGDMVIRPKYDEYQQTNGTEIIRFDQTRKESPFKVQRIIERSCKFYGNNYISKKAETNRITGISSKPP
ILLTPLFPTYFFPTHSDRQEENIWINMHYIENVKELKNRKSKIIFANGDSLTLNVSFHSLWHQYTNAIIYYYMVDKQSRM
KSNNPEQPIDYNQSSLNIFEALSRYSLFEEN
Nucleotide
Download Length: 576 bp
>NTDB_id=503335 HWI26_RS03420 WP_001829272.1 696373..696948(+) (comK/comK1) [Staphylococcus epidermidis strain UMCG353]
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
ATGACACATTTACCCGAAACGATTTATGTTATACGAAAAGGTGATATGGTAATACGACCTAAATATGATGAATATCAGCA
AACAAATGGTACTGAAATTATCAGATTTGATCAAACTCGCAAAGAAAGTCCATTTAAAGTACAGAGAATTATCGAAAGAT
CATGTAAATTTTATGGTAATAATTATATTAGTAAAAAAGCAGAAACGAATCGTATTACTGGAATCTCTAGTAAACCACCT
ATTTTACTTACGCCTCTTTTTCCTACTTACTTTTTTCCAACTCACTCAGACCGTCAAGAAGAAAATATATGGATTAATAT
GCATTATATTGAAAATGTTAAAGAACTTAAAAATCGTAAGAGTAAAATAATTTTTGCGAATGGTGATTCGTTAACGCTCA
ATGTATCATTTCATAGCTTGTGGCATCAATATACGAATGCAATCATCTATTATTACATGGTAGATAAGCAATCACGAATG
AAATCTAACAACCCTGAACAACCCATTGACTATAATCAGTCTTCTCTAAATATTTTCGAGGCGCTCTCACGCTACTCCCT
TTTTGAAGAAAATTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comK/comK1 | Staphylococcus aureus MW2 |
76.757 |
96.859 |
0.743 |
| comK/comK1 | Staphylococcus aureus N315 |
76.757 |
96.859 |
0.743 |